Radka Novotná

2011

• Z. Travnicek, M. Matikova-Malarova, R. Novotna, J. Vanco, K. Stepankova, and P. Suchy, “In vitro and in vivo biological activity screening of Ru(III) complexes
  involving 6-benzylaminopurine derivatives with higher pro-apoptotic
  activity than NAMI-A,” JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 105, iss. 7, pp. 937-948, 2011.
  [Bibtex]

  @article ISI:000291518700002,
  Author = Travnicek, Zdenek and Matikova-Malarova, Miroslava and Novotna, Radka
     and Vanco, Jan and Stepankova, Kamila and Suchy, Pavel,
  Title = In vitro and in vivo biological activity screening of Ru(III) complexes
     involving 6-benzylaminopurine derivatives with higher pro-apoptotic
     activity than NAMI-A,
  Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
  Year = 2011,
  Volume = 105,
  Number = 7,
  Pages = 937-948,
  Month = JUL,
  Abstract = A series of novel octahedral ruthenium(III) complexes involving
     6-benzylaminopurine (L) derivatives as N-donor ligands has been prepared
     by the reaction of [(DMSO)(2)H][trans-RuCl(4)(DMSO)(2)] with the
     corresponding L derivative. The complexes 1-12 have the general
     compositions trans-[RuCl(4)(DMSO)(n-Cl-LH)] center dot xSol (1-3),
     trans-[RuCl(4) (DMSO)(n-Br-LH)] center dot xSol (4-6),
     trans-[RuCl(4)(DMSO)(n-OMe-LH) center dot-xSol (7-9) and
     trans-[RuCl(4)(DMSO)(n-OH-LH)] center dot xSol (10-12); n = 2, 3, and
     4, x = 0-1.5; and Sol = H(2)O, DMSO, EtOH and/or (Me)(2)CO. The
     complexes have been thoroughly characterized by elemental analysis,
     UV-visible, FTIR, Raman, and EPR spectroscopy, ES + (positive ionization
     electrospray) mass spectrometry, thermal analysis, cyclic voltammetry,
     magnetic and conductivity measurements. The X-ray molecular structure of
     trans-[RuCl(4)(DMSO)(3-Br-LH)] center dot (Me)(2)CO (5) revealed the
     distorted octahedral coordination in the vicinity of the central atom,
     and also confirmed that the 3-Br-L ligand is present as the
     N3-protonated N7-H tautomer and is coordinated to Ru(III) through the N9
     atom of the purine moiety. The tested complexes have been found to be in
     vitro non-cytotoxic against 1(562, G361, HOS and MCF7 human cancer cell
     lines with IC(50)> 100 mu M in contrast to the moderate results
     regarding the antiradical activity with IC(50)approximate to 10(-3) M.
     On the contrary, in vivo antitumor activity screening showed that the
     prepared Ru(III) complexes possess higher pro-apoptotic activity than
     NAMI-A. The reduction of Ru(III) to Ru(II) and Ru(II)-species formation
     in tumor tissues was confirmed by means of a simple method of detection
     and visualization of intracellular Rupp by fluorescence microscopy. The
     originality of this method is based on the preparation of a
     Ru(II)-bipyridine complex in situ. (C) 2011 Elsevier Inc. All rights
     reserved.,
  DOI = 10.1016/j.jinorgbio.2011.04.002,
  ISSN = 0162-0134,
  Unique-ID = ISI:000291518700002,
  

• R. Novotna, I. Popa, and Z. Travnicek, “Zinc(II) chlorido complexes of protonated kinetin and its derivatives:
  Synthesis, properties and X-ray structure of [Zn(Hkinetin)Cl(3)]center
  dot kinetin,” INORGANICA CHIMICA ACTA, vol. 365, iss. 1, pp. 113-118, 2011.
  [Bibtex]

