Regional Centre of Advanced Technologies and Materials

Email: zdenek.dvorak@upol.cz
Adresa: Šlechtitelů 11,771 46 Olomouc
Telefon: (+420) 585634903
Fax: (+420) 585 634 905

Vzdělání, kvalifikace a průběh praxe:
Mgr. – 1992-1997   Analytická chemie, PřF, Univerzita Palackého v Olomouci
Ph.D. – 1997-2001  Lékařská chemie a biochemie, LF, Univerzita Palackého v Olomouci
RNDr. – 2004          Analytická chemie, PřF, Univerzita Palackého v Olomouci (RNDr.)
Doc – 2006               Lékařská chemie a biochemie, LF, Univerzita Palackého v Olomouci
prof. – 2010         jmenován profesorem biochemie, PřF, Univerzita Palackého v Olomouci
1999-2010          Toxikolog, Soudně-lékařské oddělení, Fakultní nemocnice Olomouc
2002-2006      Vědecký pracovník, Ústav lékařské chemie a biochemie, LF Univerzity      Palackého v Olomouci
2007-2008    Docent, Ústav lékařské chemie a biochemie, LF Univerzity Palackého v Olomouci
2008-nyní      Docent/profesor, vedoucí Katedry buněčné biologie a genetiky, PřF Univerzity Palackého v Olomouci

Oblast výzkumu:
Lékové interakce, Metabolismus léčiv, Molekulární farmakologie a toxikologie

Publikační aktivita:
Počet publikací (WoS): 85
Počet citací (WoS): 536 s vyloučením autocitací
H-index: 18
Skripta: 3

Zahraniční pobyty:
1998 (3 měsíce), 2000 (3 měsíce), 2002-2003 (1 rok), 2005 (2 týdny), 2006 (2 týdny), 2007 (3 měsíce) Detoxication et Physiopathologie Hepatique, Institut National de la Sante Et de la Recherche Medicale, INSERM U128, CNRS, Montpellier, France.

Další aktivity:

Granty:
Projekt ESF – MŠMT (OPVK) – 3, Projekt GAČR – 2, Post-doktorský projekt GAČR – 1, Bilaterální projekt MŠMT Česko-Maďarsko – 1, Projekt FRVŠ – 1, Vnitřní grant LF UP – 1

Členství ve společnostech:
Česká společnost chemická, Česká společnost pro experimentální a klinickou farmakologii a toxikologii, Society for Medicinal Plant Research (GA), American Society for Pharmacology and Experimental Therapeutics (ASPET)

Ocenění:

Cena za farmacii 2001; udělena Francouzskou ambasádou v Praze a firmou Aventis
Cena děkana LF UP za nejlepší studentskou vědeckou práci za rok 2001
Cena Sigma-Aldrich za rok 2004
Cena Josefa V. Koštíře za významný přínos na poli biochemie a molekulární biologie v letech 2002-2003
Cena České společnosti pro experimentální a klinickou farmakologii a toxikologii, za nejlepší přehledový článek za rok 2010.

Členství v komisích a recenzní činnost:
Člen komise (roky 2005; 2006; 2008; 2009; 2010; 2011) pro obhajoby projektů Fondu rozvoje vysokých škol na PřF UP v Olomouci., Člen redakční rady časopisu Open Drug Metabolism Journal (Bentham Science Publishers), Člen stálého panelu oponentů časopisu Current Drug Metabolism (Bentham Science Publishers), Člen vědeckého výboru pro geneticky modifikované potraviny a krmiva při Ministerstvu zemědělství ČR (2007-nyní), Člen Vědecké rady Přírodovědecké fakulty UP (2010-nyní), Člen Bioetické komise při Radě pro výzkum, vývoj a inovace, poradního orgánu vlády ČR (2010-nyní), Člen oborové rady doktorského studijního programu Lékařská chemie a biochemie na LF UP (2007-nyní), Předseda oborové rady doktorského studijního programu Biologie – obor Molekulární a buněčná biologie na PřF UP (2010-nyní)

Vybrané publikace:

Krausova L., Stejskalova L., Wang H., Vrzal R., Dvorak Z., Mani S., Pavek P. (2011) Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.Biochem Pharmacol (in press).
Stejskalova L., Vecerova L., Perez L.M., Vrzal R., Dvorak Z., Nachtigal P., Pavek P. (2011) Aryl hydrocarbon receptor (AHR) and Aryl hydrocarbon nuclear translocator (ARNT) expression in the human and rat placentas and transcription activity in human trophoblast cultures. Toxicol Sci 123(1):26-36.
Rulcova A., Prokopova I., Krausova L., Bitman M., Vrzal R., Dvorak Z., Blahos J., Pavek P. (2010) Stereoselective interactions of warfarin enantiomers with Pregnane X nuclear (PXR) receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes. J Thromb Haemost 8(12):2708-2717.
Dvorak Z., Pavek P. (2010) Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev 42(4):621-635.
Monostory K., Pascussi J.M., Kobori L., Dvorak Z. (2009) Hormonal regulation of CYP1A expression. Drug Metab Rev 41(4):547-572.
Dvorak Z. and Pavek P. (2008) Comment on “The role of redox-sensitive transcription factors NF-kB and AP-1 in the modulation of the Cyp1A1 gene by mercury, lead and copper” Free Radic Biol Med 45(6):939
Cvek B. and Dvorak Z. (2008) The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor? Drug Discov Today 13(15-16):716-722.
Dvorak Z., Vrzal R., Henklova P., Jancova P., Anzenbacherova E., Maurel P., Svecova L., Pavek P., Ehrmann J., Havlik R., Bednar P., Lemr K., Ulrichova J. (2008) JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes. Biochem Pharmacol 75(2):580-588.
Vrzal R., Ulrichová J., Dvořák Z., Pávek P. (2007) Glucocorticoid receptor functions in HeLa cells are perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD). Drug Metab Lett 1(4):311-314.
Cvek B., Dvořák Z. (2007) Targeting of Nuclear Factor-kB and Proteasome by Dithiocarbamate Complexes with Metals. Curr Pharm Des 13(30): 3155-3167.

Show publications

Publications

2012

A. Kamenickova, R. Vrzal, and Z. Dvorak, “Effects of ready to drink teas on AhR- and PXR-mediated expression of
cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and
primary human hepatocytes,” FOOD CHEMISTRY, vol. 131, iss. 4, pp. 1201-1206, 2012.
[Bibtex]

@article ISI:000298273200017,
Author = Kamenickova, Alzbeta and Vrzal, Radim and Dvorak, Zdenek,
Title = Effects of ready to drink teas on AhR- and PXR-mediated expression of
   cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and
   primary human hepatocytes,
Journal = FOOD CHEMISTRY,
Year = 2012,
Volume = 131,
Number = 4,
Pages = 1201-1206,
Month = APR 15,
DOI = 10.1016/j.foodchem.2011.09.104,
ISSN = 0308-8146,
Unique-ID = ISI:000298273200017,

2011

A. Novotna, P. Petr, and Z. Dvorak, “Novel Stably Transfected Gene Reporter Human Hepatoma Cell Line for
Assessment of Aryl Hydrocarbon Receptor Transcriptional Activity:
Construction and Characterization,” ENVIRONMENTAL SCIENCE & TECHNOLOGY, vol. 45, iss. 23, pp. 10133-10139, 2011.
[Bibtex]

@article ISI:000297382700045,
Author = Novotna, Arleta and Petr, Pavek and Dvorak, Zdenek,
Title = Novel Stably Transfected Gene Reporter Human Hepatoma Cell Line for
   Assessment of Aryl Hydrocarbon Receptor Transcriptional Activity:
   Construction and Characterization,
Journal = ENVIRONMENTAL SCIENCE \& TECHNOLOGY,
Year = 2011,
Volume = 45,
Number = 23,
Pages = 10133-10139,
Month = DEC 1,
DOI = 10.1021/es2029334,
ISSN = 0013-936X,
Unique-ID = ISI:000297382700045,

L. Krausova, L. Stejskaova, H. Wang, R. Vrzal, Z. Dvorak, S. Mani, and P. Pavek, “Metformin suppresses pregnane X receptor (PXR)-regulated transactivation
of CYP3A4 gene,” BIOCHEMICAL PHARMACOLOGY, vol. 82, iss. 11, pp. 1771-1780, 2011.
[Bibtex]

@article ISI:000296931400026,
Author = Krausova, Lucie and Stejskaova, Lucie and Wang, Hongwei and Vrzal, Radim
   and Dvorak, Zdenek and Mani, Sridhar and Pavek, Petr,
Title = Metformin suppresses pregnane X receptor (PXR)-regulated transactivation
   of CYP3A4 gene,
Journal = BIOCHEMICAL PHARMACOLOGY,
Year = 2011,
Volume = 82,
Number = 11,
Pages = 1771-1780,
Month = DEC 1,
DOI = 10.1016/j.bcp.2011.08.023,
ISSN = 0006-2952,
Unique-ID = ISI:000296931400026,

A. Novotna, A. Doricakova, R. Vrzal, P. Pavek, and Z. Dvorak, “Construction and characterization of hepatocyte nuclear factor
HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2
cells,” EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 669, iss. 1-3, pp. 45-50, 2011.
[Bibtex]

@article ISI:000296989500007,
Author = Novotna, Aneta and Doricakova, Aneta and Vrzal, Radim and Pavek, Petr
   and Dvorak, Zdenek,
Title = Construction and characterization of hepatocyte nuclear factor
   HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2
   cells,
Journal = EUROPEAN JOURNAL OF PHARMACOLOGY,
Year = 2011,
Volume = 669,
Number = 1-3,
Pages = 45-50,
Month = NOV 1,
DOI = 10.1016/j.ejphar.2011.07.049,
ISSN = 0014-2999,
Unique-ID = ISI:000296989500007,

L. Stejskalova, L. Vecerova, L. M. Perez, R. Vrzal, Z. Dvorak, P. Nachtigal, and P. Pavek, “Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Nuclear Translocator
Expression in Human and Rat Placentas and Transcription Activity in
Human Trophoblast Cultures,” TOXICOLOGICAL SCIENCES, vol. 123, iss. 1, pp. 26-36, 2011.
[Bibtex]

@article ISI:000294557500003,
Author = Stejskalova, Lucie and Vecerova, Lenka and Perez, Laura Mesa and Vrzal,
   Radim and Dvorak, Zdenek and Nachtigal, Petr and Pavek, Petr,
Title = Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Nuclear Translocator
   Expression in Human and Rat Placentas and Transcription Activity in
   Human Trophoblast Cultures,
Journal = TOXICOLOGICAL SCIENCES,
Year = 2011,
Volume = 123,
Number = 1,
Pages = 26-36,
Month = SEP,
DOI = 10.1093/toxsci/kfr150,
ISSN = 1096-6080,
Unique-ID = ISI:000294557500003,

Z. Dvorak, A. Kamenickova, and R. Vrzal, “Examination of extracts from iced-teas on regulatory pathways of
drug-metabolizing enzymes in human hepatocytes and cell lines,” TOXICOLOGY LETTERS, vol. 205, iss. 1, pp. S140, 2011.
[Bibtex]

@article ISI:000293814500447,
Author = Dvorak, Z. and Kamenickova, A. and Vrzal, R.,
Title = Examination of extracts from iced-teas on regulatory pathways of
   drug-metabolizing enzymes in human hepatocytes and cell lines,
Journal = TOXICOLOGY LETTERS,
Year = 2011,
Volume = 205,
Number = 1,
Pages = S140,
Month = AUG 28,
Note = 47th Congress of the European-Societies-of-Toxicology, Paris, FRANCE,
   AUG 28-31, 2011,
Organization = European Soc Toxicol,
DOI = 10.1016/j.toxlet.2011.05.497,
ISSN = 0378-4274,
Unique-ID = ISI:000293814500447,

