Regionální centrum pokročilých technologií a materiálů

Email: vancoj@vfu.cz, jan.vanco@upol.cz
Adresa: 17. listopadu 12, 771 46 Olomouc
Telefon: (+420) 58 563 4351
Fax: (+420) 58 563 4357

Vzdělání a kvalifikace:
1996–2001  Farmácia, Univerzita Komenského v Bratislave, Slovenská Republika (Mgr.)
2001             Rigorózna skúška, Farmácia, Univerzita Komenského v Bratislave, Slovenská Republika (PharmDr.)
2001–2011  Doktorský studijní program Farmacie, obor Farmaceutická chemie, Ústav chemických léčiv, Farmaceutická fakulta VFU Brno (Ph.D.)
2002-2010  Asistent, Ústav chemických léčiv, Farmaceutická fakulta VFU Brno
2005-2010  Vědecký pracovník, Katedra anorganické chemie, PřF UP v Olomouci
od 2010        Odborný asistent, Ústav chemických léčiv, Farmaceutická fakulta VFU Brno
od 2010      Junior Researcher, Regionální centrum pokročilých technologií a materiálů PřF UP v Olomouci

Oblast výzkumu:
Syntéza, strukturní a spektrální analýza nových bioaktivních komplexů Cu(II), Zn(II), Fe(III), Co(II/III), Ni(II), Mn(II) s ligandy typu Schiffových basí.
Studium chemické reaktivity a biologických aktivit se zaměřením na antiradikálovou, antimikrobní, antidiabetickou a cytotoxickou aktivitu.
Analytické hodnocení metabolitů oxidačního poškození biomolekul, vývoj metod stanovení s použitím HPLC-DAD/FLD, LC/MS.
Analytické hodnocení obsahových látek rostlinných drog a identifikace sekundárních metabolitů pomocí HPLC-DAD/FLD, LC/MS a ESI-MS spektroskopie.
Vývoj a validace metod analýzy léčiv v biologických vzorcích.

Publikační aktivita:
Počet publikací (WoS): 27
Počet citací (WoS): 121 (bez autocitací)
H-index: 6

Účast na konferencích:
Prezentace 46 příspěvků na domácích i zahraničních konferencích.

Další aktivity:
Granty:
Řešitel dvou grantů IGA VFU (2002, 2010)

Členství ve vědeckých společnostech:
American Chemical Society, The Society of Biological Inorganic Chemistry, Society for Free Radicals in Biology and Medicine, Society for Free Radical Research – Europe, Česká společnost chemická

Recenzní činnost pro časopisy s IF:
Bioorganic and Medicinal Chemistry, Diabetes Research and Clinical Practice, Journal of Coordination Chemistry, International Journal of Molecular Sciences

Vybrané publikace:

Buchtík R., Trávníček Z., Vančo J., Herchel R., Dvořák Z.: Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(ii) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)- quinolinone. Dalton Trans. 40(37), 9404-9412 (2011).
Trávníček Z., Matíková-Maľarová M., Novotná R., Vančo J., Štěpánková K., Suchý P. Jr.: In vitro and in vivo biological activity screening of Ru(III) complexes involving 6-benzylaminopurine derivatives with higher pro-apoptotic activity than NAMI-A. J. Inorg. Biochem. 105(7), 937-948 (2011).
Vančo J., Trávníček Z., Marek J., Herchel R.: Synthesis, spectral (UV/Vis, IR, ESI-MS), magnetic and structural characterizations, and antimicrobial effect of potassium isothiocyanato-(N-salicylideneamino-acidato)cuprates. Inorg. Chim. Acta 363(14), 3887-3896 (2010).
Herchel R., Šindelář Z., Trávníček Z., Zbořil R., Vančo J.: Novel 1D chain Fe(III)-salen-like complexes involving anionic heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic, 57Fe Mössbauer, and biological activity studies. Dalton Trans. (44), 9870-9880 (2009).
Štarha P., Trávníček Z., Herchel R., Popa I., Suchý P. ml., Vančo J.: Dinuclear copper(II) complexes containing 6-(benzylamino)purines as bridging ligands: Synthesis, characterization, and in vitro and in vivo antioxidant activities. J. Inorg. Biochem. 103, 432-440 (2009).

