Ján Vančo

2011

• Z. Travnicek, M. Matikova-Malarova, R. Novotna, J. Vanco, K. Stepankova, and P. Suchy, “In vitro and in vivo biological activity screening of Ru(III) complexes
  involving 6-benzylaminopurine derivatives with higher pro-apoptotic
  activity than NAMI-A,” JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 105, iss. 7, pp. 937-948, 2011.
  [Bibtex]

  @article ISI:000291518700002,
  Author = Travnicek, Zdenek and Matikova-Malarova, Miroslava and Novotna, Radka
     and Vanco, Jan and Stepankova, Kamila and Suchy, Pavel,
  Title = In vitro and in vivo biological activity screening of Ru(III) complexes
     involving 6-benzylaminopurine derivatives with higher pro-apoptotic
     activity than NAMI-A,
  Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
  Year = 2011,
  Volume = 105,
  Number = 7,
  Pages = 937-948,
  Month = JUL,
  Abstract = A series of novel octahedral ruthenium(III) complexes involving
     6-benzylaminopurine (L) derivatives as N-donor ligands has been prepared
     by the reaction of [(DMSO)(2)H][trans-RuCl(4)(DMSO)(2)] with the
     corresponding L derivative. The complexes 1-12 have the general
     compositions trans-[RuCl(4)(DMSO)(n-Cl-LH)] center dot xSol (1-3),
     trans-[RuCl(4) (DMSO)(n-Br-LH)] center dot xSol (4-6),
     trans-[RuCl(4)(DMSO)(n-OMe-LH) center dot-xSol (7-9) and
     trans-[RuCl(4)(DMSO)(n-OH-LH)] center dot xSol (10-12); n = 2, 3, and
     4, x = 0-1.5; and Sol = H(2)O, DMSO, EtOH and/or (Me)(2)CO. The
     complexes have been thoroughly characterized by elemental analysis,
     UV-visible, FTIR, Raman, and EPR spectroscopy, ES + (positive ionization
     electrospray) mass spectrometry, thermal analysis, cyclic voltammetry,
     magnetic and conductivity measurements. The X-ray molecular structure of
     trans-[RuCl(4)(DMSO)(3-Br-LH)] center dot (Me)(2)CO (5) revealed the
     distorted octahedral coordination in the vicinity of the central atom,
     and also confirmed that the 3-Br-L ligand is present as the
     N3-protonated N7-H tautomer and is coordinated to Ru(III) through the N9
     atom of the purine moiety. The tested complexes have been found to be in
     vitro non-cytotoxic against 1(562, G361, HOS and MCF7 human cancer cell
     lines with IC(50)> 100 mu M in contrast to the moderate results
     regarding the antiradical activity with IC(50)approximate to 10(-3) M.
     On the contrary, in vivo antitumor activity screening showed that the
     prepared Ru(III) complexes possess higher pro-apoptotic activity than
     NAMI-A. The reduction of Ru(III) to Ru(II) and Ru(II)-species formation
     in tumor tissues was confirmed by means of a simple method of detection
     and visualization of intracellular Rupp by fluorescence microscopy. The
     originality of this method is based on the preparation of a
     Ru(II)-bipyridine complex in situ. (C) 2011 Elsevier Inc. All rights
     reserved.,
  DOI = 10.1016/j.jinorgbio.2011.04.002,
  ISSN = 0162-0134,
  Unique-ID = ISI:000291518700002,
  

• R. Buchtik, Z. Travnicek, J. Vanco, R. Herchel, and Z. Dvorak, “Synthesis, characterization, DNA interaction and cleavage, and in vitro
  cytotoxicity of copper(II) mixed-ligand complexes with
  2-phenyl-3-hydroxy-4(1H)-quinolinone,” DALTON TRANSACTIONS, vol. 40, iss. 37, pp. 9404-9412, 2011.
  [Bibtex]