M. Bitman, Z. Dvorak, R. Vrzal, L. Stejskalova, and P. Pavek, “The cross-talk of extracellular signal-regulated protein kinase (ERK)
and pregnane X receptor (PXR) and its effect on expression of CYP3A4 and
MDR1 genes in primary human hepatocytes and hepatoma cell lines,” TOXICOLOGY LETTERS, vol. 205, iss. 1, pp. S293, 2011.
[Bibtex]

@article ISI:000293814500938,
Author = Bitman, M. and Dvorak, Z. and Vrzal, R. and Stejskalova, L. and Pavek,
   P.,
Title = The cross-talk of extracellular signal-regulated protein kinase (ERK)
   and pregnane X receptor (PXR) and its effect on expression of CYP3A4 and
   MDR1 genes in primary human hepatocytes and hepatoma cell lines,
Journal = TOXICOLOGY LETTERS,
Year = 2011,
Volume = 205,
Number = 1,
Pages = S293,
Month = AUG 28,
Note = 47th Congress of the European-Societies-of-Toxicology, Paris, FRANCE,
   AUG 28-31, 2011,
Organization = European Soc Toxicol,
DOI = 10.1016/j.toxlet.2011.05.990,
ISSN = 0378-4274,
Unique-ID = ISI:000293814500938,

L. Stejskalova, L. Vecerova, R. Vrzal, Z. Dvorak, P. Nachtigal, and P. Pavek, “AHR and ARNT expression in the human and rat placentas and their
transcription activity in human trophoblast cultures in transactivation
AHR battery genes,” TOXICOLOGY LETTERS, vol. 205, iss. 1, pp. S300, 2011.
[Bibtex]

@article ISI:000293814500961,
Author = Stejskalova, L. and Vecerova, L. and Vrzal, R. and Dvorak, Z. and
   Nachtigal, P. and Pavek, P.,
Title = AHR and ARNT expression in the human and rat placentas and their
   transcription activity in human trophoblast cultures in transactivation
   AHR battery genes,
Journal = TOXICOLOGY LETTERS,
Year = 2011,
Volume = 205,
Number = 1,
Pages = S300,
Month = AUG 28,
Note = 47th Congress of the European-Societies-of-Toxicology, Paris, FRANCE,
   AUG 28-31, 2011,
Organization = European Soc Toxicol,
DOI = 10.1016/j.toxlet.2011.05.1013,
ISSN = 0378-4274,
Unique-ID = ISI:000293814500961,

B. Cvek and Z. Dvorak, “The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of
Bortezomib,” CURRENT PHARMACEUTICAL DESIGN, vol. 17, iss. 15, pp. 1483-1499, 2011.
[Bibtex]

@article ISI:000295455800010,
Author = Cvek, Boris and Dvorak, Zdenek,
Title = The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of
   Bortezomib,
Journal = CURRENT PHARMACEUTICAL DESIGN,
Year = 2011,
Volume = 17,
Number = 15,
Pages = 1483-1499,
Month = MAY,
ISSN = 1381-6128,
Unique-ID = ISI:000295455800010,

K. Wlcek, M. Svoboda, J. Riha, S. Zakaria, U. Olszewski, Z. Dvorak, F. Sellner, I. Ellinger, W. Jaeger, and T. Thalhammer, “The analysis of organic anion transporting polypeptide (OATP) mRNA and
protein patterns in primary and metastatic liver cancer,” CANCER BIOLOGY & THERAPY, vol. 11, iss. 9, pp. 801-811, 2011.
[Bibtex]

@article ISI:000290088100003,
Author = Wlcek, Katrin and Svoboda, Martin and Riha, Juliane and Zakaria, Susanna
   and Olszewski, Ulrike and Dvorak, Zdenek and Sellner, Franz and
   Ellinger, Isabella and Jaeger, Walter and Thalhammer, Theresia,
Title = The analysis of organic anion transporting polypeptide (OATP) mRNA and
   protein patterns in primary and metastatic liver cancer,
Journal = CANCER BIOLOGY \& THERAPY,
Year = 2011,
Volume = 11,
Number = 9,
Pages = 801-811,
Month = MAY 1,
DOI = 10.4161/cbt.11.9.15176,
ISSN = 1538-4047,
Unique-ID = ISI:000290088100003,

Z. Dvorak, “Drug-drug interactions by azole antifungals: Beyond a dogma of CYP3A4
enzyme activity inhibition,” TOXICOLOGY LETTERS, vol. 202, iss. 2, pp. 129-132, 2011.
[Bibtex]

@article ISI:000289708000007,
Author = Dvorak, Zdenek,
Title = Drug-drug interactions by azole antifungals: Beyond a dogma of CYP3A4
   enzyme activity inhibition,
Journal = TOXICOLOGY LETTERS,
Year = 2011,
Volume = 202,
Number = 2,
Pages = 129-132,
Month = APR 25,
DOI = 10.1016/j.toxlet.2011.01.027,
ISSN = 0378-4274,
Unique-ID = ISI:000289708000007,

Z. Dvorak, P. Starha, and Z. Travnicek, “Evaluation of in vitro cytotoxicity of 6-benzylaminopurine carboplatin
derivatives against human cancer cell lines and primary human
hepatocytes,” TOXICOLOGY IN VITRO, vol. 25, iss. 3, pp. 652-656, 2011.
[Bibtex]

@article ISI:000288933100008,
Author = Dvorak, Zdenek and Starha, Pavel and Travnicek, Zdenek,
Title = Evaluation of in vitro cytotoxicity of 6-benzylaminopurine carboplatin
   derivatives against human cancer cell lines and primary human
   hepatocytes,
Journal = TOXICOLOGY IN VITRO,
Year = 2011,
Volume = 25,
Number = 3,
Pages = 652-656,
Month = APR,
DOI = 10.1016/j.tiv.2011.01.002,
ISSN = 0887-2333,
Unique-ID = ISI:000288933100008,

R. Vrzal, A. Doricakova, A. Novotna, P. Bachleda, M. Bitman, P. Pavek, and Z. Dvorak, “Valproic acid augments vitamin D receptor-mediated induction of CYP24 by
vitamin D3: A possible cause of valproic acid-induced osteomalacia?,” TOXICOLOGY LETTERS, vol. 200, iss. 3, pp. 146-153, 2011.
[Bibtex]

@article ISI:000287216900003,
Author = Vrzal, Radim and Doricakova, Aneta and Novotna, Aneta and Bachleda, Petr
   and Bitman, Michal and Pavek, Petr and Dvorak, Zdenek,
Title = Valproic acid augments vitamin D receptor-mediated induction of CYP24 by
   vitamin D3: A possible cause of valproic acid-induced osteomalacia?,
Journal = TOXICOLOGY LETTERS,
Year = 2011,
Volume = 200,
Number = 3,
Pages = 146-153,
Month = FEB 5,
DOI = 10.1016/j.toxlet.2010.11.008,
ISSN = 0378-4274,
Unique-ID = ISI:000287216900003,

K. Monostory and Z. Dvorak, “Steroid Regulation of Drug-Metabolizing Cytochromes P450,” CURRENT DRUG METABOLISM, vol. 12, iss. 2, pp. 154-172, 2011.
[Bibtex]

@article ISI:000289085500007,
Author = Monostory, Katalin and Dvorak, Zdenek,
Title = Steroid Regulation of Drug-Metabolizing Cytochromes P450,
Journal = CURRENT DRUG METABOLISM,
Year = 2011,
Volume = 12,
Number = 2,
Pages = 154-172,
Month = FEB,
ISSN = 1389-2002,
Unique-ID = ISI:000289085500007,

L. Stejskalova, Z. Dvorak, and P. Pavek, “Endogenous and Exogenous Ligands of Aryl Hydrocarbon Receptor: Current
State of Art,” CURRENT DRUG METABOLISM, vol. 12, iss. 2, pp. 198-212, 2011.
[Bibtex]

@article ISI:000289085500010,
Author = Stejskalova, Lucie and Dvorak, Zdenek and Pavek, Petr,
Title = Endogenous and Exogenous Ligands of Aryl Hydrocarbon Receptor: Current
   State of Art,
Journal = CURRENT DRUG METABOLISM,
Year = 2011,
Volume = 12,
Number = 2,
Pages = 198-212,
Month = FEB,
ISSN = 1389-2002,
Unique-ID = ISI:000289085500010,

Z. Dvorak, “Hot Topic: Cross-Talk Between Endogenous Compounds and Regulatory
Pathways of Drug Metabolism,” CURRENT DRUG METABOLISM, vol. 12, iss. 2, pp. 70, 2011.
[Bibtex]

@article ISI:000289085500001,
Author = Dvorak, Zdenek,
Title = Hot Topic: Cross-Talk Between Endogenous Compounds and Regulatory
   Pathways of Drug Metabolism,
Journal = CURRENT DRUG METABOLISM,
Year = 2011,
Volume = 12,
Number = 2,
Pages = 70,
Month = FEB,
ISSN = 1389-2002,
Unique-ID = ISI:000289085500001,

J. Brtko and Z. Dvorak, “Role of Retinoids, Rexinoids and Thyroid Hormone in the Expression of
Cytochrome P450 Enzymes,” CURRENT DRUG METABOLISM, vol. 12, iss. 2, pp. 71-88, 2011.
[Bibtex]

@article ISI:000289085500002,
Author = Brtko, Julius and Dvorak, Zdenek,
Title = Role of Retinoids, Rexinoids and Thyroid Hormone in the Expression of
   Cytochrome P450 Enzymes,
Journal = CURRENT DRUG METABOLISM,
Year = 2011,
Volume = 12,
Number = 2,
Pages = 71-88,
Month = FEB,
ISSN = 1389-2002,
Unique-ID = ISI:000289085500002,

Z. Dvorak and R. Vrzal, “Berberine reduces insulin resistance: the roles for glucocorticoid
receptor and aryl hydrocarbon receptor,” FERTILITY AND STERILITY, vol. 95, iss. 2, pp. E7, 2011.
[Bibtex]

@article ISI:000286419000001,
Author = Dvorak, Zdenek and Vrzal, Radim,
Title = Berberine reduces insulin resistance: the roles for glucocorticoid
   receptor and aryl hydrocarbon receptor,
Journal = FERTILITY AND STERILITY,
Year = 2011,
Volume = 95,
Number = 2,
Pages = E7,
Month = FEB,
DOI = 10.1016/j.fertnstert.2010.11.014,
ISSN = 0015-0282,
Unique-ID = ISI:000286419000001,

R. Buchtik, Z. Travnicek, J. Vanco, R. Herchel, and Z. Dvorak, “Synthesis, characterization, DNA interaction and cleavage, and in vitro
cytotoxicity of copper(II) mixed-ligand complexes with
2-phenyl-3-hydroxy-4(1H)-quinolinone,” DALTON TRANSACTIONS, vol. 40, iss. 37, pp. 9404-9412, 2011.
[Bibtex]

@article ISI:000294666700010,
Author = Buchtik, Roman and Travnicek, Zdenek and Vanco, Jan and Herchel, Radovan
   and Dvorak, Zdenek,
Title = Synthesis, characterization, DNA interaction and cleavage, and in vitro
   cytotoxicity of copper(II) mixed-ligand complexes with
   2-phenyl-3-hydroxy-4(1H)-quinolinone,
Journal = DALTON TRANSACTIONS,
Year = 2011,
Volume = 40,
Number = 37,
Pages = 9404-9412,
DOI = 10.1039/c1dt10674k,
ISSN = 1477-9226,
Unique-ID = ISI:000294666700010,

2010

A. Rulcova, I. Prokopova, L. Krausova, M. Bitman, R. Vrzal, Z. Dvorak, J. Blahos, and P. Pavek, “Stereoselective interactions of warfarin enantiomers with the pregnane X
nuclear receptor in gene regulation of major drug-metabolizing
cytochrome P450 enzymes,” JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 8, iss. 12, pp. 2708-2717, 2010.
[Bibtex]

