Regionální centrum pokročilých technologií a materiálů

Email: pavel.starha@upol.cz
Adresa: 17. listopadu 12, Olomouc
Telefon: (+420) 58 563 4346
Fax: (+420) 58 563 4357

Vzdělání a kvalifikace:
Mgr. – 2001–2006        Učitelství biologie a chemie pro střední školy, Univerzita Palackého v Olomouci
Ph.D. – 2006–2010        Anorganická chemie, Univerzita Palackého v Olomouci
2006–2010        Vědecký pracovník, Katedra anorganické chemie PřF UP v Olomouci
od 2010    Odborný asistent, Katedra anorganické chemie PřF UP v Olomouci
od 2010 Junior Researcher, Regionální centrum pokročilých technologií a materiálů PřF UP v Olomouci

Oblast výzkumu:
Komplexy přechodných kovů (Pt, Pd, Cu atd.), Biologická (cytotoxická, antiradikálová atd.) aktivita komplexů přechodných kovů, Termická analýza (TG, DTA, DSC) a izotermální titrační kalorimetrie (ITC)

Publikační aktivita:
Počet publikací (WoS): 12
Počet citací (WoS): 45
H-index: 4

Zahraniční pobyty:
Březen-květen 2008 – studijní pobyt na Juniata College (PA, USA)

Další aktivity:
FRVŠ (1822/2011/F6) – Inovace výuky a příprava praktických úkolů předmětu Termická analýza

Vybrané publikace:

P. Štarha, Z. Trávníček, I. Popa, Oxalátokomplexy platiny s deriváty N6-benzyladeninu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protinádorové terapii, Univerzita Palackého v Olomouci, patentový spis CZ 302623 B6 (2011)
Z.Trávníček, P. Štarha, I. Popa, R. Vrzal, Z. Dvořák, Roscovitine-based CDK inhibitors acting as N‑donor ligands in the platinum(II) oxalato complexes: preparation, characterization and in vitro cytotoxicity, Eur. J. Med. Chem. 45 (2010) 4609–4614.
P. Štarha, Z. Trávníček, I. Popa, Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity, J. Inorg. Biochem. 104 (2010) 639–647.
P. Štarha, Z. Trávníček, I. Popa, Synthesis, characterization and in vitro cytotoxicity of the first palladium(II) oxalato complexes involving adenine‑based ligands, J. Inorg. Biochem. 103 (2009) 978–988.
P. Štarha, Z. Trávníček, R. Herchel, I. Popa, P. Suchý, J. Vančo, Dinuclear copper(II) complexes containing 6-(benzylamino)purines as bridging ligands: Synthesis, characterization, and in vitro and in vivo antioxidant activities, J. Inorg. Biochem. 103 (2009) 432–440.

Ukázat publikace

Publikace

2011

R. Pastorek, P. Starha, T. Peterek, and Z. Travnicek, „Nickel(IV) dithiocarbamato complexes of the [Ni(ndtc)(3)]X type: X-ray
structure of [Ni(hmidtc)(3)][FeCl4],“ POLYHEDRON, vol. 30, iss. 17, pp. 2795-2800, 2011.
[Bibtex]

@article ISI:000296996500006,
Author = Pastorek, Richard and Starha, Pavel and Peterek, Tomas and Travnicek,
   Zdenek,
Title = Nickel(IV) dithiocarbamato complexes of the [Ni(ndtc)(3)]X type: X-ray
   structure of [Ni(hmidtc)(3)][FeCl4],
Journal = POLYHEDRON,
Year = 2011,
Volume = 30,
Number = 17,
Pages = 2795-2800,
Month = NOV 3,
DOI = 10.1016/j.poly.2011.08.022,
ISSN = 0277-5387,
Unique-ID = ISI:000296996500006,

R. Pastorek, Z. Travnicek, and P. Starha, „Octahedral nickel(II) hexamethyleneimine-dithiocarbamato complexes
involving bidentate N,N-donor ligands,“ INORGANICA CHIMICA ACTA, vol. 373, iss. 1, pp. 286-290, 2011.
[Bibtex]

@article ISI:000291244600042,
Author = Pastorek, Richard and Travnicek, Zdenek and Starha, Pavel,
Title = Octahedral nickel(II) hexamethyleneimine-dithiocarbamato complexes
   involving bidentate N,N-donor ligands,
Journal = INORGANICA CHIMICA ACTA,
Year = 2011,
Volume = 373,
Number = 1,
Pages = 286-290,
Month = JUL 15,
DOI = 10.1016/j.ica.2011.03.010,
ISSN = 0020-1693,
Unique-ID = ISI:000291244600042,

Z. Dvorak, P. Starha, and Z. Travnicek, „Evaluation of in vitro cytotoxicity of 6-benzylaminopurine carboplatin
derivatives against human cancer cell lines and primary human
hepatocytes,“ TOXICOLOGY IN VITRO, vol. 25, iss. 3, pp. 652-656, 2011.
[Bibtex]