  @article ISI:000294666700010,
  Author = Buchtik, Roman and Travnicek, Zdenek and Vanco, Jan and Herchel, Radovan
     and Dvorak, Zdenek,
  Title = Synthesis, characterization, DNA interaction and cleavage, and in vitro
     cytotoxicity of copper(II) mixed-ligand complexes with
     2-phenyl-3-hydroxy-4(1H)-quinolinone,
  Journal = DALTON TRANSACTIONS,
  Year = 2011,
  Volume = 40,
  Number = 37,
  Pages = 9404-9412,
  Abstract = A series of mixed-ligand complexes [Cu(qui)(L)]NO(3)center dot xH(2)O
     (1-6), where Hqui = 2-phenyl-3-hydroxy-4(1H)-quinolinone, L =
     2,2'-bipyridine (bpy) (1), 1,10-phenanthroline (phen) (2),
     bis(2-pyridyl)amine (ambpy) (3), 5-methyl-1,10-phenanthroline (mphen)
     (4), 5-nitro-1,10-phenanthroline (nphen) (5) and bathophenanthroline
     (bphen) (6), have been synthesized and fully characterized. The X-ray
     structures of [Cu(qui)(phen)]NO(3)center dot H(2)O (2) and
     [Cu(qui)(ambpy)]NO(3) (3a) show a slightly distorted square-planar
     geometry in the vicinity of the central copper(II) atom. An in vitro
     cytotoxicity study of the complexes found significant activity against
     human osteosarcoma (HOS) and human breast adenocarcinoma (MCF7) cell
     lines, with the best results for complex 6, where IC(50) equals to 2.1
     +/- 0.2 mu M, and 2.2 +/- 0.4 mu M, respectively. The strong
     interactions of the complexes with calf thymus DNA (CT-DNA) and high
     ability to cleave pUC19 DNA plasmid were found. A correlation has been
     found between the in vitro cytotoxicity and DNA cleavage studies of the
     complexes.,
  DOI = 10.1039/c1dt10674k,
  ISSN = 1477-9226,
  Unique-ID = ISI:000294666700010,
  

2010

• J. Vanco, Z. Travnicek, J. Marek, and R. Herchel, “Synthesis, spectral (UV-Vis, IR, ESI-MS), magnetic and structural
  characterizations, and the antimicrobial effect of potassium
  isothiocyanato-(N-salicylidene-amino-acidato)cuprates,” INORGANICA CHIMICA ACTA, vol. 363, iss. 14, pp. 3887-3896, 2010.
  [Bibtex]

  @article ISI:000283051600035,
  Author = Vanco, Jan and Travnicek, Zdenek and Marek, Jaromir and Herchel, Radovan,
  Title = Synthesis, spectral (UV-Vis, IR, ESI-MS), magnetic and structural
     characterizations, and the antimicrobial effect of potassium
     isothiocyanato-(N-salicylidene-amino-acidato)cuprates,
  Journal = INORGANICA CHIMICA ACTA,
  Year = 2010,
  Volume = 363,
  Number = 14,
  Pages = 3887-3896,
  Month = NOV 25,
  Abstract = A series of potassium isothiocyanato-(N-salicylidene-amino acidato)
     cuprates with the general formulas of
     K(2)[Cu(2)(sal-aa)(2)(mu-NCS)(2)]center dot nH(2)O, where n = 0 or 4
     and (sal-aa) stands for the dianion of N-salicylideneamino acid derived
     from glycine (I), DL-alpha-alanine (II), DL-valine (III),
     DL-phenylalanine (IV), and \K[Cu(sal-beta-ala)( mu-NCS)]\(n) for
     beta-alanine (V), respectively, was synthesized and fully characterized
     by elemental analysis, UV-Vis and IR spectroscopy, ESI-MS spectrometry,
     magnetic measurements, and X-ray structural analysis (II and IV). It has
     been found that the copper(II) atom adopts a distorted square-pyramidal
     surrounding in the dimeric complexes I-IV, while the geometry in the
     polymeric complex V can be described as distorted square-bipyramidal.
     The analysis of magnetic properties revealed weak antiferromagnetic
     exchanges in the dinuclear species I-IV and an alternating
     ferro/antiferromagnetic exchange in the case of 1D-polymeric compound V.
     Moreover, the complexes were tested for their antibacterial activity
     against the G+ bacteria Staphylococcus aureus, G- bacteria Escherichia
     coli, filamentous fungi Microsporum gypseum, and yeast Candida albicans.
     The best results were achieved with G+ bacteria S. aureus with MIC
     values in the range of 0.22-0.57 mmol L (1). It may be concluded that
     both the antimicrobial and antifungal activity decreased within the
     tested group of cuprates derived from alpha-amino acids with the
     increasing lipophility of the complexes, i.e. I -> IV. (C) 2010 Elsevier
     B.V. All rights reserved.,
  DOI = 10.1016/j.ica.2010.07.041,
  ISSN = 0020-1693,
  Unique-ID = ISI:000283051600035,
  