@article ISI:000285110700016,
Author = Rulcova, A. and Prokopova, I. and Krausova, L. and Bitman, M. and Vrzal,
   R. and Dvorak, Z. and Blahos, J. and Pavek, P.,
Title = Stereoselective interactions of warfarin enantiomers with the pregnane X
   nuclear receptor in gene regulation of major drug-metabolizing
   cytochrome P450 enzymes,
Journal = JOURNAL OF THROMBOSIS AND HAEMOSTASIS,
Year = 2010,
Volume = 8,
Number = 12,
Pages = 2708-2717,
Month = DEC,
DOI = 10.1111/j.1538-7836.2010.04036.x,
ISSN = 1538-7933,
Unique-ID = ISI:000285110700016,

Z. Dvorak and P. Pavek, “Regulation of drug-metabolizing cytochrome P450 enzymes by
glucocorticoids,” DRUG METABOLISM REVIEWS, vol. 42, iss. 4, pp. 621-635, 2010.
[Bibtex]

@article ISI:000284506600004,
Author = Dvorak, Zdenek and Pavek, Peotr,
Title = Regulation of drug-metabolizing cytochrome P450 enzymes by
   glucocorticoids,
Journal = DRUG METABOLISM REVIEWS,
Year = 2010,
Volume = 42,
Number = 4,
Pages = 621-635,
Month = NOV,
DOI = 10.3109/03602532.2010.484462,
ISSN = 0360-2532,
Unique-ID = ISI:000284506600004,

P. Bachleda, R. Vrzal, and Z. Dvorak, “Resveratrol Enhances NK Cell Cytotoxicity: Possible Role for Aryl
Hydrocarbon Receptor,” JOURNAL OF CELLULAR PHYSIOLOGY, vol. 225, iss. 2, pp. 289-290, 2010.
[Bibtex]

@article ISI:000283003400001,
Author = Bachleda, Petr and Vrzal, Radim and Dvorak, Zdenek,
Title = Resveratrol Enhances NK Cell Cytotoxicity: Possible Role for Aryl
   Hydrocarbon Receptor,
Journal = JOURNAL OF CELLULAR PHYSIOLOGY,
Year = 2010,
Volume = 225,
Number = 2,
Pages = 289-290,
Month = NOV,
DOI = 10.1002/jcp.22233,
ISSN = 0021-9541,
Unique-ID = ISI:000283003400001,

A. Novotna, A. Doricakova, R. Vrzal, P. Maurel, P. Pavek, and Z. Dvorak, “Investigation of Orlistat effects on PXR activation and CYP3A4
expression in primary human hepatocytes and human intestinal LS174T
cells,” EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 41, iss. 2, pp. 276-280, 2010.
[Bibtex]

@article ISI:000281995200010,
Author = Novotna, Aneta and Doricakova, Aneta and Vrzal, Radim and Maurel,
   Patrick and Pavek, Petr and Dvorak, Zdenek,
Title = Investigation of Orlistat effects on PXR activation and CYP3A4
   expression in primary human hepatocytes and human intestinal LS174T
   cells,
Journal = EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,
Year = 2010,
Volume = 41,
Number = 2,
Pages = 276-280,
Month = OCT 9,
DOI = 10.1016/j.ejps.2010.06.019,
ISSN = 0928-0987,
Unique-ID = ISI:000281995200010,

Z. Travnicek, P. Starha, I. Popa, R. Vrzal, and Z. Dvorak, “Roscovitine-based CDK inhibitors acting as N-donor ligands in the
platinum(II) oxalato complexes: Preparation, characterization and in
vitro cytotoxicity,” EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, iss. 10, pp. 4609-4614, 2010.
[Bibtex]

@article ISI:000282112700024,
Author = Travnicek, Zdenek and Starha, Pavel and Popa, Igor and Vrzal, Radim and
   Dvorak, Zdenek,
Title = Roscovitine-based CDK inhibitors acting as N-donor ligands in the
   platinum(II) oxalato complexes: Preparation, characterization and in
   vitro cytotoxicity,
Journal = EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,
Year = 2010,
Volume = 45,
Number = 10,
Pages = 4609-4614,
Month = OCT,
DOI = 10.1016/j.ejmech.2010.07.025,
ISSN = 0223-5234,
Unique-ID = ISI:000282112700024,

R. Vrzal, P. Starha, Z. Dvorak, and Z. Travnicek, “Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II)
and palladium(II) oxalato complexes with adenine derivatives as carrier
ligands,” JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 104, iss. 10, pp. 1130-1132, 2010.
[Bibtex]

@article ISI:000281525200017,
Author = Vrzal, Radim and Starha, Pavel and Dvorak, Zdenek and Travnicek, Zdenek,
Title = Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II)
   and palladium(II) oxalato complexes with adenine derivatives as carrier
   ligands,
Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
Year = 2010,
Volume = 104,
Number = 10,
Pages = 1130-1132,
Month = OCT,
DOI = 10.1016/j.jinorgbio.2010.07.002,
ISSN = 0162-0134,
Unique-ID = ISI:000281525200017,

Z. Dvorak, “Berberine: A multipotent remedy with unknown cellular target?,” POULTRY SCIENCE, vol. 89, iss. 9, pp. 1787, 2010.
[Bibtex]

@article ISI:000280895400001,
Author = Dvorak, Z.,
Title = Berberine: A multipotent remedy with unknown cellular target?,
Journal = POULTRY SCIENCE,
Year = 2010,
Volume = 89,
Number = 9,
Pages = 1787,
Month = SEP 1,
DOI = 10.3382/ps.2010-00701,
ISSN = 0032-5791,
Unique-ID = ISI:000280895400001,

L. Stejskalova, L. Vecerova, L. M. Perez, L. Hahnova, P. Nachtigal, R. Vrzal, Z. Dvorak, and P. Pavek, “Activity of Aryl hydrocarbon receptor (AhR) in the placental trophoblast
and expression of AhR and its translocator ARNT expression in rat and
human placentas during pregnancy,” DRUG METABOLISM REVIEWS, vol. 42, iss. 1, pp. 155, 2010.
[Bibtex]

@article ISI:000281147700274,
Author = Stejskalova, Lucie and Vecerova, Lenka and Perez, Laura Messa and
   Hahnova, Lenka and Nachtigal, Petr and Vrzal, Radim and Dvorak, Zdenek
   and Pavek, Petr,
Title = Activity of Aryl hydrocarbon receptor (AhR) in the placental trophoblast
   and expression of AhR and its translocator ARNT expression in rat and
   human placentas during pregnancy,
Journal = DRUG METABOLISM REVIEWS,
Year = 2010,
Volume = 42,
Number = 1,
Pages = 155,
Month = AUG,
Note = 9th International Meeting of the
   International-Society-for-the-Study-of-Xenobiotics(ISSX), Istanbul,
   TURKEY, SEP 04-08, 2010,
Organization = Int Soc Study Xenobiot,
ISSN = 0360-2532,
Unique-ID = ISI:000281147700274,

M. Bitman, R. Vrzal, Z. Dvorak, L. Stejskalova, and P. Pavek, “The Influence of Extracellular Signal-Regulated Protein Kinase (ERK) on
Pregnane X Receptor-Mediated Expression of CYP3A4 and MDR1 Genes in
Hepatocellular Carcinoma Cell Lines and in Primary Human Hepatocytes,” DRUG METABOLISM REVIEWS, vol. 42, iss. 1, pp. 159, 2010.
[Bibtex]

@article ISI:000281147700281,
Author = Bitman, Michal and Vrzal, Radim and Dvorak, Zdenek and Stejskalova,
   Lucie and Pavek, Petr,
Title = The Influence of Extracellular Signal-Regulated Protein Kinase (ERK) on
   Pregnane X Receptor-Mediated Expression of CYP3A4 and MDR1 Genes in
   Hepatocellular Carcinoma Cell Lines and in Primary Human Hepatocytes,
Journal = DRUG METABOLISM REVIEWS,
Year = 2010,
Volume = 42,
Number = 1,
Pages = 159,
Month = AUG,
Note = 9th International Meeting of the
   International-Society-for-the-Study-of-Xenobiotics(ISSX), Istanbul,
   TURKEY, SEP 04-08, 2010,
Organization = Int Soc Study Xenobiot,
ISSN = 0360-2532,
Unique-ID = ISI:000281147700281,

M. Stiborova, V. Martinek, M. Svobodova, J. Sistkova, Z. Dvorak, J. Ulrichova, V. Simanek, E. Frei, H. H. Schmeiser, D. H. Phillips, and V. M. Arlt, “Mechanisms of the Different DNA Adduct Forming Potentials of the Urban
Air Pollutants 2-Nitrobenzanthrone and Carcinogenic 3-Nitrobenzanthrone,” CHEMICAL RESEARCH IN TOXICOLOGY, vol. 23, iss. 7, pp. 1192-1201, 2010.
[Bibtex]

@article ISI:000279928000007,
Author = Stiborova, Marie and Martinek, Vaclav and Svobodova, Martina and
   Sistkova, Jana and Dvorak, Zdenek and Ulrichova, Jitka and Simanek,
   Vilim and Frei, Eva and Schmeiser, Heinz H. and Phillips, David H. and
   Arlt, Volker M.,
Title = Mechanisms of the Different DNA Adduct Forming Potentials of the Urban
   Air Pollutants 2-Nitrobenzanthrone and Carcinogenic 3-Nitrobenzanthrone,
Journal = CHEMICAL RESEARCH IN TOXICOLOGY,
Year = 2010,
Volume = 23,
Number = 7,
Pages = 1192-1201,
Month = JUL,
DOI = 10.1021/tx100052d,
ISSN = 0893-228X,
Unique-ID = ISI:000279928000007,

R. Vrzal, A. Novotna, A. Doricakova, M. Bitmann, P. Pavek, and Z. Dvorak, “Valproic acid potentiates vitamin D receptor-mediated induction of CYP24
gene – A consequence for drug-induced osteomalacia,” FEBS JOURNAL, vol. 277, iss. 1, pp. 153, 2010.
[Bibtex]

@article ISI:000278565100539,
Author = Vrzal, R. and Novotna, A. and Doricakova, A. and Bitmann, M. and Pavek,
   P. and Dvorak, Z.,
Title = Valproic acid potentiates vitamin D receptor-mediated induction of CYP24
   gene - A consequence for drug-induced osteomalacia,
Journal = FEBS JOURNAL,
Year = 2010,
Volume = 277,
Number = 1,
Pages = 153,
Month = JUN,
Note = 35th Congress of the Federation-of-European-Biochemical-Societies,
   Gothenburg, SWEDEN, JUN 26-JUL 01, 2010,
ISSN = 1742-464X,
Unique-ID = ISI:000278565100539,

R. Vrzal, P. Pavek, and Z. Dvorak, “Investigation of benzodiazepines and zolpidem effects on the expression
of cychromes P450 CYP1A1, CYP1A2 and CYP3A4 in primary cultures of human
hepatocytes,” FEBS JOURNAL, vol. 277, iss. 1, pp. 153, 2010.
[Bibtex]

@article ISI:000278565100538,
Author = Vrzal, R. and Pavek, P. and Dvorak, Z.,
Title = Investigation of benzodiazepines and zolpidem effects on the expression
   of cychromes P450 CYP1A1, CYP1A2 and CYP3A4 in primary cultures of human
   hepatocytes,
Journal = FEBS JOURNAL,
Year = 2010,
Volume = 277,
Number = 1,
Pages = 153,
Month = JUN,
Note = 35th Congress of the Federation-of-European-Biochemical-Societies,
   Gothenburg, SWEDEN, JUN 26-JUL 01, 2010,
ISSN = 1742-464X,
Unique-ID = ISI:000278565100538,

R. Vrzal, S. Gerbal-Chaloin, P. Maurel, and Z. Dvorak, “Comparative Effects of Microtubules Disruption on Glucocorticoid
Receptor Functions in Proliferating and Quiescent Cells,” INTERNATIONAL JOURNAL OF TOXICOLOGY, vol. 29, iss. 3, pp. 326-335, 2010.
[Bibtex]