  @article ISI:000285624200017,
  Author = Novotna, Radka and Popa, Igor and Travnicek, Zdenek,
  Title = Zinc(II) chlorido complexes of protonated kinetin and its derivatives:
     Synthesis, properties and X-ray structure of [Zn(Hkinetin)Cl(3)]center
     dot kinetin,
  Journal = INORGANICA CHIMICA ACTA,
  Year = 2011,
  Volume = 365,
  Number = 1,
  Pages = 113-118,
  Month = JAN 15,
  Abstract = The syntheses and characterization of five novel zinc(II) complexes with
     protonated kinetin (6-furfurylaminopurine) and its derivatives are
     described. Based on the results following from elemental analyses (C, H,
     N), FTIR, Raman, (1)H and (13)C NMR spectroscopy, conductivity
     measurements, thermogravimetric (TG) and differential thermal analyses
     (DTA), and single crystal X-ray analysis, the complexes of the general
     composition [Zn(HL(n))Cl(3)]center dot xL(n) (1-5) have been prepared,
     where L(1) = kinetin (6-furfurylaminopurine), L(2) =
     6-(5-methylfurfurylamino) purine, L(3) = 2-chloro-6-furfurylaminopurine,
     L(4) = 2-chloro-6-(5-methylfurfurylamino) purine and L(5) =
     2-chloro-6-furfurylamino-9-isopropylpurine, and x = 1/2-2. The structure
     of [Zn(HL(1))Cl(3)]center dot L(1) (1) has been determined by single
     crystal X-ray analysis. The Zn(II) atom is tetrahedrally coordinated by
     three chlorido ligands and one N3-protonated organic molecule forming a
     ZnCl(3)N donor set. The organic ligand L(1) is coordinated to the Zn(II)
     centre through the N7 atom of the purine moiety. NMR spectroscopic study
     confirmed the N3 and N7 atom to be the protonation, and coordination
     site, respectively. (C) 2010 Elsevier B.V. All rights reserved.,
  DOI = 10.1016/j.ica.2010.08.040,
  ISSN = 0020-1693,
  Unique-ID = ISI:000285624200017,
  

• Z. Travnicek, R. Novotna, J. Marek, I. Popa, and M. Sipl, “Transformations of the natural cytokinin N6-isopentenyladenine in
  aqueous acidic media: structural aspects,” ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, iss. 16, pp. 5703-5713, 2011.
  [Bibtex]

  @article ISI:000293230300015,
  Author = Travnicek, Zdenek and Novotna, Radka and Marek, Jaromir and Popa, Igor
     and Sipl, Michal,
  Title = Transformations of the natural cytokinin N6-isopentenyladenine in
     aqueous acidic media: structural aspects,
  Journal = ORGANIC \& BIOMOLECULAR CHEMISTRY,
  Year = 2011,
  Volume = 9,
  Number = 16,
  Pages = 5703-5713,
  Abstract = N6-Isopentenyladenine (L1) was subjected to variously acidic media in
     0.1 M, 1 M and 2 M HCl. In dependence on the acidity of the medium, the
     formation of three main acid hydrolysis products, involving the
     N6-isopentenyladeninium (HL1) (1),
     7,8,9,10-tetrahydro-7,7-dimethyl-3H-pyrimido[ 2,1-i]purin-6-ium (HL2)
     (2) or
     5-amino-4-(4,4-dimethyl-3,4,5,6-tetrahydropyrimidin-2-yl)-imidazolium
     (H(2)L3) (3-5) cations, were determined and characterized by
     multinuclear solution-state NMR spectroscopy and in the solid state by
     single crystal X-ray analysis. The coordination abilities of these
     transformation products have been also investigated. The compounds of
     the compositions [Zn(HL1)Cl(3)]center dot H(2)O (1),
     [Zn(3)(HL2)(2)Cl(8)] (2), (H(2)L3)[CuCl(4)] (4) and
     (H(2)L3)[ZnCl(4)] (5) have been prepared in dependence on the acidity
     of the medium used by the reactions of L1 with ZnCl(2)center dot
     1.5H(2)O or CuCl(2)center dot 2H(2)O. Based on the NMR spectroscopic and
     X-ray crystallographic results, the mechanism of transformation of L1 in
     the acidic medium, involving the protonation, cyclization and ring
     fission, has been suggested.,
  DOI = 10.1039/c1ob05649b,
  ISSN = 1477-0520,
  Unique-ID = ISI:000293230300015,
  

2010

• M. Matikova-Malarova, R. Novotna, and Z. Travnicek, “X-ray structures and spectral characterization of simple ruthenium(II)
  nitrosyl complexes involving the [RuCl(4)(NO)(DMS(O)under-bar)](-) or
  [RuCl(4)(NO)(H(2)O)](-) complex anions,” JOURNAL OF MOLECULAR STRUCTURE, vol. 977, iss. 1-3, pp. 203-209, 2010.
  [Bibtex]