• A. Klanicova, Z. Travnicek, J. Vanco, I. Popa, and Z. Sindelar, “Dinuclear copper(II) perchlorate complexes with 6-(benzylamino)purine
  derivatives: Synthesis, X-ray structure, magnetism and antiradical
  activity,” POLYHEDRON, vol. 29, iss. 13, pp. 2582-2589, 2010.
  [Bibtex]

  @article ISI:000282389900003,
  Author = Klanicova, Alena and Travnicek, Zdenek and Vanco, Jan and Popa, Igor and
     Sindelar, Zdenek,
  Title = Dinuclear copper(II) perchlorate complexes with 6-(benzylamino)purine
     derivatives: Synthesis, X-ray structure, magnetism and antiradical
     activity,
  Journal = POLYHEDRON,
  Year = 2010,
  Volume = 29,
  Number = 13,
  Pages = 2582-2589,
  Month = SEP 3,
  Abstract = The reactions of Cu(ClO4)(2)center dot 6H(2)O with 6-(benzylamino)purine
     derivatives in a stoichiometric 1:2 metal-to-ligand ratio led to the
     formation of penta-coordinated dinuclear complexes of the formula
     [Cu(2)(mu-L(1-8))(4)(ClO(4))2](ClO(4))(2).nsolv, where L(1) =
     6-(2-fluorobenzylamino)purine (complex 1), L(2) =
     6-(3-fluorobenzylamino)purine (2), L(3)= 6-(4-fluorobenzylamino)purine
     (3), L(4)= 6-(2-chlorobenzylamino)purine (4), L(5) =
     6-(3-chlorobenzylamino)purine (5), L(6)=6-(4-chlorobenzylamino)purine
     (6), L(7)= 6-(3-methoxybenzylamino)purine (7) and L(8)=
     6-(4-methoxybenzylamino)purine (8); n = 0-4 and solv = H(2)O, EtOH or
     MeOH. All the complexes have been fully characterized by elemental
     analysis, FTIR, UV-Vis and EPR spectroscopy, and by magnetic and
     conductivity measurements. Variable temperature (80-300 K) magnetic
     susceptibility data of 1-8 showed the presence of a strong
     antiferromagnetic exchange interaction between two Cu(II) (S= 1/2) atoms
     with J ranging from -150.0(1) to -160.3(2)cm(-1). The compound 6 center
     dot 4EtOH center dot H(2)O was structurally characterized by single
     crystal X-ray analysis. The Cu center dot center dot center dot Cu
     separation has been found to be 2.9092(8) angstrom. The antiradical
     activity of the prepared compounds was tested by in vitro SOD-mimic
     assay with IC(50) in the range 8.67-41.45 mu M. The results of an in
     vivo antidiabetic activity assay were inconclusive and the glycaemia in
     pre-treated animals did not differ significantly from the positive
     control. (C) 2010 Elsevier Ltd. All rights reserved.,
  DOI = 10.1016/j.poly.2010.06.007,
  ISSN = 0277-5387,
  Unique-ID = ISI:000282389900003,
  