@article ISI:000278124800011,
Author = Vrzal, Radim and Gerbal-Chaloin, Sabine and Maurel, Patrick and Dvorak,
   Zdenek,
Title = Comparative Effects of Microtubules Disruption on Glucocorticoid
   Receptor Functions in Proliferating and Quiescent Cells,
Journal = INTERNATIONAL JOURNAL OF TOXICOLOGY,
Year = 2010,
Volume = 29,
Number = 3,
Pages = 326-335,
Month = MAY,
DOI = 10.1177/1091581810366486,
ISSN = 1091-5818,
Unique-ID = ISI:000278124800011,

R. Vrzal, K. Kubesova, P. Pavek, and Z. Dvorak, “Benzodiazepines medazepam and midazolam are activators of pregnane X
receptor and weak inducers of CYP3A4: Investigation in primary cultures
of human hepatocytes and hepatocarcinoma cell lines,” TOXICOLOGY LETTERS, vol. 193, iss. 2, pp. 183-188, 2010.
[Bibtex]

@article ISI:000276175200009,
Author = Vrzal, Radim and Kubesova, Katerina and Pavek, Petr and Dvorak, Zdenek,
Title = Benzodiazepines medazepam and midazolam are activators of pregnane X
   receptor and weak inducers of CYP3A4: Investigation in primary cultures
   of human hepatocytes and hepatocarcinoma cell lines,
Journal = TOXICOLOGY LETTERS,
Year = 2010,
Volume = 193,
Number = 2,
Pages = 183-188,
Month = MAR 15,
DOI = 10.1016/j.toxlet.2010.01.004,
ISSN = 0378-4274,
Unique-ID = ISI:000276175200009,

Z. Dvorak, R. Vrzal, P. Starha, A. Klanicova, and Z. Travnicek, “Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine
derivatives on AhR and PXR dependent expression of cytochromes P450
CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes,” TOXICOLOGY IN VITRO, vol. 24, iss. 2, pp. 425-429, 2010.
[Bibtex]

@article ISI:000275991700011,
Author = Dvorak, Zdenek and Vrzal, Radim and Starha, Pavel and Klanicova, Alena
   and Travnicek, Zdenek,
Title = Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine
   derivatives on AhR and PXR dependent expression of cytochromes P450
   CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes,
Journal = TOXICOLOGY IN VITRO,
Year = 2010,
Volume = 24,
Number = 2,
Pages = 425-429,
Month = MAR,
DOI = 10.1016/j.tiv.2009.10.012,
ISSN = 0887-2333,
Unique-ID = ISI:000275991700011,

P. Pavek, K. Pospechova, L. Svecova, Z. Syrova, L. Stejskalova, J. Blazkova, Z. Dvorak, and J. Blahos, “Intestinal cell-specific vitamin D receptor (VDR)-mediated
transcriptional regulation of CYP3A4 gene,” BIOCHEMICAL PHARMACOLOGY, vol. 79, iss. 2, pp. 277-287, 2010.
[Bibtex]

@article ISI:000273506900022,
Author = Pavek, Petr and Pospechova, Katerina and Svecova, Lucie and Syrova,
   Zdenka and Stejskalova, Lucie and Blazkova, Jana and Dvorak, Zdenek and
   Blahos, Jaroslav,
Title = Intestinal cell-specific vitamin D receptor (VDR)-mediated
   transcriptional regulation of CYP3A4 gene,
Journal = BIOCHEMICAL PHARMACOLOGY,
Year = 2010,
Volume = 79,
Number = 2,
Pages = 277-287,
Month = JAN 15,
DOI = 10.1016/j.bcp.2009.08.017,
ISSN = 0006-2952,
Unique-ID = ISI:000273506900022,

2009

P. Bachleda, R. Vrzal, J. Pivnicka, B. Cvek, and Z. Dvorak, “Examination of Zolpidem effects on AhR- and PXR-dependent expression of
drug-metabolizing cytochromes P450 in primary cultures of human
hepatocytes,” TOXICOLOGY LETTERS, vol. 191, iss. 1, pp. 74-78, 2009.
[Bibtex]

@article ISI:000272276700011,
Author = Bachleda, Petr and Vrzal, Radim and Pivnicka, Jakub and Cvek, Boris and
   Dvorak, Zdenek,
Title = Examination of Zolpidem effects on AhR- and PXR-dependent expression of
   drug-metabolizing cytochromes P450 in primary cultures of human
   hepatocytes,
Journal = TOXICOLOGY LETTERS,
Year = 2009,
Volume = 191,
Number = 1,
Pages = 74-78,
Month = DEC 1,
DOI = 10.1016/j.toxlet.2009.08.009,
ISSN = 0378-4274,
Unique-ID = ISI:000272276700011,

A. Belic, M. Temesvari, K. Kohalmy, R. Vrzal, Z. Dvorak, D. Rozman, and K. Monostory, “Investigation of the CYP2C9 Induction Profile in Human Hepatocytes by
Combining Experimental and Modelling Approaches,” CURRENT DRUG METABOLISM, vol. 10, iss. 10, pp. 1066-1074, 2009.
[Bibtex]

@article ISI:000275149900001,
Author = Belic, Ales and Temesvari, Manna and Kohalmy, Krisztina and Vrzal, Radim
   and Dvorak, Zdenek and Rozman, Damjana and Monostory, Katalin,
Title = Investigation of the CYP2C9 Induction Profile in Human Hepatocytes by
   Combining Experimental and Modelling Approaches,
Journal = CURRENT DRUG METABOLISM,
Year = 2009,
Volume = 10,
Number = 10,
Pages = 1066-1074,
Month = DEC,
ISSN = 1389-2002,
Unique-ID = ISI:000275149900001,

K. Monostory, J. Pascussi, L. Kobori, and Z. Dvorak, “Hormonal regulation of CYP1A expression,” DRUG METABOLISM REVIEWS, vol. 41, iss. 4, pp. 547-572, 2009.
[Bibtex]

@article ISI:000280164500001,
Author = Monostory, Katalin and Pascussi, Jean-Marc and Kobori, Laszlo and
   Dvorak, Zdenek,
Title = Hormonal regulation of CYP1A expression,
Journal = DRUG METABOLISM REVIEWS,
Year = 2009,
Volume = 41,
Number = 4,
Pages = 547-572,
Month = NOV,
DOI = 10.3109/03602530903112284,
ISSN = 0360-2532,
Unique-ID = ISI:000280164500001,

P. Bachleda, R. Vrzal, and Z. Dvorak, “Activation of MAPKs influences the expression of drug-metabolizing
enzymes in primary human hepatocytes,” GENERAL PHYSIOLOGY AND BIOPHYSICS, vol. 28, iss. 3, pp. 316-320, 2009.
[Bibtex]

@article ISI:000272335700013,
Author = Bachleda, Petr and Vrzal, Radim and Dvorak, Zdenek,
Title = Activation of MAPKs influences the expression of drug-metabolizing
   enzymes in primary human hepatocytes,
Journal = GENERAL PHYSIOLOGY AND BIOPHYSICS,
Year = 2009,
Volume = 28,
Number = 3,
Pages = 316-320,
Month = SEP,
DOI = 10.4149/gpb\_2009\_03\_316,
ISSN = 0231-5882,
Unique-ID = ISI:000272335700013,

R. Vrzal, L. Stejskalova, K. Monostory, P. Maurel, P. Bachleda, P. Pavek, and Z. Dvorak, “Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1
and CYP1A2 expression and activity in primary cultures of human
hepatocytes,” CHEMICO-BIOLOGICAL INTERACTIONS, vol. 179, iss. 2-3, pp. 288-296, 2009.
[Bibtex]

@article ISI:000265364600028,
Author = Vrzal, Radim and Stejskalova, Lucie and Monostory, Katalin and Maurel,
   Patrick and Bachleda, Petr and Pavek, Petr and Dvorak, Zdenek,
Title = Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1
   and CYP1A2 expression and activity in primary cultures of human
   hepatocytes,
Journal = CHEMICO-BIOLOGICAL INTERACTIONS,
Year = 2009,
Volume = 179,
Number = 2-3,
Pages = 288-296,
Month = MAY 15,
DOI = 10.1016/j.cbi.2008.10.035,
ISSN = 0009-2797,
Unique-ID = ISI:000265364600028,

M. Bitman, R. Vrzal, K. Pospechova, L. Svecova, L. Cygalova, Z. Dvorak, and P. Pavek, “Effect of Valproic Acid on Extracellular Mitogen-activated Protein
Kinase Pathways and Major Transcriptional Factors in Hepatoma Cell Lines
and Primary Human Hepatocytes,” DRUG METABOLISM REVIEWS, vol. 41, iss. 1, pp. 54, 2009.
[Bibtex]

@article ISI:000280164800041,
Author = Bitman, Michal and Vrzal, Radim and Pospechova, Katerina and Svecova,
   Lucie and Cygalova, Lenka and Dvorak, Zdenek and Pavek, Petr,
Title = Effect of Valproic Acid on Extracellular Mitogen-activated Protein
   Kinase Pathways and Major Transcriptional Factors in Hepatoma Cell Lines
   and Primary Human Hepatocytes,
Journal = DRUG METABOLISM REVIEWS,
Year = 2009,
Volume = 41,
Number = 1,
Pages = 54,
Month = MAY,
Note = 11th European Regional ISSX Meeting, Lisbon, PORTUGAL, MAY 17-20, 2009,
ISSN = 0360-2532,
Unique-ID = ISI:000280164800041,

K. Pospechova, V. Rozehnal, L. Stejskalova, R. Vrzal, N. Pospisilova, G. Jamborova, K. May, W. Siegmund, Z. Dvorak, P. Nachtigal, V. Semecky, and P. Pavek, “Expression and activity of vitamin D receptor in the human placenta and
in choriocarcinoma BeWo and JEG-3 cell lines,” MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 299, iss. 2, pp. 178-187, 2009.
[Bibtex]

@article ISI:000263662500006,
Author = Pospechova, Katerina and Rozehnal, Veronika and Stejskalova, Lucie and
   Vrzal, Radim and Pospisilova, Nada and Jamborova, Gabriela and May,
   Karen and Siegmund, Werner and Dvorak, Zdenek and Nachtigal, Petr and
   Semecky, Vladimir and Pavek, Petr,
Title = Expression and activity of vitamin D receptor in the human placenta and
   in choriocarcinoma BeWo and JEG-3 cell lines,
Journal = MOLECULAR AND CELLULAR ENDOCRINOLOGY,
Year = 2009,
Volume = 299,
Number = 2,
Pages = 178-187,
Month = FEB 27,
DOI = 10.1016/j.mce.2008.12.003,
ISSN = 0303-7207,
Unique-ID = ISI:000263662500006,

2008

P. Henklova, R. Vrzal, B. Papouskova, P. Bednar, P. Jancova, E. Anzenbacherova, J. Ulrichova, P. Maurel, P. Pavek, and Z. Dvorak, “SB203580, a pharmacological inhibitor of p38 MAP kinase transduction
pathway activates ERK and JNK MAP kinases in primary cultures of human
hepatocytes,” EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 593, iss. 1-3, pp. 16-23, 2008.
[Bibtex]

@article ISI:000259508100003,
Author = Henklova, Pavla and Vrzal, Radim and Papouskova, Barbora and Bednar,
   Petr and Jancova, Petra and Anzenbacherova, Eva and Ulrichova, Jitka and
   Maurel, Patrick and Pavek, Petr and Dvorak, Zdenek,
Title = SB203580, a pharmacological inhibitor of p38 MAP kinase transduction
   pathway activates ERK and JNK MAP kinases in primary cultures of human
   hepatocytes,
Journal = EUROPEAN JOURNAL OF PHARMACOLOGY,
Year = 2008,
Volume = 593,
Number = 1-3,
Pages = 16-23,
Month = SEP 28,
DOI = 10.1016/j.ejphar.2008.07.007,
ISSN = 0014-2999,
Unique-ID = ISI:000259508100003,