@article ISI:000288933100008,
Author = Dvorak, Zdenek and Starha, Pavel and Travnicek, Zdenek,
Title = Evaluation of in vitro cytotoxicity of 6-benzylaminopurine carboplatin
   derivatives against human cancer cell lines and primary human
   hepatocytes,
Journal = TOXICOLOGY IN VITRO,
Year = 2011,
Volume = 25,
Number = 3,
Pages = 652-656,
Month = APR,
DOI = 10.1016/j.tiv.2011.01.002,
ISSN = 0887-2333,
Unique-ID = ISI:000288933100008,

2010

Z. Travnicek, P. Starha, I. Popa, R. Vrzal, and Z. Dvorak, „Roscovitine-based CDK inhibitors acting as N-donor ligands in the
platinum(II) oxalato complexes: Preparation, characterization and in
vitro cytotoxicity,“ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, iss. 10, pp. 4609-4614, 2010.
[Bibtex]

@article ISI:000282112700024,
Author = Travnicek, Zdenek and Starha, Pavel and Popa, Igor and Vrzal, Radim and
   Dvorak, Zdenek,
Title = Roscovitine-based CDK inhibitors acting as N-donor ligands in the
   platinum(II) oxalato complexes: Preparation, characterization and in
   vitro cytotoxicity,
Journal = EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,
Year = 2010,
Volume = 45,
Number = 10,
Pages = 4609-4614,
Month = OCT,
DOI = 10.1016/j.ejmech.2010.07.025,
ISSN = 0223-5234,
Unique-ID = ISI:000282112700024,

R. Vrzal, P. Starha, Z. Dvorak, and Z. Travnicek, „Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II)
and palladium(II) oxalato complexes with adenine derivatives as carrier
ligands,“ JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 104, iss. 10, pp. 1130-1132, 2010.
[Bibtex]

@article ISI:000281525200017,
Author = Vrzal, Radim and Starha, Pavel and Dvorak, Zdenek and Travnicek, Zdenek,
Title = Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II)
   and palladium(II) oxalato complexes with adenine derivatives as carrier
   ligands,
Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
Year = 2010,
Volume = 104,
Number = 10,
Pages = 1130-1132,
Month = OCT,
DOI = 10.1016/j.jinorgbio.2010.07.002,
ISSN = 0162-0134,
Unique-ID = ISI:000281525200017,

L. Dvorak, I. Popa, P. Starha, and Z. Travnicek, „In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from
Carboplatin and Involving Purine Derivatives,“ EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, iss. 22, pp. 3441-3448, 2010.
[Bibtex]

@article ISI:000281061700006,
Author = Dvorak, Lukas and Popa, Igor and Starha, Pavel and Travnicek, Zdenek,
Title = In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from
   Carboplatin and Involving Purine Derivatives,
Journal = EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,
Year = 2010,
Number = 22,
Pages = 3441-3448,
Month = AUG,
DOI = 10.1002/ejic.201000322,
ISSN = 1434-1948,
Unique-ID = ISI:000281061700006,

P. Starha, R. Novotna, and Z. Travnicek, „X-ray structure and properties of a dinuclear palladium(II) complex
[Pd(2)(mu-L)(4)] with four adenine-based bridges in a paddle
wheel-like arrangement,“ INORGANIC CHEMISTRY COMMUNICATIONS, vol. 13, iss. 6, pp. 800-803, 2010.
[Bibtex]

@article ISI:000279136700029,
Author = Starha, Pavel and Novotna, Radka and Travnicek, Zdenek,
Title = X-ray structure and properties of a dinuclear palladium(II) complex
   [Pd(2)(mu-L)(4)] with four adenine-based bridges in a paddle
   wheel-like arrangement,
Journal = INORGANIC CHEMISTRY COMMUNICATIONS,
Year = 2010,
Volume = 13,
Number = 6,
Pages = 800-803,
Month = JUN,
DOI = 10.1016/j.inoche.2010.04.001,
ISSN = 1387-7003,
Unique-ID = ISI:000279136700029,

P. Starha, Z. Travnicek, and I. Popa, „Platinum(II) oxalato complexes with adenine-based carrier ligands
showing significant in vitro antitumor activity,“ JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 104, iss. 6, pp. 639-647, 2010.
[Bibtex]

@article ISI:000277946300004,
Author = Starha, Pavel and Travnicek, Zdenek and Popa, Igor,
Title = Platinum(II) oxalato complexes with adenine-based carrier ligands
   showing significant in vitro antitumor activity,
Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
Year = 2010,
Volume = 104,
Number = 6,
Pages = 639-647,
Month = JUN,
DOI = 10.1016/j.jinorgbio.2010.02.005,
ISSN = 0162-0134,
Unique-ID = ISI:000277946300004,