Ukázat publikace

Publikace

2011

Z. Travnicek, M. Matikova-Malarova, R. Novotna, J. Vanco, K. Stepankova, and P. Suchy, „In vitro and in vivo biological activity screening of Ru(III) complexes
involving 6-benzylaminopurine derivatives with higher pro-apoptotic
activity than NAMI-A,“ JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 105, iss. 7, pp. 937-948, 2011.
[Bibtex]

@article ISI:000291518700002,
Author = Travnicek, Zdenek and Matikova-Malarova, Miroslava and Novotna, Radka
   and Vanco, Jan and Stepankova, Kamila and Suchy, Pavel,
Title = In vitro and in vivo biological activity screening of Ru(III) complexes
   involving 6-benzylaminopurine derivatives with higher pro-apoptotic
   activity than NAMI-A,
Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
Year = 2011,
Volume = 105,
Number = 7,
Pages = 937-948,
Month = JUL,
DOI = 10.1016/j.jinorgbio.2011.04.002,
ISSN = 0162-0134,
Unique-ID = ISI:000291518700002,

R. Buchtik, Z. Travnicek, J. Vanco, R. Herchel, and Z. Dvorak, „Synthesis, characterization, DNA interaction and cleavage, and in vitro
cytotoxicity of copper(II) mixed-ligand complexes with
2-phenyl-3-hydroxy-4(1H)-quinolinone,“ DALTON TRANSACTIONS, vol. 40, iss. 37, pp. 9404-9412, 2011.
[Bibtex]

@article ISI:000294666700010,
Author = Buchtik, Roman and Travnicek, Zdenek and Vanco, Jan and Herchel, Radovan
   and Dvorak, Zdenek,
Title = Synthesis, characterization, DNA interaction and cleavage, and in vitro
   cytotoxicity of copper(II) mixed-ligand complexes with
   2-phenyl-3-hydroxy-4(1H)-quinolinone,
Journal = DALTON TRANSACTIONS,
Year = 2011,
Volume = 40,
Number = 37,
Pages = 9404-9412,
DOI = 10.1039/c1dt10674k,
ISSN = 1477-9226,
Unique-ID = ISI:000294666700010,

2010

J. Vanco, Z. Travnicek, J. Marek, and R. Herchel, „Synthesis, spectral (UV-Vis, IR, ESI-MS), magnetic and structural
characterizations, and the antimicrobial effect of potassium
isothiocyanato-(N-salicylidene-amino-acidato)cuprates,“ INORGANICA CHIMICA ACTA, vol. 363, iss. 14, pp. 3887-3896, 2010.
[Bibtex]

@article ISI:000283051600035,
Author = Vanco, Jan and Travnicek, Zdenek and Marek, Jaromir and Herchel, Radovan,
Title = Synthesis, spectral (UV-Vis, IR, ESI-MS), magnetic and structural
   characterizations, and the antimicrobial effect of potassium
   isothiocyanato-(N-salicylidene-amino-acidato)cuprates,
Journal = INORGANICA CHIMICA ACTA,
Year = 2010,
Volume = 363,
Number = 14,
Pages = 3887-3896,
Month = NOV 25,
DOI = 10.1016/j.ica.2010.07.041,
ISSN = 0020-1693,
Unique-ID = ISI:000283051600035,

A. Klanicova, Z. Travnicek, J. Vanco, I. Popa, and Z. Sindelar, „Dinuclear copper(II) perchlorate complexes with 6-(benzylamino)purine
derivatives: Synthesis, X-ray structure, magnetism and antiradical
activity,“ POLYHEDRON, vol. 29, iss. 13, pp. 2582-2589, 2010.
[Bibtex]

@article ISI:000282389900003,
Author = Klanicova, Alena and Travnicek, Zdenek and Vanco, Jan and Popa, Igor and
   Sindelar, Zdenek,
Title = Dinuclear copper(II) perchlorate complexes with 6-(benzylamino)purine
   derivatives: Synthesis, X-ray structure, magnetism and antiradical
   activity,
Journal = POLYHEDRON,
Year = 2010,
Volume = 29,
Number = 13,
Pages = 2582-2589,
Month = SEP 3,
DOI = 10.1016/j.poly.2010.06.007,
ISSN = 0277-5387,
Unique-ID = ISI:000282389900003,

P. Babula, J. Vanco, V. Kohoutkova, I. Dankova, L. Ohnoutkova, L. Havel, and R. Kizek, „Phytotoxicity of New Complex of Lawsone with Cu(II) Ions,“ IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, vol. 46, iss. S, pp. S148, 2010.
[Bibtex]

@article ISI:000285367500330,
Author = Babula, Petr and Vanco, Jan and Kohoutkova, Veronika and Dankova, Ivana
   and Ohnoutkova, Ludmila and Havel, Ladislav and Kizek, Rene,
Title = Phytotoxicity of New Complex of Lawsone with Cu(II) Ions,
Journal = IN VITRO CELLULAR \& DEVELOPMENTAL BIOLOGY-ANIMAL,
Year = 2010,
Volume = 46,
Number = S,
Pages = S148,
Month = SPR,
ISSN = 1071-2690,
Unique-ID = ISI:000285367500330,