Z. Dvorak and P. Pavek, “Comment on “The role of redox-sensitive transcription factors NF-kappa
B and AP-1 in the modulation of the Cyp1A1 gene by mercury, lead, and
copper”,” FREE RADICAL BIOLOGY AND MEDICINE, vol. 45, iss. 6, pp. 939, 2008.
[Bibtex]

@article ISI:000259357300024,
Author = Dvorak, Zdenek and Pavek, Petr,
Title = Comment on ``The role of redox-sensitive transcription factors NF-kappa
   B and AP-1 in the modulation of the Cyp1A1 gene by mercury, lead, and
   copper'',
Journal = FREE RADICAL BIOLOGY AND MEDICINE,
Year = 2008,
Volume = 45,
Number = 6,
Pages = 939,
Month = SEP 15,
DOI = 10.1016/j.freeradbiomed.2008.06.002,
ISSN = 0891-5849,
Unique-ID = ISI:000259357300024,

B. Cvek and Z. Dvorak, “The value of proteasome inhibition in cancer,” DRUG DISCOVERY TODAY, vol. 13, iss. 15-16, pp. 716-722, 2008.
[Bibtex]

@article ISI:000258801100012,
Author = Cvek, Boris and Dvorak, Zdenek,
Title = The value of proteasome inhibition in cancer,
Journal = DRUG DISCOVERY TODAY,
Year = 2008,
Volume = 13,
Number = 15-16,
Pages = 716-722,
Month = AUG,
DOI = 10.1016/j.drudis.2008.05.003,
ISSN = 1359-6446,
Unique-ID = ISI:000258801100012,

E. Vrublova, J. Vostalova, R. Vecera, B. Klejdus, D. Stejskaj, P. Kosina, A. Zdarilova, A. Svobodova, V. Lichnovsky, P. Anzenbacher, Z. Dvorak, J. Vicar, V. Simanek, and J. Ulrichova, “The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot
study,” FOOD AND CHEMICAL TOXICOLOGY, vol. 46, iss. 7, pp. 2546-2553, 2008.
[Bibtex]

@article ISI:000257480200036,
Author = Vrublova, Eva and Vostalova, Jitka and Vecera, Rostislav and Klejdus,
   Borivoj and Stejskaj, David and Kosina, Pavel and Zdarilova, Adela and
   Svobodova, Alena and Lichnovsky, Vaclav and Anzenbacher, Pavel and
   Dvorak, Zdenek and Vicar, Jaroslav and Simanek, Vilim and Ulrichova,
   Jitka,
Title = The toxicity and pharmacokinetics of dihydrosanguinarine in rat: A pilot
   study,
Journal = FOOD AND CHEMICAL TOXICOLOGY,
Year = 2008,
Volume = 46,
Number = 7,
Pages = 2546-2553,
Month = JUL,
DOI = 10.1016/j.fct.2008.04.013,
ISSN = 0278-6915,
Unique-ID = ISI:000257480200036,

P. Bachleda and Z. Dvorak, “Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are
not appropriate tools for studies of drug metabolism because they
activate aryl hydrocarbon receptor,” GENERAL PHYSIOLOGY AND BIOPHYSICS, vol. 27, iss. 2, pp. 143-145, 2008.
[Bibtex]

@article ISI:000258040300009,
Author = Bachleda, P. and Dvorak, Z.,
Title = Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are
   not appropriate tools for studies of drug metabolism because they
   activate aryl hydrocarbon receptor,
Journal = GENERAL PHYSIOLOGY AND BIOPHYSICS,
Year = 2008,
Volume = 27,
Number = 2,
Pages = 143-145,
Month = JUN,
ISSN = 0231-5882,
Unique-ID = ISI:000258040300009,

P. Henklova, R. Vrzal, J. Ulrichova, and Z. Dvorak, “Role of mitogen-activated protein kinases in aryl hydrocarbon receptor
signaling,” CHEMICO-BIOLOGICAL INTERACTIONS, vol. 172, iss. 2, pp. 93-104, 2008.
[Bibtex]

@article ISI:000255100000001,
Author = Henklova, Pavla and Vrzal, Radim and Ulrichova, Jitka and Dvorak, Zdenk,
Title = Role of mitogen-activated protein kinases in aryl hydrocarbon receptor
   signaling,
Journal = CHEMICO-BIOLOGICAL INTERACTIONS,
Year = 2008,
Volume = 172,
Number = 2,
Pages = 93-104,
Month = MAR 27,
DOI = 10.1016/j.cbi.2007.12.005,
ISSN = 0009-2797,
Unique-ID = ISI:000255100000001,

R. Vrzal, M. Daujat-Chavanieu, J. Pascussi, J. Ulrichova, P. Maurel, and Z. Dvorak, “Microtubules-interfering agents restrict aryl hydrocarbon
receptor-mediated CYP1A2 induction in primary cultures of human
hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor,” EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 581, iss. 3, pp. 244-254, 2008.
[Bibtex]

@article ISI:000253752600002,
Author = Vrzal, Radim and Daujat-Chavanieu, Martine and Pascussi, Jean-Marc and
   Ulrichova, Jitka and Maurel, Patrick and Dvorak, Zdenek,
Title = Microtubules-interfering agents restrict aryl hydrocarbon
   receptor-mediated CYP1A2 induction in primary cultures of human
   hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor,
Journal = EUROPEAN JOURNAL OF PHARMACOLOGY,
Year = 2008,
Volume = 581,
Number = 3,
Pages = 244-254,
Month = MAR 10,
DOI = 10.1016/j.ejphar.2007.11.059,
ISSN = 0014-2999,
Unique-ID = ISI:000253752600002,

P. Pavek and Z. Dvorak, “Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing
enzymes of the cytochrome P450 superfamily in human extrahepatic tissues,” CURRENT DRUG METABOLISM, vol. 9, iss. 2, pp. 129-143, 2008.
[Bibtex]

@article ISI:000253936700004,
Author = Pavek, Petr and Dvorak, Zdenek,
Title = Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing
   enzymes of the cytochrome P450 superfamily in human extrahepatic tissues,
Journal = CURRENT DRUG METABOLISM,
Year = 2008,
Volume = 9,
Number = 2,
Pages = 129-143,
Month = FEB,
DOI = 10.2174/138920008783571774,
ISSN = 1389-2002,
Unique-ID = ISI:000253936700004,

T. Onica, K. Nichols, M. Larin, L. Ng, A. Maslen, Z. Dvorak, J. Pascussi, M. Vilarem, P. Maurel, and G. M. Kirby, “Dexamethasone-mediated up-regulation of human CYP2A6 involves the
glucocorticoid receptor and increased binding of hepatic nuclear factor
4 alpha to the proximal promoter,” MOLECULAR PHARMACOLOGY, vol. 73, iss. 2, pp. 451-460, 2008.
[Bibtex]

@article ISI:000252597300019,
Author = Onica, Tania and Nichols, Kathleen and Larin, Meghan and Ng, Lorraine
   and Maslen, Ann and Dvorak, Zdenek and Pascussi, Jean-Marc and Vilarem,
   Marie-Josee and Maurel, Patrick and Kirby, Gordon M.,
Title = Dexamethasone-mediated up-regulation of human CYP2A6 involves the
   glucocorticoid receptor and increased binding of hepatic nuclear factor
   4 alpha to the proximal promoter,
Journal = MOLECULAR PHARMACOLOGY,
Year = 2008,
Volume = 73,
Number = 2,
Pages = 451-460,
Month = FEB,
DOI = 10.1124/mol.107.039354,
ISSN = 0026-895X,
Unique-ID = ISI:000252597300019,

L. Svecova, R. Vrzal, L. Burysek, E. Anzenbacherova, L. Cerveny, J. Grim, F. Trejtnar, J. Kunes, M. Pour, F. Staud, P. Anzenbacher, Z. Dvorak, and P. Pavek, “Azole antimycotics differentially affect rifampicin-induced pregnane x
receptor-mediated CYP3A4 gene expression,” DRUG METABOLISM AND DISPOSITION, vol. 36, iss. 2, pp. 339-348, 2008.
[Bibtex]

@article ISI:000252634900016,
Author = Svecova, Lucie and Vrzal, Radim and Burysek, Ladislav and
   Anzenbacherova, Eva and Cerveny, Lukas and Grim, Jiri and Trejtnar,
   Frantisek and Kunes, Jiri and Pour, Milan and Staud, Frantisek and
   Anzenbacher, Pavel and Dvorak, Zdenek and Pavek, Petr,
Title = Azole antimycotics differentially affect rifampicin-induced pregnane x
   receptor-mediated CYP3A4 gene expression,
Journal = DRUG METABOLISM AND DISPOSITION,
Year = 2008,
Volume = 36,
Number = 2,
Pages = 339-348,
Month = FEB,
DOI = 10.1124/dmd.107.018341,
ISSN = 0090-9556,
Unique-ID = ISI:000252634900016,

Z. Dvorak, R. Vrzal, P. Henklova, P. Jancova, E. Anzenbacheroua, P. Maurel, L. Svecova, P. Pavek, J. Ehrmann, R. Havlik, P. Bednar, K. Lemr, and J. Ulrichova, “JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon
receptor and induces CYP1A1 and CYP1A2 genes in primary human
hepatocytes,” BIOCHEMICAL PHARMACOLOGY, vol. 75, iss. 2, pp. 580-588, 2008.
[Bibtex]

@article ISI:000252842300024,
Author = Dvorak, Zdenek and Vrzal, Radim and Henklova, Paula and Jancova, Petra
   and Anzenbacheroua, Eva and Maurel, Patrick and Svecova, Lucie and
   Pavek, Petr and Ehrmann, Jiri and Havlik, Roman and Bednar, Petr and
   Lemr, Karel and Ulrichova, Jitka,
Title = JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon
   receptor and induces CYP1A1 and CYP1A2 genes in primary human
   hepatocytes,
Journal = BIOCHEMICAL PHARMACOLOGY,
Year = 2008,
Volume = 75,
Number = 2,
Pages = 580-588,
Month = JAN 15,
DOI = 10.1016/j.bcp.2007.09.013,
ISSN = 0006-2952,
Unique-ID = ISI:000252842300024,

Z. Dvorak, R. Vrzal, P. Pavek, and J. Ulrichova, “An evidence for regulatory cross-talk between aryl hydrocarbon receptor
and glucocorticoid receptor in HepG2 cells,” PHYSIOLOGICAL RESEARCH, vol. 57, iss. 3, pp. 427-435, 2008.
[Bibtex]

@article ISI:000257270900014,
Author = Dvorak, Z. and Vrzal, R. and Pavek, P. and Ulrichova, J.,
Title = An evidence for regulatory cross-talk between aryl hydrocarbon receptor
   and glucocorticoid receptor in HepG2 cells,
Journal = PHYSIOLOGICAL RESEARCH,
Year = 2008,
Volume = 57,
Number = 3,
Pages = 427-435,
ISSN = 0862-8408,
Unique-ID = ISI:000257270900014,

Z. Dvorak, R. Vrzal, P. Henklova, P. Jancova, E. Anzenbacherova, P. Maurel, P. Pavek, P. Bednar, and J. Ulrichova, “JNK PHARMACOLOGICAL INHIBITOR SP600125 IS A PARTIAL AGONIST OF HUMAN
ARYL HYDROCARBON RECEPTOR AND INDUCES CYP1A1 AND CYP1A2 GENES IN PRIMARY
HUMAN HEPATOCYTES,” DRUG METABOLISM REVIEWS, vol. 40, pp. 147, 2008.
[Bibtex]

