Regional Centre of Advanced Technologies and Materials

Kontakt:

Email: jan.vanco@upol.cz
Adresa: 17. listopadu 12, Olomouc
Telefon: (+420) 58 563 4351
Fax: (+420) 58 563 4357

Syntéza, strukturní a spektrální analýza nových bioaktivních komplexů Cu(II), Zn(II), Fe(III), Co(II/III), Ni(II), Mn(II) s ligandy typu Schiffových basí.
Studium chemické reaktivity a biologických aktivit se zaměřením na antiradikálovou, antimikrobní, antidiabetickou a cytotoxickou aktivitu.
Analytické hodnocení metabolitů oxidačního poškození biomolekul, vývoj metod stanovení s použitím HPLC-DAD/FLD, LC/MS.
Analytické hodnocení obsahových látek rostlinných drog a identifikace sekundárních metabolitů pomocí HPLC-DAD/FLD, LC/MS a ESI-MS spektroskopie.
Vývoj a validace metod analýzy léčiv v biologických vzorcích.

1996 – 2001	Farmácia, Univerzita Komenského v Bratislave, Slovenská Republika (Mgr.)
2001	Rigorózna skúška, Farmácia, Univerzita Komenského v Bratislave, Slovenská Republika (PharmDr.)
2001 – 2011	Doktorský studijní program Farmacie, obor Farmaceutická chemie, Ústav chemických léčiv, Farmaceutická fakulta VFU Brno (Ph.D.)
2002 – 2010	Asistent, Ústav chemických léčiv, Farmaceutická fakulta VFU Brno
2005 – 2010	Vědecký pracovník, Katedra anorganické chemie, PřF UP v Olomouci

od 2010	Odborný asistent, Ústav chemických léčiv, Farmaceutická fakulta VFU Brno
od 2010	Junior Researcher, Regionální centrum pokročilých technologií a materiálů PřF UP v Olomouci

Buchtík R., Trávníček Z., Vančo J., Herchel R., Dvořák Z.: Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(ii) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)- quinolinone. Dalton Trans. 40(37), 9404-9412 (2011).
Trávníček Z., Matíková-Maľarová M., Novotná R., Vančo J., Štěpánková K., Suchý P. Jr.: In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A. J. Inorg. Biochem. 105(7), 937-948 (2011).
Vančo J., Trávníček Z., Marek J., Herchel R.: Synthesis, spectral (UV/Vis, IR, ESI-MS), magnetic and structural characterizations, and antimicrobial effect of potassium isothiocyanato-(N-salicylideneamino-acidato)cuprates. Inorg. Chim. Acta 363(14), 3887-3896 (2010).
Herchel R., Šindelář Z., Trávníček Z., Zbořil R., Vančo J.: Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, 57Fe Mössbauer, and biological activity studies. Dalton Trans. (44), 9870-9880 (2009).
Štarha P., Trávníček Z., Herchel R., Popa I., Suchý P. ml., Vančo J.: Dinuclear copper(II) complexes containing 6-(benzylamino)purines as bridging ligands: Synthesis, characterization, and in vitro and in vivo antioxidant activities. J. Inorg. Biochem. 103, 432-440 (2009).

Z. Travnicek, P. Starha, J. Vanco, T. Silha, J. Hosek, P. Suchy Jr., and G. Prazanova, “Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives,” JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, iss. 10, pp. 4568-4579, 2012.

Z. Travnicek, M. Matikova-Malarova, R. Novotna, J. Vanco, K. Stepankova, and P. Suchy, “In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A,” JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 105, iss. 7, pp. 937-948, 2011.
R. Buchtik, Z. Travnicek, J. Vanco, R. Herchel, and Z. Dvorak, “Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone,” DALTON TRANSACTIONS, vol. 40, iss. 37, pp. 9404-9412, 2011.

J. Vanco, Z. Travnicek, J. Marek, and R. Herchel, “Synthesis, spectral (UV-Vis, IR, ESI-MS), magnetic and structural characterizations, and the antimicrobial effect of potassium isothiocyanato-(N-salicylidene-amino-acidato)cuprates,” INORGANICA CHIMICA ACTA, vol. 363, iss. 14, pp. 3887-3896, 2010.
A. Klanicova, Z. Travnicek, J. Vanco, I. Popa, and Z. Sindelar, “Dinuclear copper(II) perchlorate complexes with 6-(benzylamino)purine derivatives: Synthesis, X-ray structure, magnetism and antiradical activity,” POLYHEDRON, vol. 29, iss. 13, pp. 2582-2589, 2010.
P. Babula, J. Vanco, V. Kohoutkova, I. Dankova, L. Ohnoutkova, L. Havel, and R. Kizek, “Phytotoxicity of New Complex of Lawsone with Cu(II) Ions,” IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, vol. 46, iss. S, pp. S148, 2010.

P. Starha, Z. Travnicek, R. Herchel, I. Popa, P. Suchy, and J. Vanco, “Dinuclear copper(II) complexes containing 6-(benzylamino)purines as bridging ligands: Synthesis, characterization, and in vitro and in vivo antioxidant activities,” JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 103, iss. 3, pp. 432-440, 2009.
R. Herchel, Z. Sindelar, Z. Travnicek, R. Zboril, and J. Vanco, “Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, Fe-57 Mossbauer, and biological activity studies,” DALTON TRANSACTIONS, iss. 44, pp. 9870-9880, 2009.

J. Vanco, J. Marek, Z. Travnicek, E. Racanska, J. Muselik, and O. Svajlenova, “Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine,” JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 102, iss. 4, pp. 595-605, 2008.
Z. Travnicek, J. Marek, J. Vanco, and O. Svajlenova, “Aqua(4-methylquinoline-kappa N)[N-(2-oxidobenzylidene)glycinato-kappa O-3,N,O `]copper(II) hemihydrate,” ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, vol. 64, iss. Part 2, pp. M282-U199, 2008.

F. Sersen, D. Loos, J. Csollei, I. Popa, J. Vanco, and F. Gregan, “Antioxidative activity of potential antihypertensives with dual effect,” CHEMICKE LISTY, vol. 101, iss. 1, pp. 60-64, 2007.