• P. Babula, J. Vanco, V. Kohoutkova, I. Dankova, L. Ohnoutkova, L. Havel, and R. Kizek, “Phytotoxicity of New Complex of Lawsone with Cu(II) Ions,” IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, vol. 46, iss. S, pp. S148, 2010.
  [Bibtex]

  @article ISI:000285367500330,
  Author = Babula, Petr and Vanco, Jan and Kohoutkova, Veronika and Dankova, Ivana
     and Ohnoutkova, Ludmila and Havel, Ladislav and Kizek, Rene,
  Title = Phytotoxicity of New Complex of Lawsone with Cu(II) Ions,
  Journal = IN VITRO CELLULAR \& DEVELOPMENTAL BIOLOGY-ANIMAL,
  Year = 2010,
  Volume = 46,
  Number = S,
  Pages = S148,
  Month = SPR,
  ISSN = 1071-2690,
  Unique-ID = ISI:000285367500330,
  

2009

• P. Starha, Z. Travnicek, R. Herchel, I. Popa, P. Suchy, and J. Vanco, “Dinuclear copper(II) complexes containing 6-(benzylamino)purines as
  bridging ligands: Synthesis, characterization, and in vitro and in vivo
  antioxidant activities,” JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 103, iss. 3, pp. 432-440, 2009.
  [Bibtex]

  @article ISI:000263693900016,
  Author = Starha, Pavel and Travnicek, Zdenek and Herchel, Radovan and Popa, Igor
     and Suchy, Pavel and Vanco, Jan,
  Title = Dinuclear copper(II) complexes containing 6-(benzylamino)purines as
     bridging ligands: Synthesis, characterization, and in vitro and in vivo
     antioxidant activities,
  Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
  Year = 2009,
  Volume = 103,
  Number = 3,
  Pages = 432-440,
  Month = MAR,
  Abstract = A series of dinuclear copper(II) complexes involving
     6-(benzylamino)purine derivatives, (HL(n)), as bridging ligands were
     synthesized, characterized and tested for both their in vitro and in
     vivo antioxidant activities. Based on results of elemental analyses,
     temperature dependence of magnetic susceptibility measurements, UV-vis,
     FTIR, EPR, NMR and MALDI-TOF mass spectroscopy, conductivity
     measurements and thermal analyses, the complexes with general
     compositions Of [Cu(2)(mu-HL(n))(4)Cl(2)]Cl(2)center dot 2H(2)O (1-4)
     and [Cu(2)(mu-HL(n))(2)(mu-Cl)(2)Cl(2)] (5-7) were prepared [where n
     = 1-4; HL(1) = 6-[(2-methoxybenzyl)amino]purine, HL(2) =
     6-[(4-methoxybenzyl)amino]purine, HL(3) =
     6-[(2,3-dimethoxybenzyl)amino]purine and HL(4) =
     6[(3,4-dimethoxybenzyl)amino]purine). In the case of complexes 2, 3, 5
     and 7, the antioxidant activities were studied by both in vitro
     [superoxide dismutase-mimic (SOD-mimic) activity) and in vivo
     (cytoprotective effect against the alloxan-induced diabetes
     (antidiabetic activity)) methods. The obtained IC(50) value of the
     SOD-mimic activity for the complex 5 (IC(50) = 0.253 mu M) was shown to
     be even better than that of the native bovine Cu,Zn-SOD enzyme (IC(50) =
     0.480 mu M), used as a standard. As for the antidiabetic activity, the
     pretreatment of mice with complexes 3 and 7 led to the complete
     elimination of cytotoxic attack of alloxan and its free radical
     metabolites, used as a diabetogenic agent. The cytoprotective effect of
     these compounds was proved by the preservation of the initial blood
     glucose levels of the pretreated animals, as against the untreated
     control group. (C) 2008 Elsevier Inc. All rights reserved.,
  DOI = 10.1016/j.jinorgbio.2008.12.009,
  ISSN = 0162-0134,
  Unique-ID = ISI:000263693900016,
  