2009

P. Starha, Z. Travnicek, R. Herchel, I. Popa, P. Suchy, and J. Vanco, „Dinuclear copper(II) complexes containing 6-(benzylamino)purines as
bridging ligands: Synthesis, characterization, and in vitro and in vivo
antioxidant activities,“ JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 103, iss. 3, pp. 432-440, 2009.
[Bibtex]

@article ISI:000263693900016,
Author = Starha, Pavel and Travnicek, Zdenek and Herchel, Radovan and Popa, Igor
   and Suchy, Pavel and Vanco, Jan,
Title = Dinuclear copper(II) complexes containing 6-(benzylamino)purines as
   bridging ligands: Synthesis, characterization, and in vitro and in vivo
   antioxidant activities,
Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
Year = 2009,
Volume = 103,
Number = 3,
Pages = 432-440,
Month = MAR,
DOI = 10.1016/j.jinorgbio.2008.12.009,
ISSN = 0162-0134,
Unique-ID = ISI:000263693900016,

R. Herchel, Z. Sindelar, Z. Travnicek, R. Zboril, and J. Vanco, „Novel 1D chain Fe(III)-salen-like complexes involving anionic
heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic,
(57)Fe Mossbauer, and biological activity studies,“ DALTON TRANSACTIONS, iss. 44, pp. 9870-9880, 2009.
[Bibtex]

@article ISI:000271432600028,
Author = Herchel, Radovan and Sindelar, Zdenek and Travnicek, Zdenek and Zboril,
   Radek and Vanco, Jan,
Title = Novel 1D chain Fe(III)-salen-like complexes involving anionic
   heterocyclic N-donor ligands. Synthesis, X-ray structure, magnetic,
   (57)Fe Mossbauer, and biological activity studies,
Journal = DALTON TRANSACTIONS,
Year = 2009,
Number = 44,
Pages = 9870-9880,
DOI = 10.1039/b912676g,
ISSN = 1477-9226,
Unique-ID = ISI:000271432600028,

2008

J. Vanco, J. Marek, Z. Travnicek, E. Racanska, J. Muselik, and O. Svajlenova, „Synthesis, structural characterization, antiradical and antidiabetic
activities of copper(II) and zinc(II) Schiff base complexes derived from
salicylaldehyde and beta-alanine,“ JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 102, iss. 4, pp. 595-605, 2008.
[Bibtex]

@article ISI:000255131500001,
Author = Vanco, Jan and Marek, Jaromir and Travnicek, Zdenek and Racanska, Eva
   and Muselik, Jan and Svajlenova, Ol'ga,
Title = Synthesis, structural characterization, antiradical and antidiabetic
   activities of copper(II) and zinc(II) Schiff base complexes derived from
   salicylaldehyde and beta-alanine,
Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
Year = 2008,
Volume = 102,
Number = 4,
Pages = 595-605,
Month = APR,
DOI = 10.1016/j.jinorgbio.2007.10.003,
ISSN = 0162-0134,
Unique-ID = ISI:000255131500001,

Z. Travnicek, J. Marek, J. Vanco, and O. Svajlenova, „Aqua(4-methylquinoline-kappa N)[N-(2-oxidobenzylidene)glycinato-kappa
O-3,N,O `]copper(II) hemihydrate,“ ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, vol. 64, iss. Part 2, pp. M282-U199, 2008.
[Bibtex]

@article ISI:000253779700023,
Author = Travnicek, Zdenek and Marek, Jaromir and Vanco, Jan and Svajlenova, Olga,
Title = Aqua(4-methylquinoline-kappa N)[N-(2-oxidobenzylidene)glycinato-kappa
   O-3,N,O `]copper(II) hemihydrate,
Journal = ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE,
Year = 2008,
Volume = 64,
Number = Part 2,
Pages = M282-U199,
Month = FEB,
DOI = 10.1107/S1600536807067852,
ISSN = 1600-5368,
Unique-ID = ISI:000253779700023,

2007

F. Sersen, D. Loos, J. Csollei, I. Popa, J. Vanco, and F. Gregan, „Antioxidative activity of potential antihypertensives with dual effect,“ CHEMICKE LISTY, vol. 101, iss. 1, pp. 60-64, 2007.
[Bibtex]

@article ISI:000243899600009,
Author = Sersen, Frantisek and Loos, Dusan and Csollei, Jozef and Popa, Igor and
   Vanco, Jan and Gregan, Fridrich,
Title = Antioxidative activity of potential antihypertensives with dual effect,
Journal = CHEMICKE LISTY,
Year = 2007,
Volume = 101,
Number = 1,
Pages = 60-64,
ISSN = 0009-2770,
Unique-ID = ISI:000243899600009,

PharmDr. Ján Vančo, Ph.D.

2011

2010

2009

2008

2007