Biologically-active complexes and molecular magnets

Scientific News In Biologically-active Complexes and Molecular Magnets

Head of the Division:

Prof. RNDr. Zdeněk Trávníček, Ph.D.

Scientific focus of the division:

  • Development of the new types of biologically active coordination compounds of the selected transition metals with high application potential in medicine and pharmacology (e.g. substances with antitumour, anti-inflammatory or antidiabetic activity).
  • Preparation and study of molecular magnets and molecular switches based on the transition metal complexes applicable as sensors or high density memory or recording media, etc.
  • Study of hybrid molecular-crystalline nanostructures with functionalized nanocrystalline iron oxide-based carriers with bound biologically active compound for the purpose of using these systems in targeted drug delivery or with magnetically interesting compound.

Results highlights – Patents:

Platinum diiodo complexes with ω-substituted derivatives of 6-alkyloxy-9-deazapurine and use of these complexes for the preparation of medicaments for antitumor therapy (CZ 306966 B6, 09/2017). Applicant: Palacký University in Olomouc. Inventors: Trávníček, Z.; Vančo, J.; Gáliková, J.; Křikavová, R., Dvořák, Z.

Utilization of copper complexes involving 2-phenyl-3-hydroxy-4(1H)-quinolinone and 1,10-phenanthroline derivatives for the preparation of drugs for the treatment of tumour diseases (EP2650000 B1, 02/2017). Applicant: Palacký University in Olomouc. Inventors: Trávníček, Z.; Vančo, J.; Buchtík, R.; Dvořák, Z.

Gold complexes with ω-substituted derivatives of 6-alkyloxy-9-deazapurines and phosphane derivatives and use of these complexes for the preparation of drugs for the therapy of inflammatory and tumour diseases (CZ 305624 B6, 12/2015). Applicant: Palacký University in Olomouc. Inventors: Trávníček, Z.; Gáliková, J.; Hošek, J.; Vančo, J.

Gold complexes with hypoxanthine derivatives and phosphane derivatives and their use for preparation of drugs in anti-inflammatory and antitumour therapy (CZ 305585 B6, 11/2015). Applicant: Palacký University in Olomouc. Inventors: Trávníček, Z.; Křikavová, R.; Hošek, J.; Dvořák, Z.

Dichlorido complexes of platinum with kinetin derivatives, method of their preparation and use of these complexes as drugs in anticancer treatment (CZ 305411 B6, 08/2015). Applicant: Palacký University in Olomouc. Inventors: Trávníček, Z.; Novotná, R.; Dvořák, Z.

Platinum dijodido-complexes and their use for preparation of drugs for the treatment of tumour diseases (CZ 305374 B6, 07/2015). Applicant: Palacký University in Olomouc. Inventors: Z. Trávníček, P. Štarha, Z. Dvořák.

Dichlorido complexes of platinum with 7-azaindole halogeno-derivatives for use in the treatment of tumour diseases (EP2636410 B1, 04/2015). Applicant: Palacky University in Olomouc. Inventors: Trávníček, Z.; Štarha, P.; Dvořák, Z.

Salophen complexes of iron with heterocyclic N-donor ligands, method of their preparation and use as drugs in anticancer treatment (CZ 304883 B6, 11/2014). Applicant: Palacký University in Olomouc. Inventors: Trávníček, Z.; Šindelář, Z.; Dvořák, Z.

Použití komplexů mědi obsahujících 2-fenyl-3-hydroxychinolin-4(1H)-on a deriváty 1,10-fenanthrolinu pro přípravu léčiv pro léčbu nádorových onemocnění (CZ 304045 B6, 07/2013). Majitel: Univerzita Palackého v Olomouci. Původce: Z. Trávníček, J. Vančo, R. Buchtík, Z. Dvořák.

Komplexy zlata s deriváty N6-benzyladeninu a deriváty fosfanu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protizánětlivé terapii (CZ 303649 B6; 12/2012). Majitel: Univerzita Palackého v Olomouci. Původce: Z. Trávníček, J. Vančo, I. Popa, T. Šilha.

The use of platinum dichlorido complexes involving halogeno derivatives of 7-azaindole for the preparation of drugs for the treatment of cancer (CZ 303560 B6, 10/2012). Applicant: Palacky University in Olomouc. Inventors: Z. Trávníček, P. Štarha, Z. Dvořák.

Buchtík, R.; Dvořák, Z.; Trávníček, Z.; Vančo. J. Komplexy mědi s deriváty 2-fenyl-3-hydroxychinolin-4(1H)-onu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protinádorové terapii. (CZ 303009 B6, udělen 11.1.2012)

Štarha, P.; Trávníček, Z.; Popa, I. Oxalátokomplexy platiny s deriváty N6-benzyladeninu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protinádorové terapii (CZ 302623 B6, udělen 23.6.2011) Dvořák, L.; Trávníček, Z.; Popa, I. Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protinádorové terapii (CZ 302618 B6, udělen 23.6.2011)

Results highlights – Publications:

plosone-default

Vančo, J.; Trávníček, Z.; Hošek, J.; Suchý, P. Jr. In vitro and in vivo anti-inflammatory active copper(II)-lawsone complexes. PLoS ONE 2017, 12, e0181822. Link