  @article ISI:000280498600028,
  Author = Matikova-Malarova, Miroslava and Novotna, Radka and Travnicek, Zdenek,
  Title = X-ray structures and spectral characterization of simple ruthenium(II)
     nitrosyl complexes involving the [RuCl(4)(NO)(DMS(O)under-bar)](-) or
     [RuCl(4)(NO)(H(2)O)](-) complex anions,
  Journal = JOURNAL OF MOLECULAR STRUCTURE,
  Year = 2010,
  Volume = 977,
  Number = 1-3,
  Pages = 203-209,
  Month = AUG 10,
  Abstract = Three simple ruthenium nitrosyl complexes of the compositions
     [Et(4)N][RuCl(4)(NO)(DMS (O) under bar)](-) (1),
     [Bu(4)N][RuCl(4)(NO)(DMS (O) under bar)](-) (2), and
     [Pli(4)PI[RuCl(4)(NO)(H(2)O]center dot DMSO (3); where DMSO =
     dimethyl sulfoxide, Et = ethyl, Bu = butyl and Ph = phenyl, have been
     synthesized in the single crystal form and their molecular and crystal
     structures have been determined. The Ru(II) centre is six-coordinated by
     four chlorido ligands in the equatorial plane and by the N (from NO(+))
     and O (from DMS (O) under bar in 1 and 2, H(2)O in 3) atoms in the axial
     positions forming an RuCI4NO donor set. The complexes have been also
     characterized by infrared and electronic spectroscopies, conductivity
     measurements, and thermogravimetric (TG) and differential thermal (DTA)
     analyses. The spectroscopic investigation is consistent with the
     (Ru(NO))(6) formulation with NO(+) coordinated to the diamagnetic Ru(II)
     centre. The geometries of the complex anions as well as spectroscopic
     properties were calculated at the B3LYP/LANL2DZ/cc-pVTZ level of theory.
     These results were compared with those experimentally determined. (C)
     2010 Elsevier B.V. All rights reserved.,
  DOI = 10.1016/j.molstruc.2010.05.033,
  ISSN = 0022-2860,
  Unique-ID = ISI:000280498600028,
  

• R. Novotna, Z. Travnicek, and I. Popa, “Synthesis and characterization of the first zinc(II) complexes involving
  kinetin and its derivatives: X-ray structures of
  2-chloro-N6-furfuryl-9-isopropyladenine and
  [Zn(kinetin)(2)Cl(2)]center dot CH(3)OH,” INORGANICA CHIMICA ACTA, vol. 363, iss. 10, pp. 2071-2079, 2010.
  [Bibtex]

  @article ISI:000278592200003,
  Author = Novotna, Radka and Travnicek, Zdenek and Popa, Igor,
  Title = Synthesis and characterization of the first zinc(II) complexes involving
     kinetin and its derivatives: X-ray structures of
     2-chloro-N6-furfuryl-9-isopropyladenine and
     [Zn(kinetin)(2)Cl(2)]center dot CH(3)OH,
  Journal = INORGANICA CHIMICA ACTA,
  Year = 2010,
  Volume = 363,
  Number = 10,
  Pages = 2071-2079,
  Month = JUN 20,
  Abstract = A series of the first zinc(II) complexes of the general composition
     [Zn(L(n))(2)Cl(2)]center dot xSolv (1-5) involving kinetin
     [N6-furfuryladenine, L(1), xSolv = CH(3)OH, complex 1] and its
     derivatives, i.e. N6-(5-methylfurfuryl)adenine (L(2), xSolv = 2H(2)O,
     2), 2-chloro-N6-furfuryladenine (L(3), 3),
     2-chloro-N6-(5-methylfurfuryl)adenine (L(4), 4) and
     2-chloro-N6-furfuryl-9-isopropyladenine (L(5), 5), as N-donor ligands
     has been synthesized. The complexes have been fully characterized by
     elemental analyses (C, H, N), FTIR, Raman, (1)H and (13)C NMR
     spectroscopy, conductivity measurements, thermogravimetric (TG) and
     differential thermal (DTA) analyses. Single crystal X-ray analysis
     determined the molecular structures of
     2-chloro-N6-furfuryl-9-isopropyladenine (L(5)) and the complex
     [Zn(L(1))(2)Cl(2)]center dot CH(3)OH. The Zn(II) ion is tetrahedrally
     coordinated by two chlorido ligands and two molecules of the L(1)
     organic compound. The two ligands L(1) are coordinated to the central
     Zn(II) ion via the N7 atoms. This conclusion can also be drawn from
     multinuclear NMR spectroscopic experiments. (C) 2010 Elsevier B.V. All
     rights reserved.,
  DOI = 10.1016/j.ica.2010.02.004,
  ISSN = 0020-1693,
  Unique-ID = ISI:000278592200003,
  