P. Starha, I. Popa, and Z. Travnicek, „Palladium(II) oxalato complexes involving
N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis,
general properties, (1)H, (13)C and (15)N\(1)H\ NMR characterization
and in vitro cytotoxicity,“ INORGANICA CHIMICA ACTA, vol. 363, iss. 7, pp. 1469-1478, 2010.
[Bibtex]

@article ISI:000276190300021,
Author = Starha, Pavel and Popa, Igor and Travnicek, Zdenek,
Title = Palladium(II) oxalato complexes involving
   N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis,
   general properties, (1)H, (13)C and (15)N\(1)H\ NMR characterization
   and in vitro cytotoxicity,
Journal = INORGANICA CHIMICA ACTA,
Year = 2010,
Volume = 363,
Number = 7,
Pages = 1469-1478,
Month = APR 20,
DOI = 10.1016/j.ica.2010.01.035,
ISSN = 0020-1693,
Unique-ID = ISI:000276190300021,

Z. Dvorak, R. Vrzal, P. Starha, A. Klanicova, and Z. Travnicek, „Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine
derivatives on AhR and PXR dependent expression of cytochromes P450
CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes,“ TOXICOLOGY IN VITRO, vol. 24, iss. 2, pp. 425-429, 2010.
[Bibtex]

@article ISI:000275991700011,
Author = Dvorak, Zdenek and Vrzal, Radim and Starha, Pavel and Klanicova, Alena
   and Travnicek, Zdenek,
Title = Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine
   derivatives on AhR and PXR dependent expression of cytochromes P450
   CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes,
Journal = TOXICOLOGY IN VITRO,
Year = 2010,
Volume = 24,
Number = 2,
Pages = 425-429,
Month = MAR,
DOI = 10.1016/j.tiv.2009.10.012,
ISSN = 0887-2333,
Unique-ID = ISI:000275991700011,

Z. Travnicek, R. Pastorek, P. Starha, I. Popa, and V. Slovak, „Nickel(II) N-Benzyl-N-methyldithiocarbamato Complexes as Precursors for
the Preparation of Graphite Oxidation Accelerators,“ ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, vol. 636, iss. 8, pp. 1557-1564, 2010.
[Bibtex]

@article ISI:000280659500023,
Author = Travnicek, Zdenek and Pastorek, Richard and Starha, Pavel and Popa, Igor
   and Slovak, Vaclav,
Title = Nickel(II) N-Benzyl-N-methyldithiocarbamato Complexes as Precursors for
   the Preparation of Graphite Oxidation Accelerators,
Journal = ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE,
Year = 2010,
Volume = 636,
Number = 8,
Pages = 1557-1564,
DOI = 10.1002/zaac.201000091,
ISSN = 0044-2313,
Unique-ID = ISI:000280659500023,

2009

P. Starha, Z. Travnicek, and I. Popa, „Synthesis, characterization and in vitro cytotoxicity of the first
palladium(II) oxalato complexes involving adenine-based ligands,“ JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 103, iss. 7, pp. 978-988, 2009.
[Bibtex]

@article ISI:000267768200006,
Author = Starha, Pavel and Travnicek, Zdenek and Popa, Igor,
Title = Synthesis, characterization and in vitro cytotoxicity of the first
   palladium(II) oxalato complexes involving adenine-based ligands,
Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
Year = 2009,
Volume = 103,
Number = 7,
Pages = 978-988,
Month = JUL,
DOI = 10.1016/j.jinorgbio.2009.04.008,
ISSN = 0162-0134,
Unique-ID = ISI:000267768200006,

P. Starha, Z. Travnicek, R. Herchel, I. Popa, P. Suchy, and J. Vanco, „Dinuclear copper(II) complexes containing 6-(benzylamino)purines as
bridging ligands: Synthesis, characterization, and in vitro and in vivo
antioxidant activities,“ JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 103, iss. 3, pp. 432-440, 2009.
[Bibtex]

@article ISI:000263693900016,
Author = Starha, Pavel and Travnicek, Zdenek and Herchel, Radovan and Popa, Igor
   and Suchy, Pavel and Vanco, Jan,
Title = Dinuclear copper(II) complexes containing 6-(benzylamino)purines as
   bridging ligands: Synthesis, characterization, and in vitro and in vivo
   antioxidant activities,
Journal = JOURNAL OF INORGANIC BIOCHEMISTRY,
Year = 2009,
Volume = 103,
Number = 3,
Pages = 432-440,
Month = MAR,
DOI = 10.1016/j.jinorgbio.2008.12.009,
ISSN = 0162-0134,
Unique-ID = ISI:000263693900016,

Mgr. Pavel Štarha, Ph.D.

2011

2010

2009