RNDr. Jan Hošek, Ph.D.

Contact:

Email: jan.hosek@upol.cz
Address: 17. listopadu 12, Olomouc
Phone: (+420) 54 156 2839

Education and Qualification

2001 – 2006 Molecular biology and genetics, Phaculty of Science, Masaryk University Brno (Mgr.)
2008 Molecular biology and genetics, Phaculty of Science, Masaryk University Brno (RNDr.)
2006 – 2011 General and Molecular genetics, Phaculty of Science, Masaryk University Brno (Ph.D.)
2006 – 2011 Assistant, Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno
2011 – 2014 Research assistant, Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno
since 2011 Junior Researcher, Regional Centre of Advanced Technologies and Materials, Olomouc
since 2014 Research assistant, Department of Molecular Biology and Pharmaceutical Biotechnology, University of Veterinary and Pharmaceutical Sciences Brno

Research activities

  • Molecular biology and genetics
  • Biology activity (anti-inflammatory, cytostatic, cytotoxic) of natural, semi-synthetic and synthetic compounds

Publication activity

  • Number of publications (WoS): 29
  • Number of citations (WoS): 181 (133 without self-citation)
  • H-index: 9
  • Textbooks: 1

Internships

  • VII – IX/2007 – Summer internship in Protein Phosphorylation Unit at the University of Dundee, Scotland
  • XI/2011 – Research internship at the Department of Biology, American University of Beirut, Lebanon
  • V – IX/2012 – Research internship at the Department of Pharmaceutical and Pharmacologial Sciences, Università degli studi di Padova, Italy
  • XI/2014 – Visiting professor at the Pharmaceutical Faculty of the Kazakh National Medical ‎University (2 weeks)

Other activities

  • Grant: FRVŠ (15/2008/F3/b) -Establish of subject “Special practicals from farmacogenomics”
    • € 5 500 (139 000 CZK)/ 1 year (I/2008 – XII/2008)
    • co-worker
  • Reviewer: Journal of Natural Products, African Journal of Biotechnology, Journal of Medicinal Plants Research, Pharmaceutical Biology
  • From 2014: Editorial board member of Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Selected publications

Z. Trávníček, P. Štarha, J. Vančo, T. Šilha, J. Hošek, P. Suchý Jr., G. Pražanová, “Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives,” JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, iss. 10, pp. 4568-4579, 2012.

 Z. Trávníček, J. Vančo, J. Hošek, R. Buchtík, Z. Dvořák, „Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells,“ CHEMISTRY CENTRAL JOURNAL, vol. 6, pp. 160. 2012.

J. Hošek, R. Novotná, P. Babula, J. Vančo, Z. Trávníček, „Zn(II)-Chlorido Complexes of Phytohormone Kinetin and Its Derivatives Modulate Expression of Inflammatory Mediators in THP-1 Cells,“ PLoS ONE. vol. 8, pp. e65214. 2013.

J. Hošek, J. Vančo, P. Štarha, L. Paráková, Z. Trávníček, „Effect of 2-Chloro-Substitution of Adenine Moiety in Mixed-Ligand Gold(I) Triphenylphosphine Complexes on Anti-Inflammatory Activity: The Discrepancy between the In Vivo and In Vitro Models,“ PLoS One. vol. 8, pp. e82441. 2013

R. Křikavová, J. Hošek, P. Suchý Jr, J. Vančo, Z. Trávníček, Diverse in vitro and in vivo anti-inflammatory effects of trichlorido-gold (III) complexes with N6-benzyladenine derivatives. J. Inorg. Biochem. 134: 92-99. 2014.

P. Štarha, J. Hošek, J. Vančo, Z. Dvořák, P. Suchý Jr., I. Popa, G. Pražanová, Z. Trávníček, Pharmacological and Molecular Effects of Platinum(II) Complexes Involving 7-Azaindole Derivatives. PLoS One. 9: e90341. 2014

J. Vančo, J. Gáliková, J. Hošek, Z. Dvořák, L. Paráková, Z. Trávníček, Gold(I) Complexes of 9-Deazahypoxanthine as Selective Antitumor and Anti-Inflammatory Agents. PLoS One. 9: e109901. 2014.

J. Gáliková, J. Hošek, Z. Trávníček, Synthesis, X-ray crystal structure and biological evaluation of zinc(II)-dichlorido complexes with 9-deazahypoxathine derivatives. Inorg. Chim. Acta. 434: 67-73. 2015.