• P. Starha, R. Novotna, and Z. Travnicek, “X-ray structure and properties of a dinuclear palladium(II) complex
  [Pd(2)(mu-L)(4)] with four adenine-based bridges in a paddle
  wheel-like arrangement,” INORGANIC CHEMISTRY COMMUNICATIONS, vol. 13, iss. 6, pp. 800-803, 2010.
  [Bibtex]

  @article ISI:000279136700029,
  Author = Starha, Pavel and Novotna, Radka and Travnicek, Zdenek,
  Title = X-ray structure and properties of a dinuclear palladium(II) complex
     [Pd(2)(mu-L)(4)] with four adenine-based bridges in a paddle
     wheel-like arrangement,
  Journal = INORGANIC CHEMISTRY COMMUNICATIONS,
  Year = 2010,
  Volume = 13,
  Number = 6,
  Pages = 800-803,
  Month = JUN,
  Abstract = A unique dinuclear palladium(II) complex of the general composition
     [Pd(2)(mu-L)(4)]center dot xDMF (DMF = N,N'-dimethylformamide, x=2 for
     la, x = 4 for 1b) was prepared by a reaction of K(2)[Pd(mal)(2)] and
     two molar equivalents of 2-chloro-N6-benzyl-9-isopropyladenine (HL); mal
     stands for the malonate dianion. The prepared complex was fully
     characterized by elemental analysis, molar conductivity measurements,
     IR. Raman and NMR spectroscopies, ESI + mass spectrometry, TG/DTA
     thermal studies (for la), and by a single crystal X-ray analysis (for
     1b). The results revealed that both metal centres are bridged by four
     N6-deprotonated2-chloro-N6-benzyl-9-isopropyladenine molecules (L) in a
     paddle wheel-like arrangement with the Pd1 ... Pd1A separation of
     2.7532(4) angstrom. Each of the L molecules is coordinated to the Pd(II)
     ions through its N6 and N7 atoms. The geometry around each of the
     central atoms can be described as distorted square-planar formed by two
     N6 and two N7 atoms. The [Pd(2)(mu-L)(4)]center dot xDMF complex
     represents the first dinuclear transition metal complex with two central
     ions bridged by four adenine derivatives coordinated through their N6
     and N7 atoms. (C) 2010 Elsevier By. All rights reserved.,
  DOI = 10.1016/j.inoche.2010.04.001,
  ISSN = 1387-7003,
  Unique-ID = ISI:000279136700029,
  

• R. Novotna, Z. Travnicek, and I. Popa, “X-ray crystallographic and NMR study of the tautomerism in kinetin,
  kinetin riboside and their derivatives: A comparison between the solid
  state and solution,” JOURNAL OF MOLECULAR STRUCTURE, vol. 963, iss. 2-3, pp. 202-210, 2010.
  [Bibtex]

  @article ISI:000274867800017,
  Author = Novotna, Radka and Travnicek, Zdenek and Popa, Igor,
  Title = X-ray crystallographic and NMR study of the tautomerism in kinetin,
     kinetin riboside and their derivatives: A comparison between the solid
     state and solution,
  Journal = JOURNAL OF MOLECULAR STRUCTURE,
  Year = 2010,
  Volume = 963,
  Number = 2-3,
  Pages = 202-210,
  Month = JAN 29,
  Abstract = N6-furfuryladenine (kinetin, 1), 2-chloro-N6-furfuryladenine (2),
     N6-furfuryladenosine (kinetin riboside, 3) and
     2-chloro-N6-(5-methylfurfuryl)adenosine (4) have been prepared and their
     structural properties have been studied using a single crystal X-ray
     analysis (2, 4) and multinuclear 1D and 2D NMR spectroscopy (1-4). The
     molecular structure of 2 revealed the presence of the 3H-amino and
     7H-amino tautomeric forms with the occupancy of 82(3)\%, and 18(3)\%,
     respectively, for the corresponding hydrogen. The NMR study revealed the
     presence of tautomeric equilibria in 1, 2 and 4 in dimethyl sulfoxide or
     N,N'-dimethylformamide solutions at 300 K and 340 K. It has been found
     that the 9H-amino/7H-amino, 1H,7H-imino/1H,9H-imino and
     9H-amino/7H-amino, and amino/1H-imino equilibria exist in 1, 2, and 4,
     respectively. The presence of a tautomeric equilibrium has not been
     observed in the case of 3. (c) 2009 Elsevier B.V. All rights reserved.,
  DOI = 10.1016/j.molstruc.2009.10.036,
  ISSN = 0022-2860,
  Unique-ID = ISI:000274867800017,