New iron oxide/silver nanoparticle-based nanocomposites with targeted antibacterial and antifungal properties

The researchers of RCPTM have recently reported a new synthetic route towards magnetic nanocomposites made up of iron oxide and silver nanoparticles where polyacrylate acts as a biocompatible linker. The synthetic procedure and properties of these silver/iron oxide nanocomposites have been recently published in Biomaterials, being a leading journal in the biomaterials research (R. Prucek, J. Tucek, M. Kilianova, A. Panacek, L. Kvitek, J. Filip, M. Kolar, K. Tomankova, and R. Zboril, The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles, Biomaterials 2011, 32, 4704, see link Furthermore, experimental data show that at the observed minimum inhibition concentrations, the synthesized iron oxide/silver nanocomposites do not exhibit acute cytotoxicity against mice embryonal fibroblasts. Thus, the developed material has a high application potential as magnetically controllable antimicrobial agent, which can be readily directed to the specific site, where the disinfection treatment is required and, moreover, it can be separated after an antimicrobial action by the external magnetic field. This research work on biocompatible iron oxide-based nanocomposites follows our previous attempts on synthesis of magnetically controllable silver nanocomposite with multifunctional phosphotriazine matrix (Adv. Funct. Mater. 2010, 20, 2347, see link, and other papers dealing with application of functionalized magnetic nanoparticles in biomedicine (Biomaterials 2009, 30, 2855, see link