@article ISI:000265257400128,
Author = Dvorak, Zdenek and Vrzal, Radim and Henklova, Pavla and Jancova, Petra
   and Anzenbacherova, Eva and Maurel, Patrick and Pavek, Petr and Bednar,
   Petr and Ulrichova, Jitka,
Title = JNK PHARMACOLOGICAL INHIBITOR SP600125 IS A PARTIAL AGONIST OF HUMAN
   ARYL HYDROCARBON RECEPTOR AND INDUCES CYP1A1 AND CYP1A2 GENES IN PRIMARY
   HUMAN HEPATOCYTES,
Journal = DRUG METABOLISM REVIEWS,
Year = 2008,
Volume = 40,
Pages = 147,
Note = 10th European Regional Meeting of the
   International-Society-for-the-Study-of-Xenobiotics, Vienna, AUSTRIA, MAY
   18-21, 2008,
Organization = Int Soc Study Xenobiot,
ISSN = 0360-2532,
Unique-ID = ISI:000265257400128,

J. Vrba, Z. Dvorak, J. Ulrichova, and M. Modriansky, “Conventional protein kinase C isoenzymes undergo dephosphorylation in
neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine,” CELL BIOLOGY AND TOXICOLOGY, vol. 24, iss. 1, pp. 39-53, 2008.
[Bibtex]

@article ISI:000251969500005,
Author = Vrba, J. and Dvorak, Z. and Ulrichova, J. and Modriansky, M.,
Title = Conventional protein kinase C isoenzymes undergo dephosphorylation in
   neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine,
Journal = CELL BIOLOGY AND TOXICOLOGY,
Year = 2008,
Volume = 24,
Number = 1,
Pages = 39-53,
Month = JAN,
DOI = 10.1007/s10565-007-9014-1,
ISSN = 0742-2091,
Unique-ID = ISI:000251969500005,

R. Vrzal, P. Henklova, B. Papoukova, P. Bednar, P. Jancova, E. Anzenbacherova, J. Ulrichova, P. Maurel, P. Pavek, and Z. Dvorak, “AN INHIBITOR OF P38 MAP KINASE ACTIVATES ERK AND JNK MAP KINASES IN
PRIMARY CULTURES OF HUMAN HEPATOCYTES,” DRUG METABOLISM REVIEWS, vol. 40, pp. 146, 2008.
[Bibtex]

@article ISI:000265257400127,
Author = Vrzal, Radim and Henklova, Pavla and Papoukova, Barbora and Bednar, Petr
   and Jancova, Petra and Anzenbacherova, Eva and Ulrichova, Jitka and
   Maurel, Patrick and Pavek, Petr and Dvorak, Zdenek,
Title = AN INHIBITOR OF P38 MAP KINASE ACTIVATES ERK AND JNK MAP KINASES IN
   PRIMARY CULTURES OF HUMAN HEPATOCYTES,
Journal = DRUG METABOLISM REVIEWS,
Year = 2008,
Volume = 40,
Pages = 146,
Note = 10th European Regional Meeting of the
   International-Society-for-the-Study-of-Xenobiotics, Vienna, AUSTRIA, MAY
   18-21, 2008,
Organization = Int Soc Study Xenobiot,
ISSN = 0360-2532,
Unique-ID = ISI:000265257400127,

2007

P. Pavek, L. Cerveny, L. Svecova, M. Brysch, A. Libra, R. Vrzal, P. Nachtigal, F. Staud, J. Ulrichova, Z. Fendrich, and Z. Dvorak, “Examination of glucocorticoid receptor alpha-mediated transcriptional
regulation of P-glycoprotein, CYP3A4, and CYP2C9 genes in placental
trophoblast cell lines,” PLACENTA, vol. 28, iss. 10, pp. 1004-1011, 2007.
[Bibtex]

@article ISI:000249650500005,
Author = Pavek, P. and Cerveny, L. and Svecova, L. and Brysch, M. and Libra, A.
   and Vrzal, R. and Nachtigal, P. and Staud, F. and Ulrichova, J. and
   Fendrich, Z. and Dvorak, Z.,
Title = Examination of glucocorticoid receptor alpha-mediated transcriptional
   regulation of P-glycoprotein, CYP3A4, and CYP2C9 genes in placental
   trophoblast cell lines,
Journal = PLACENTA,
Year = 2007,
Volume = 28,
Number = 10,
Pages = 1004-1011,
Month = OCT,
DOI = 10.1016/j.placenta.2007.05.001,
ISSN = 0143-4004,
Unique-ID = ISI:000249650500005,

Z. Dvorak, M. Modriansky, J. Vrba, J. Ulrichova, V. Krystof, J. Styskala, and P. Pavek, “Evaluation of novel microtubules interfering agents myoseverin,
tubulyzine and E2GG in primary cultures of rat hepatocytes,” GENERAL PHYSIOLOGY AND BIOPHYSICS, vol. 26, iss. 3, pp. 173-180, 2007.
[Bibtex]

@article ISI:000251272400003,
Author = Dvorak, Z. and Modriansky, M. and Vrba, J. and Ulrichova, J. and
   Krystof, V. and Styskala, J. and Pavek, P.,
Title = Evaluation of novel microtubules interfering agents myoseverin,
   tubulyzine and E2GG in primary cultures of rat hepatocytes,
Journal = GENERAL PHYSIOLOGY AND BIOPHYSICS,
Year = 2007,
Volume = 26,
Number = 3,
Pages = 173-180,
Month = SEP,
ISSN = 0231-5882,
Unique-ID = ISI:000251272400003,

D. Macejova, Z. Dvorak, R. Vrzal, J. Ulrichova, S. Ondkova, and J. Brtko, “The effect of all-trans retinoic acid and/or colchicine on expression of
rexinoid and thyroid hormone nuclear receptors and their coregulators in
primary rat hepatocytes,” GENERAL PHYSIOLOGY AND BIOPHYSICS, vol. 26, iss. 3, pp. 240-242, 2007.
[Bibtex]

@article ISI:000251272400012,
Author = Macejova, D. and Dvorak, Z. and Vrzal, R. and Ulrichova, J. and Ondkova,
   S. and Brtko, J.,
Title = The effect of all-trans retinoic acid and/or colchicine on expression of
   rexinoid and thyroid hormone nuclear receptors and their coregulators in
   primary rat hepatocytes,
Journal = GENERAL PHYSIOLOGY AND BIOPHYSICS,
Year = 2007,
Volume = 26,
Number = 3,
Pages = 240-242,
Month = SEP,
ISSN = 0231-5882,
Unique-ID = ISI:000251272400012,

L. Cerveny, L. Svecova, E. Anzenbacherova, R. Vrzal, F. Staud, Z. Dvorak, J. Ulrichova, P. Anzenbacher, and P. Pavek, “Valproic acid induces CYP3A4 and MDR1 gene expression by activation of
constitutive androstane receptor and pregnane X receptor pathways,” DRUG METABOLISM AND DISPOSITION, vol. 35, iss. 7, pp. 1032-1041, 2007.
[Bibtex]

@article ISI:000247373800004,
Author = Cerveny, Lukas and Svecova, Lucie and Anzenbacherova, Eva and Vrzal,
   Radim and Staud, Frantisek and Dvorak, Zdenek and Ulrichova, Jitka and
   Anzenbacher, Pavel and Pavek, Petr,
Title = Valproic acid induces CYP3A4 and MDR1 gene expression by activation of
   constitutive androstane receptor and pregnane X receptor pathways,
Journal = DRUG METABOLISM AND DISPOSITION,
Year = 2007,
Volume = 35,
Number = 7,
Pages = 1032-1041,
Month = JUL,
DOI = 10.1124/dmd.106.014456,
ISSN = 0090-9556,
Unique-ID = ISI:000247373800004,

Z. Dvorak, R. Vrzal, J. Ulrichova, D. Macejova, S. Ondkova, and J. Brtko, “Expression, protein stability and transcriptional activity of retinoic
acid receptors are affected by microtubules interfering agents and
all-traps-retinoic acid in primary rat hepatocytes,” MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 267, iss. 1-2, pp. 89-96, 2007.
[Bibtex]

@article ISI:000245429200011,
Author = Dvorak, Zdenek and Vrzal, Radim and Ulrichova, Jitka and Macejova, Dana
   and Ondkova, Slavomira and Brtko, Julius,
Title = Expression, protein stability and transcriptional activity of retinoic
   acid receptors are affected by microtubules interfering agents and
   all-traps-retinoic acid in primary rat hepatocytes,
Journal = MOLECULAR AND CELLULAR ENDOCRINOLOGY,
Year = 2007,
Volume = 267,
Number = 1-2,
Pages = 89-96,
Month = MAR 15,
DOI = 10.1016/j.mce.2007.01.004,
ISSN = 0303-7207,
Unique-ID = ISI:000245429200011,

Z. Dvorak, P. Maurel, M-J. Vilarem, J. Ulrichova, and M. Modriansky, “Expression and transcriptional activities of nuclear receptors involved
in regulation of drug-metabolizing enzymes are not altered by
colchiceine: Focus on PXR, CAR, and GR in primary human hepatocytes,” CELL BIOLOGY AND TOXICOLOGY, vol. 23, iss. 2, pp. 63-73, 2007.
[Bibtex]

@article ISI:000243602400001,
Author = Dvorak, Z. and Maurel, P. and Vilarem, M-J and Ulrichova, J. and
   Modriansky, M.,
Title = Expression and transcriptional activities of nuclear receptors involved
   in regulation of drug-metabolizing enzymes are not altered by
   colchiceine: Focus on PXR, CAR, and GR in primary human hepatocytes,
Journal = CELL BIOLOGY AND TOXICOLOGY,
Year = 2007,
Volume = 23,
Number = 2,
Pages = 63-73,
Month = MAR,
DOI = 10.1007/s10565-006-0127-8,
ISSN = 0742-2091,
Unique-ID = ISI:000243602400001,

Z. Dvorak and V. Simanek, “Metabolism of sanguinarine: The facts and the myths,” CURRENT DRUG METABOLISM, vol. 8, iss. 2, pp. 173-176, 2007.
[Bibtex]

@article ISI:000244702800006,
Author = Dvorak, Z. and Simanek, V.,
Title = Metabolism of sanguinarine: The facts and the myths,
Journal = CURRENT DRUG METABOLISM,
Year = 2007,
Volume = 8,
Number = 2,
Pages = 173-176,
Month = FEB,
DOI = 10.2174/138920007779815959,
ISSN = 1389-2002,
Unique-ID = ISI:000244702800006,

R. Vecera, B. Klejdus, P. Kosina, J. Orolin, M. Stiborova, S. Smrcek, J. Vicar, Z. Dvorak, J. Ulrichova, V. Kuba, P. Anzenbacher, and V. Simanek, “Disposition of sanguinarine in the rat,” XENOBIOTICA, vol. 37, iss. 5, pp. 549-558, 2007.
[Bibtex]

@article ISI:000247065500007,
Author = Vecera, R. and Klejdus, B. and Kosina, P. and Orolin, J. and Stiborova,
   M. and Smrcek, S. and Vicar, J. and Dvorak, Z. and Ulrichova, J. and
   Kuba, V. and Anzenbacher, P. and Simanek, V.,
Title = Disposition of sanguinarine in the rat,
Journal = XENOBIOTICA,
Year = 2007,
Volume = 37,
Number = 5,
Pages = 549-558,
DOI = 10.1080/00498250701230542,
ISSN = 0049-8254,
Unique-ID = ISI:000247065500007,

B. Cvek and Z. Dvorak, “Targeting of nuclear Factor-kappa B and proteasome by dithiocarbamate
complexes with metals,” CURRENT PHARMACEUTICAL DESIGN, vol. 13, iss. 30, pp. 3155-3167, 2007.
[Bibtex]

@article ISI:000250570600010,
Author = Cvek, B. and Dvorak, Z.,
Title = Targeting of nuclear Factor-kappa B and proteasome by dithiocarbamate
   complexes with metals,
Journal = CURRENT PHARMACEUTICAL DESIGN,
Year = 2007,
Volume = 13,
Number = 30,
Pages = 3155-3167,
DOI = 10.2174/138161207782110390,
ISSN = 1381-6128,
Unique-ID = ISI:000250570600010,