• R. Herchel, Z. Sindelar, Z. Travnicek, R. Zboril, and J. Vanco, "Novel 1D chain Fe(III)-salen-like complexes involving anionic
  heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic,
  (57)Fe Mossbauer, and biological activity studies," DALTON TRANSACTIONS, iss. 44, pp. 9870-9880, 2009.
  [Bibtex]

  @article ISI:000271432600028,
  Author = Herchel, Radovan and Sindelar, Zdenek and Travnicek, Zdenek and Zboril,
     Radek and Vanco, Jan,
  Title = Novel 1D chain Fe(III)-salen-like complexes involving anionic
     heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic,
     (57)Fe Mossbauer, and biological activity studies,
  Journal = DALTON TRANSACTIONS,
  Year = 2009,
  Number = 44,
  Pages = 9870-9880,
  Abstract = The iron(III) salen-type complexes [Fe(salen)(L)](n) (1-6) involving
     heterocyclic N-donor ligands HL \HL = 1H-imidazole (Himz),
     1H-tetrazol-5-amine (Hatz), 5-methyl-1H-tetrazole (Hmtz),
     1H-benzimidazole (Hbimz), 1H-1,2,4-triazole (Htriz) and 1H-benzotriazole
     (Hbtriz)\ have been prepared and characterised by elemental analysis,
     FT IR, CI mass and (57)Fe Mossbauer spectroscopies, and variable
     temperature magnetic measurements. Single crystal X-ray analysis of
     [Fe(salen)(btriz)](n) (6) revealed a 1D chain-polymeric structure of
     the complex with the btriz anion as a bridging ligand. Magnetic data for
     all complexes were fitted using Fisher's model (for S = 5/2) and also
     using a heptanuclear closed ring model showing a weak antiferromagnetic
     interaction (J approximate to -1 to -2 cm(-1)), and moreover,
     molecule-based magnet properties have been observed in the case of
     [Fe(salen)(atz)](n) (2). The exponential correlation between the
     magnetic properties (the isotropic exchange parameter J) and the
     basicity of the free ligands (K(b)) has been found. The
     antiferromagnetic ordering as well as a moderate structural
     dissimilarity in the vicinity of iron atoms has been proved by the
     (57)Fe Mossbauer low-temperature (2 K) in-field (7 T) experiments in the
     case of (2), in which two sextets with the line intensities
     (3/4/1/3/4/1) have been observed. The compounds have been tested for
     their SOD-like activity, DNA cleavage activity, and in vitro
     cytotoxicity against two human cancer cell lines: chronic myelogenous
     erythroleukemia (K562) and breast adenocarcinoma (MCF7). The best result
     regarding the cytotoxicity has been achieved for the complex of
     [Fe(salen)(atz)](n) (2), where IC(50) = 6.4 mu M against K562.,
  DOI = 10.1039/b912676g,
  ISSN = 1477-9226,
  Unique-ID = ISI:000271432600028,
  

2008

• J. Vanco, J. Marek, Z. Travnicek, E. Racanska, J. Muselik, and O. Svajlenova, "Synthesis, structural characterization, antiradical and antidiabetic
  activities of copper(II) and zinc(II) Schiff base complexes derived from
  salicylaldehyde and beta-alanine," JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 102, iss. 4, pp. 595-605, 2008.
  [Bibtex]

