Radim Vrzal

Contact:

Email: radim.vrzal@email.cz
Address: Šlechtitelů 27, Olomouc
Phone: (+420) 585 634 904

Qualification

1998-2003 M.S. in Biochemistry, Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, Institute of Chemical Technology in Prague, Czech Republic
Thesis: „Immunochemical detection of endosulfan“
2003-2007 Ph.D. with co-supervision (cotutelle de these) at Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic and Detoxication et Physiopathologie Hepatique, Institute National de la Sante Et de la Recherche Medicale, INSERM U632, CNRS, Montpellier, France (group of Dr.Maurel)
Thesis: „Effects of microtubule-interfering agents on aryl hydrocarbon receptor signalling“
2006-2008 Assistent professor, Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
2008-2011 Assistent professor, Department of Cell Biology and Genetics, Palacky University, Olomouc, Czech Republic
Since 2011 Associate professor, Department of Cell Biology and Genetics, Palacky University, Olomouc, Czech Republic

Research interests

  • Regulation of biotransformation enzymes expression
  • Drug-drug interactions

Publication activity

  • Počet publikací (WoS): 47
  • Počet citací (WoS): 558
  • H-index: 16

Foreign research stays

2005, 2006 Detoxication et Physiopathologie Hepatique, Institute National de la Sante Et de la Recherche Medicale, INSERM U632, CNRS, Montpellier, France (group of Dr.Maurel)
2009 Hungarian Academy of Sciences, Chemical Research Center, Budapest, Hungary – (group of Dr. Katalin Monostory) (3 weeks)
2014 UniversitätsKlinikum Heidelberg, Clinical Pharmacology and Pharmacoepidemiology, Heidelberg, Germany (group of Prof.Johanna Weiss) (1 month)

Further activities

  • Principal investigator of GACR project (305/08/P089) – 2008-2010
  • Co-investigator of GACR project (P303/12/0472) – 2012-2016

Selected publications

Dvorak, Srovnalova, Svecarova, Vrzal:  The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes. Food Funct. 2014, 5(9): 2145-51. (IF2013 = 2,907)

Vrzal et al: Khellin and Visnagin Differentially Modulate AHR Signaling and Downstream CYP1A Activity in Human Liver Cells. PLOS ONE. 2013, 8(9). (IF2013 = 3,73)