2006

Z. Dvorak, V. Kuban, B. Klejdus, J. Hlavac, J. Vicar, J. Ulrichova, and V. Simanek, “Quaternary benzo[c]phenanthridines sanguinarine and chelerythrine: A
review of investigations from chemical and biological studies,” HETEROCYCLES, vol. 68, iss. 11, pp. 2403-2422, 2006.
[Bibtex]

@article ISI:000242707500018,
Author = Dvorak, Zdenek and Kuban, Vlastimil and Klejdus, Borivoj and Hlavac, Jan
   and Vicar, Jaroslav and Ulrichova, Jitka and Simanek, Vilim,
Title = Quaternary benzo[c]phenanthridines sanguinarine and chelerythrine: A
   review of investigations from chemical and biological studies,
Journal = HETEROCYCLES,
Year = 2006,
Volume = 68,
Number = 11,
Pages = 2403-2422,
Month = NOV 1,
ISSN = 0385-5414,
Unique-ID = ISI:000242707500018,

M. Modriansky, J. Ulrichova, and Z. Dvorak, “Microtubules and commuting receptors,” LETTERS IN DRUG DESIGN & DISCOVERY, vol. 3, iss. 8, pp. 567-568, 2006.
[Bibtex]

@article ISI:000240673200010,
Author = Modriansky, M. and Ulrichova, J. and Dvorak, Z.,
Title = Microtubules and commuting receptors,
Journal = LETTERS IN DRUG DESIGN \& DISCOVERY,
Year = 2006,
Volume = 3,
Number = 8,
Pages = 567-568,
Month = OCT,
DOI = 10.2174/157018006778194718,
ISSN = 1570-1808,
Unique-ID = ISI:000240673200010,

Z. Dvorak, A. Zdarilova, L. Sperlikova, E. Anzenbacherova, V. Simanek, and J. Ulrichova, “Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by
dioxin and phenobarbital,” TOXICOLOGY LETTERS, vol. 165, iss. 3, pp. 282-288, 2006.
[Bibtex]

@article ISI:000239496200010,
Author = Dvorak, Zdenek and Zdarilova, Adela and Sperlikova, Lucie and
   Anzenbacherova, Eva and Simanek, Vilim and Ulrichova, Jitka,
Title = Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by
   dioxin and phenobarbital,
Journal = TOXICOLOGY LETTERS,
Year = 2006,
Volume = 165,
Number = 3,
Pages = 282-288,
Month = SEP 10,
DOI = 10.1016/j.toxlet.2006.05.002,
ISSN = 0378-4274,
Unique-ID = ISI:000239496200010,

Z. Dvorak, I. Sovadinova, L. Blaha, J. P. Giesy, and J. Ulrichova, “Quaternary benzo[c]phenathridine alkaloids sanguinarine and
chelerythrine do not affect transcriptional activity of aryl hydrocarbon
receptor: Analyses in rat hepatoma cell line H4IIE.luc,” FOOD AND CHEMICAL TOXICOLOGY, vol. 44, iss. 9, pp. 1466-1473, 2006.
[Bibtex]

@article ISI:000240247100004,
Author = Dvorak, Zdenek and Sovadinova, Iva and Blaha, Ludek and Giesy, John P.
   and Ulrichova, Jitka,
Title = Quaternary benzo[c]phenathridine alkaloids sanguinarine and
   chelerythrine do not affect transcriptional activity of aryl hydrocarbon
   receptor: Analyses in rat hepatoma cell line H4IIE.luc,
Journal = FOOD AND CHEMICAL TOXICOLOGY,
Year = 2006,
Volume = 44,
Number = 9,
Pages = 1466-1473,
Month = SEP,
DOI = 10.1016/j.fct.2006.04.016,
ISSN = 0278-6915,
Unique-ID = ISI:000240247100004,

Z. Dvorak, R. Vrzal, J. Ulrichova, J. Pascussi, P. Maurel, and M. Modriansky, “Involvement of cytoskeleton in AhR-dependent CYP1A1 expression,” CURRENT DRUG METABOLISM, vol. 7, iss. 3, pp. 301-313, 2006.
[Bibtex]

@article ISI:000236692000007,
Author = Dvorak, Z and Vrzal, R and Ulrichova, J and Pascussi, JM and Maurel, P
   and Modriansky, M,
Title = Involvement of cytoskeleton in AhR-dependent CYP1A1 expression,
Journal = CURRENT DRUG METABOLISM,
Year = 2006,
Volume = 7,
Number = 3,
Pages = 301-313,
Month = APR,
DOI = 10.2174/138920006776359310,
ISSN = 1389-2002,
Unique-ID = ISI:000236692000007,

Z. Dvorak, R. Vrzal, and J. Ulrichova, “Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic
activity: A study in human keratinocytes and human hepatoma cells,” CELL BIOLOGY AND TOXICOLOGY, vol. 22, iss. 2, pp. 81-90, 2006.
[Bibtex]

@article ISI:000235928200002,
Author = Dvorak, Z and Vrzal, R and Ulrichova, J,
Title = Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic
   activity: A study in human keratinocytes and human hepatoma cells,
Journal = CELL BIOLOGY AND TOXICOLOGY,
Year = 2006,
Volume = 22,
Number = 2,
Pages = 81-90,
Month = MAR,
DOI = 10.1007/s10565-006-0017-0,
ISSN = 0742-2091,
Unique-ID = ISI:000235928200002,

A. Zdarilova, R. Vrzal, M. Rypka, J. Ulrichova, and Z. Dvorak, “Investigation of sanguinarine and chelerythrine effects on CYP1A1
expression and activity in human hepatoma cells,” FOOD AND CHEMICAL TOXICOLOGY, vol. 44, iss. 2, pp. 242-249, 2006.
[Bibtex]

@article ISI:000235599800011,
Author = Zdarilova, A and Vrzal, R and Rypka, M and Ulrichova, J and Dvorak, Z,
Title = Investigation of sanguinarine and chelerythrine effects on CYP1A1
   expression and activity in human hepatoma cells,
Journal = FOOD AND CHEMICAL TOXICOLOGY,
Year = 2006,
Volume = 44,
Number = 2,
Pages = 242-249,
Month = FEB,
DOI = 10.1016/j.fct.2005.07.006,
ISSN = 0278-6915,
Unique-ID = ISI:000235599800011,

Z. Dvorak, R. Vrzal, P. Maurel, and J. Ulrichova, “Differential effects of selected natural compounds with
anti-inflammatory activity on the glucocorticoid receptor and NF-kappa B
in HeLa cells,” CHEMICO-BIOLOGICAL INTERACTIONS, vol. 159, iss. 2, pp. 117-128, 2006.
[Bibtex]

@article ISI:000235016900004,
Author = Dvorak, Z and Vrzal, R and Maurel, P and Ulrichova, J,
Title = Differential effects of selected natural compounds with
   anti-inflammatory activity on the glucocorticoid receptor and NF-kappa B
   in HeLa cells,
Journal = CHEMICO-BIOLOGICAL INTERACTIONS,
Year = 2006,
Volume = 159,
Number = 2,
Pages = 117-128,
Month = FEB 1,
DOI = 10.1016/j.cbi.2005.10.105,
ISSN = 0009-2797,
Unique-ID = ISI:000235016900004,

A. Zdarilova, J. Malikova, Z. Dvorak, J. Ulrichova, and V. Simanek, “Quaternary isoquinoline alkaloids sanguinarine and chelerythrine. In
vitro and in vivo effects,” CHEMICKE LISTY, vol. 100, iss. 1, pp. 30-41, 2006.
[Bibtex]

@article ISI:000234992900006,
Author = Zdarilova, A and Malikova, J and Dvorak, Z and Ulrichova, J and Simanek,
   V,
Title = Quaternary isoquinoline alkaloids sanguinarine and chelerythrine. In
   vitro and in vivo effects,
Journal = CHEMICKE LISTY,
Year = 2006,
Volume = 100,
Number = 1,
Pages = 30-41,
ISSN = 0009-2770,
Unique-ID = ISI:000234992900006,

2005

Z. Dvorak, J. Ulrichova, and M. Modriansky, “Role of microtubules network in CYP genes expression,” CURRENT DRUG METABOLISM, vol. 6, iss. 6, pp. 545-552, 2005.
[Bibtex]

@article ISI:000233385100003,
Author = Dvorak, Z and Ulrichova, J and Modriansky, M,
Title = Role of microtubules network in CYP genes expression,
Journal = CURRENT DRUG METABOLISM,
Year = 2005,
Volume = 6,
Number = 6,
Pages = 545-552,
Month = DEC,
DOI = 10.2174/138920005774832623,
ISSN = 1389-2002,
Unique-ID = ISI:000233385100003,

R. Vrzal, A. Zdarilova, J. Ulrichova, L. Blaha, J. Giesy, and Z. Dvorak, “Activation of the aryl hydrocarbon receptor by berberine in HepG2 and
H4IIE cells: Biphasic effect on CYP1A1,” BIOCHEMICAL PHARMACOLOGY, vol. 70, iss. 6, pp. 925-936, 2005.
[Bibtex]

@article ISI:000231663100013,
Author = Vrzal, R and Zdarilova, A and Ulrichova, J and Blaha, L and Giesy, JP
   and Dvorak, Z,
Title = Activation of the aryl hydrocarbon receptor by berberine in HepG2 and
   H4IIE cells: Biphasic effect on CYP1A1,
Journal = BIOCHEMICAL PHARMACOLOGY,
Year = 2005,
Volume = 70,
Number = 6,
Pages = 925-936,
Month = SEP 15,
DOI = 10.1016/j.bcp.2005.06.016,
ISSN = 0006-2952,
Unique-ID = ISI:000231663100013,

Z. Dvorak, M. Modriansky, V. Simanek, J. Ulrichova, J. Vicar, J. Vrba, and D. Walterova, “Sanguinarine activates polycyclic aromatic hydrocarbon associated
metabolic pathways in human oral keratinocytes and tissues,” TOXICOLOGY LETTERS, vol. 158, iss. 2, pp. 164-165, 2005.
[Bibtex]

@article ISI:000231343300010,
Author = Dvorak, Z and Modriansky, M and Simanek, V and Ulrichova, J and Vicar, J
   and Vrba, J and Walterova, D,
Title = Sanguinarine activates polycyclic aromatic hydrocarbon associated
   metabolic pathways in human oral keratinocytes and tissues,
Journal = TOXICOLOGY LETTERS,
Year = 2005,
Volume = 158,
Number = 2,
Pages = 164-165,
Month = AUG 14,
DOI = 10.1016/j.toxlet.2005.05.010,
ISSN = 0378-4274,
Unique-ID = ISI:000231343300010,

Z. Dvorak, M. Modriansky, J. Ulrichova, P. Maurel, M. Vilarem, and J. Pascussi, “Disruption of microtubules leads to glucocorticoid receptor degradation
in HeLa cell line,” CELLULAR SIGNALLING, vol. 17, iss. 2, pp. 187-196, 2005.
[Bibtex]

@article ISI:000224930000006,
Author = Dvorak, Z and Modriansky, M and Ulrichova, J and Maurel, P and Vilarem,
   MP and Pascussi, JM,
Title = Disruption of microtubules leads to glucocorticoid receptor degradation
   in HeLa cell line,
Journal = CELLULAR SIGNALLING,
Year = 2005,
Volume = 17,
Number = 2,
Pages = 187-196,
Month = FEB,
DOI = 10.1016/j.cellsig.2004.06.010,
ISSN = 0898-6568,
Unique-ID = ISI:000224930000006,

R. Vrzal, A. Zdarilova, J. Ulrichova, and Z. Dvorak, “Short term effect of berberine on AhR transcriptional activity,” DRUG METABOLISM REVIEWS, vol. 37, iss. 1, pp. 159, 2005.
[Bibtex]