  @article ISI:000255131500001,
  Author = Vanco, Jan and Marek, Jaromir and Travnicek, Zdenek and Racanska, Eva
     and Muselik, Jan and Svajlenova, Ol'ga,
  Title = Synthesis, structural characterization, antiradical and antidiabetic
     activities of copper(II) and zinc(II) Schiff base complexes derived from
     salicylaldehyde and beta-alanine,
  Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
  Year = 2008,
  Volume = 102,
  Number = 4,
  Pages = 595-605,
  Month = APR,
  Abstract = A series of copper(II) and zinc(II) complexes involving a tridentate
     0,N,O'-donor Schiff base derived from salicylaldehyde and P-alanine I
     i.e. N-salicylidene-beta-alanine(2-), (L)), having the composition
     [Cu-2(L)(2)(H2O)].H2O (1), [Cu(L)(H2O)](n) (2), and
     [Zn(L)(H2O)](n) (3), have been prepared and characterized by elemental
     analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal
     analyses. Complexes I and 2 have been investigated by single crystal
     X-ray analysis and also by temperature dependent magnetic susceptibility
     measurements (294-80 K). All prepared complexes have been evaluated by
     the antiperoxynitrite activity assay and alloxan-induced diabetes model.
     The significant antioxidant and antidiabetic activities have been found
     in the case of both copper(II) complexes 1 and 2. In spite of first two
     complexes, the zinc(II) complex 3, as well as the potassium salt of the
     ligand (KHL) showed only insignificant protective effect against the
     tyrosine nitration in vitro. (c) 2007 Elsevier Inc. All rights reserved.,
  DOI = 10.1016/j.jinorgbio.2007.10.003,
  ISSN = 0162-0134,
  Unique-ID = ISI:000255131500001,
  

• Z. Travnicek, J. Marek, J. Vanco, and O. Svajlenova, "Aqua(4-methylquinoline-kappa N)[N-(2-oxidobenzylidene)glycinato-kappa
  O-3,N,O `]copper(II) hemihydrate," ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, vol. 64, iss. Part 2, pp. M282-U199, 2008.
  [Bibtex]

  @article ISI:000253779700023,
  Author = Travnicek, Zdenek and Marek, Jaromir and Vanco, Jan and Svajlenova, Olga,
  Title = Aqua(4-methylquinoline-kappa N)[N-(2-oxidobenzylidene)glycinato-kappa
     O-3,N,O `]copper(II) hemihydrate,
  Journal = ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE,
  Year = 2008,
  Volume = 64,
  Number = Part 2,
  Pages = M282-U199,
  Month = FEB,
  DOI = 10.1107/S1600536807067852,
  ISSN = 1600-5368,
  Unique-ID = ISI:000253779700023,
  

2007

• F. Sersen, D. Loos, J. Csollei, I. Popa, J. Vanco, and F. Gregan, "Antioxidative activity of potential antihypertensives with dual effect," CHEMICKE LISTY, vol. 101, iss. 1, pp. 60-64, 2007.
  [Bibtex]

  @article ISI:000243899600009,
  Author = Sersen, Frantisek and Loos, Dusan and Csollei, Jozef and Popa, Igor and
     Vanco, Jan and Gregan, Fridrich,
  Title = Antioxidative activity of potential antihypertensives with dual effect,
  Journal = CHEMICKE LISTY,
  Year = 2007,
  Volume = 101,
  Number = 1,
  Pages = 60-64,
  Abstract = The antioxidative properties of four
     1-(2-benzofuran2-yl-2-hydroxyethyl)-4-phenylpiperazines were studied by
     indirect spectrophotometric and direct ESR spin-trap methods. The
     radical scavenging activity of the tested compounds was determined. The
     compounds exhibit interesting structure-specific redox properties.
     Scavenging of DPPH radicals gave very poor results. The studied
     compounds did not affect the elimination of superoxide anion radicals;
     however, they caused stimulation of O-2(-.) radical production. The
     hydroxyl radicals, however, were scavenged only by 2-fluorophenyl
     derivatives, whereas the 4-fluorophenyl derivatives exhibited a slightly
     prooxidative effect. The capture of HO. radicals by 2-fluorophenyl
     derivatives was, according to the results of NMR analyses, attributed to
     the interaction with non-protonated piperazine nitrogen atom, which is
     stabilized by the hydrogen bond between the hydroxy group and fluorine
     atom.,
  ISSN = 0009-2770,
  Unique-ID = ISI:000243899600009,