@article ISI:000232535400159,
Author = Vrzal, R and Zdarilova, A and Ulrichova, J and Dvorak, Z,
Title = Short term effect of berberine on AhR transcriptional activity,
Journal = DRUG METABOLISM REVIEWS,
Year = 2005,
Volume = 37,
Number = 1,
Pages = 159,
Note = 9th European ISSX Meeting, Nice, FRANCE, JUN 12-17, 2005,
ISSN = 0360-2532,
Unique-ID = ISI:000232535400159,

P. Kosina, P. Maurel, J. Ulrichova, and Z. Dvorak, “Effect of silybin and its glycosides on the expression of cytochromes
p450 1A2 and 3A4 in primary cultures of human hepatocytes,” JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol. 19, iss. 3, pp. 149-153, 2005.
[Bibtex]

@article ISI:000230354300002,
Author = Kosina, P and Maurel, P and Ulrichova, J and Dvorak, Z,
Title = Effect of silybin and its glycosides on the expression of cytochromes
   p450 1A2 and 3A4 in primary cultures of human hepatocytes,
Journal = JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,
Year = 2005,
Volume = 19,
Number = 3,
Pages = 149-153,
DOI = 10.1002/jbt.20066,
ISSN = 1095-6670,
Unique-ID = ISI:000230354300002,

2004

Z. Dvorak, M. Modriansky, J. Ulrichova, and P. Maurel, “Speculations on the role of the microtubule network in glucocorticoid
receptor signaling,” CELL BIOLOGY AND TOXICOLOGY, vol. 20, iss. 6, pp. 333-343, 2004.
[Bibtex]

@article ISI:000228876200002,
Author = Dvorak, Z and Modriansky, M and Ulrichova, J and Maurel, P,
Title = Speculations on the role of the microtubule network in glucocorticoid
   receptor signaling,
Journal = CELL BIOLOGY AND TOXICOLOGY,
Year = 2004,
Volume = 20,
Number = 6,
Pages = 333-343,
Month = NOV,
DOI = 10.1007/s10565-004-0088-8,
ISSN = 0742-2091,
Unique-ID = ISI:000228876200002,

Z. Dvorak, M. Modriansky, P. Maurel, J. Pascussi, and J. Ulrichova, “Anti-glucocorticoid behavior of anti-inflammatory drug colchicine: a
paradoxical phenomenon at molecular level,” TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 197, iss. 3, pp. 887, 2004.
[Bibtex]

@article ISI:000222348900819,
Author = Dvorak, Z and Modriansky, M and Maurel, P and Pascussi, JM and
   Ulrichova, J,
Title = Anti-glucocorticoid behavior of anti-inflammatory drug colchicine: a
   paradoxical phenomenon at molecular level,
Journal = TOXICOLOGY AND APPLIED PHARMACOLOGY,
Year = 2004,
Volume = 197,
Number = 3,
Pages = 887,
Month = JUN 15,
Note = 10th International Congress of Toxicology, Tampere, FINLAND, JUL 11-15,
   2004,
ISSN = 0041-008X,
Unique-ID = ISI:000222348900819,

2003

Z. Dvorak, M. Modriansky, L. Pichard-Garcia, P. Balaguer, M. Vilarem, J. Ulrichova, P. Maurel, and J. Pascussi, “Colchicine down-regulates cytochrome P4502B6, 2C8, 2C9, and 3A4 in human
hepatocytes by affecting their glucocorticoid receptor-mediated
regulation,” MOLECULAR PHARMACOLOGY, vol. 64, iss. 1, pp. 160-169, 2003.
[Bibtex]

@article ISI:000183613100019,
Author = Dvorak, Z and Modriansky, M and Pichard-Garcia, L and Balaguer, P and
   Vilarem, MJ and Ulrichova, J and Maurel, P and Pascussi, JM,
Title = Colchicine down-regulates cytochrome P4502B6, 2C8, 2C9, and 3A4 in human
   hepatocytes by affecting their glucocorticoid receptor-mediated
   regulation,
Journal = MOLECULAR PHARMACOLOGY,
Year = 2003,
Volume = 64,
Number = 1,
Pages = 160-169,
Month = JUL,
DOI = 10.1124/mol.64.1.160,
ISSN = 0026-895X,
Unique-ID = ISI:000183613100019,

Z. Dvorak, P. Kosina, D. Walterova, V. Simanek, P. Bachleda, and J. Ulrichova, “Primary cultures of human hepatocytes as a tool in cytotoxicity studies:
cell protection against model toxins by flavonolignans obtained from
Silybum marianum,” TOXICOLOGY LETTERS, vol. 137, iss. 3, pp. 201-212, 2003.
[Bibtex]

@article ISI:000180833600009,
Author = Dvorak, Z and Kosina, P and Walterova, D and Simanek, V and Bachleda, P
   and Ulrichova, J,
Title = Primary cultures of human hepatocytes as a tool in cytotoxicity studies:
   cell protection against model toxins by flavonolignans obtained from
   Silybum marianum,
Journal = TOXICOLOGY LETTERS,
Year = 2003,
Volume = 137,
Number = 3,
Pages = 201-212,
Month = FEB 3,
ISSN = 0378-4274,
Unique-ID = ISI:000180833600009,

Z. Dvorak, M. Modriansky, J. Pascussi, P. Balaguer, J. Ulrichova, and P. Maurel, “Cytoskeleton dependency of glucocorticoid receptor regulated cytochrome
P450 expression: Differential effect of colchicine and nocodazole,” DRUG METABOLISM REVIEWS, vol. 35, iss. 1, pp. 294, 2003.
[Bibtex]

@article ISI:000182128400291,
Author = Dvorak, Z and Modriansky, M and Pascussi, JM and Balaguer, P and
   Ulrichova, J and Maurel, P,
Title = Cytoskeleton dependency of glucocorticoid receptor regulated cytochrome
   P450 expression: Differential effect of colchicine and nocodazole,
Journal = DRUG METABOLISM REVIEWS,
Year = 2003,
Volume = 35,
Number = 1,
Pages = 294,
Note = 8th European Meeting of the
   International-Society-for-the-Study-of-Xenobiotics (ISSX), DIJON,
   FRANCE, APR 27-MAY 01, 2003,
Organization = Int Soc Study Xenobiotics,
ISSN = 0360-2532,
Unique-ID = ISI:000182128400291,

J. Pascussi, Z. Dvorak, S. Gerbal-Chaloin, E. Assenat, P. Maurel, and M. Vilarem, “Pathophysiological factors affecting CAR gene expression,” DRUG METABOLISM REVIEWS, vol. 35, iss. 4, pp. 255-268, 2003.
[Bibtex]

@article ISI:000187608800001,
Author = Pascussi, JM and Dvorak, Z and Gerbal-Chaloin, S and Assenat, E and
   Maurel, P and Vilarem, MJ,
Title = Pathophysiological factors affecting CAR gene expression,
Journal = DRUG METABOLISM REVIEWS,
Year = 2003,
Volume = 35,
Number = 4,
Pages = 255-268,
Note = 8th European ISSX Meeting, DIJON, FRANCE, APR 27-MAY 01, 2003,
DOI = 10.1081/DMR-120026394,
ISSN = 0360-2532,
Unique-ID = ISI:000187608800001,

2002

R. Zuber, M. Modriansky, Z. Dvorak, P. Rohovsky, J. Ulrichova, V. Simanek, and P. Anzenbacher, “Effect of silybin and its congeners on human liver microsomal cytochrome
P450 activities,” PHYTOTHERAPY RESEARCH, vol. 16, iss. 7, pp. 632-638, 2002.
[Bibtex]

@article ISI:000179225800005,
Author = Zuber, R and Modriansky, M and Dvorak, Z and Rohovsky, P and Ulrichova,
   J and Simanek, V and Anzenbacher, P,
Title = Effect of silybin and its congeners on human liver microsomal cytochrome
   P450 activities,
Journal = PHYTOTHERAPY RESEARCH,
Year = 2002,
Volume = 16,
Number = 7,
Pages = 632-638,
Month = NOV,
DOI = 10.1002/ptr.1000,
ISSN = 0951-418X,
Unique-ID = ISI:000179225800005,

Z. Dvorak, J. Ulrichova, L. Pichard-Garcia, M. Modriansky, and P. Maurel, “Comparative effect of colchicine and colchiceine on cytotoxicity and CYP
gene expression in primary human hepatocytes,” TOXICOLOGY IN VITRO, vol. 16, iss. 3, pp. 219-227, 2002.
[Bibtex]

@article ISI:000176538700002,
Author = Dvorak, Z and Ulrichova, J and Pichard-Garcia, L and Modriansky, M and
   Maurel, P,
Title = Comparative effect of colchicine and colchiceine on cytotoxicity and CYP
   gene expression in primary human hepatocytes,
Journal = TOXICOLOGY IN VITRO,
Year = 2002,
Volume = 16,
Number = 3,
Pages = 219-227,
Month = JUN,
DOI = 10.1016/S0887-2333(02)00004-8,
ISSN = 0887-2333,
Unique-ID = ISI:000176538700002,

2001

J. Ulrichova, Z. Dvorak, J. Vicar, J. Lata, J. Smrzova, A. Sedo, and V. Simanek, “Cytotoxicity of natural compounds in hepatocyte cell culture models -
The case of quaternary benzo[c]phenanthridine alkaloids,” TOXICOLOGY LETTERS, vol. 125, iss. 1-3, pp. 125-132, 2001.
[Bibtex]

@article ISI:000172529800015,
Author = Ulrichova, J and Dvorak, Z and Vicar, J and Lata, J and Smrzova, J and
   Sedo, A and Simanek, V,
Title = Cytotoxicity of natural compounds in hepatocyte cell culture models -
   The case of quaternary benzo[c]phenanthridine alkaloids,
Journal = TOXICOLOGY LETTERS,
Year = 2001,
Volume = 125,
Number = 1-3,
Pages = 125-132,
Month = DEC 15,
DOI = 10.1016/S0378-4274(01)00430-1,
ISSN = 0378-4274,
Unique-ID = ISI:000172529800015,

J. Smrzova, Z. Dvorak, J. Lata, P. Dite, M. Machala, L. Blaha, V. Simanek, and J. Ulrichova, “Optimisation of porcine hepatocyte cryopreservation by comparison of
viability and enzymatic activity of fresh and cryopreserved cells,” ACTA VETERINARIA BRNO, vol. 70, iss. 2, pp. 141-147, 2001.
[Bibtex]

@article ISI:000170118200004,
Author = Smrzova, J and Dvorak, Z and Lata, J and Dite, P and Machala, M and
   Blaha, L and Simanek, V and Ulrichova, J,
Title = Optimisation of porcine hepatocyte cryopreservation by comparison of
   viability and enzymatic activity of fresh and cryopreserved cells,
Journal = ACTA VETERINARIA BRNO,
Year = 2001,
Volume = 70,
Number = 2,
Pages = 141-147,
Month = JUN,
DOI = 10.2754/avb200170020141,
ISSN = 0001-7213,
Unique-ID = ISI:000170118200004,

1998

P. Kosina, Z. Dvorak, and D. Walterova, “Expression of cytochromes P450 1A2 and 3A4: effect of silybin and its
beta-glycosides,” CHEMICAL PAPERS, vol. 52, iss. SI, pp. 564, 1998.
[Bibtex]

@article ISI:000076671700257,
Author = Kosina, P and Dvorak, Z and Walterova, D,
Title = Expression of cytochromes P450 1A2 and 3A4: effect of silybin and its
   beta-glycosides,
Journal = CHEMICAL PAPERS,
Year = 1998,
Volume = 52,
Number = SI,
Pages = 564,
Note = XVI Biochemical Congress of the
   Slovak-and-Czech-Society-of-Biochemistry-and-Molecular-Biology, STARA
   LESNA, SLOVAKIA, OCT 12-15, 1998,
Organization = Slovak \& Czech Soc Biochem \& Molec Biol,
ISSN = 0366-6352,
Unique-ID = ISI:000076671700257,

Zdeněk Dvořák