Vančo, J.; Trávníček, Z.; Křikavová, R.; Gáliková, J.; Chalupová, M. Molecular, cellular and pharmacological effects of platinum(II) diiodido complexes containing 9-deazahypoxanthine derivatives: A group of broad-spectrum anticancer active agents. Journal of Photochemistry and Photobiology B: Biology 2017, 173, 423–433. Link


Drahoš, B.; Herchel, R.; Trávníček, Z. Impact of Halogenido Coligands on Magnetic Anisotropy in Seven-Coordinate Co(II) Complexes. Inorganic Chemistry 2017, 56, 5076-5088. Link

 


sc_008Gusev, A.; Herchel, R.; Nemec, I.; Shulgin, V.; Eremenko, I. L.; Lyssenko, K.; Linert, W.; Trávníček, Z. Tetranuclear lanthanide complexes containing a hydrazone-type ligand. Dysprosium [2 × 2] gridlike single-molecule magnet and toroic. Inorg. Chem. 55 (2016) 12470-12476. Link


plosone-defaultŠtarha, P.; Vančo, J.; Trávníček, Z.; Hošek, J.; Klusáková, J.; Dvořák, Z. Platinum(II) iodido complexes of 7-azaindoles with significant antiproliferative effects: an old story revisited with unexpected outcomes. PLoS ONE 11 (2016) e0165062. Link

sc_004Herchel, R.; Nemec, I.; Machata, M.; Trávníček, Z. Solvent-induced structural diversity in tetranuclear Ni(II) Schiff-base complexes: the first Ni4 single-molecule magnet with a defective dicubane-like topology. Dalton Transactions 45 (2016) 18622-18634. Link

Antal, P.; Drahoš, B.; Herchel, R.; Trávníček, Z. Muffin-like lanthanide complexes with an N5O2-donor macrocyclic ligand showing field-induced single-molecule magnet behaviour. Dalton Transations, 2016, 45, 15114-15121. Link


Nemec, I.; Herchel, R.; Travnicek, Z. Ferromagnetic coupling mediated by Co∙∙∙π non-covalent contacts in a pentacoordinate Co(II) compound showing field-induced slow relaxation of magnetization. Dalton Transactions  2016, 45, 12479-12482. Link


Machalová Šišková, K.; Jančula, D,; Drahoš, B.; Machala, L.; Babica, P.; Godoy Alonso, P.; Trávníček, Z.; Tuček, J.; Maršálek, B.; Sharma, V.K.; Zbořil, R. High-valent iron (FeVI, FeV, and FeIV) species in water: characterization and oxidative transformation of estrogenic hormones. Physical Chemistry Chemical Physics, 2016, 18, 18802-18810. Link

Kubešová, K.; Trávníček, Z.; Dvořák, Z. Pleiotropic effects of gold(I) mixed-ligand complexes of 9-deazahypoxanthine on transcriptional activity of receptors for steroid hormones, nuclear receptors and xenoreceptors in human hepatocytes and cell lines. European Journal of Medicinal Chemistry, 2016, 121, 530-540. Link

image3Antal, P.; Drahoš, B.; Herchel, R.; Trávníček, Z. Late First-Row Transition-Metal Complexes Containing a 2-Pyridylmethyl Pendant-Armed 15-Membered Macrocyclic Ligand. Field-Induced Slow Magnetic Relaxation in a Seven-Coordinate Cobalt(II) Compound. Inorganic Chemistry, 2016, 55, 5957-5972. Link



Rathi, A.K.; Gawande, M.K.; Pechoušek, J.; Tuček, J.; Aparicio, C.; Petr, M.; Tomanec, O.; Křikavová, R.; Trávníček, Z.; Varma, R.S.; Zbořil, R. Maghemite decorated with ultra-small palladium nanoparticles (γ-Fe2O3–Pd): applications in the Heck–Mizoroki olefination, Suzuki reaction and allylic oxidation of alkenes. Green Chemistry 18 (2016) 2363-2373. Link


SC_009Štarha, P.; Habtemariam, A.; Romero-Canelón, I.; Clarkson, G. J.; Sadler, P. J. Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes. Inorganic Chemistry 55 (2016) 2324–2331. Link


SC_002
Štarha, P.; Hanousková, L.; Trávníček, Z. Organometallic half-sandwich dichloridoruthenium(II) complexes with 7-azaindoles: synthesis, characterization and elucidation of their anticancer inactivity against A2780 cell line. PLoS ONE 10 (2015) e0143871. Link



Kašpárková, J.; Kostrhunová, H.; Nováková, O.; Křikavová, R.; Vančo, J.; Trávníček, Z.; Brabec, V. A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases. Angewandte Chemie International Edition 54 (2015) 14478-14482. Link


SC_010
Štarha, P.; Dvořák, Z.; Trávníček, Z. Highly and Broad-Spectrum In Vitro Antitumor Active cis-Dichloridoplatinum(II) Complexes with 7-Azaindoles. PLoS ONE 10 (2015) e0136338. Link


SC_011
Nemec, I.; Marx, R.; Herchel, R.; Neugebauer, P.; van Slagerenb, J.; Trávníček, Z. Field-induced slow relaxation of magnetization in a pentacoordinate Co(II) compound [Co(phen)(DMSO)Cl2]. Dalton Transactions 44 (2015) 15014-15021. Link


SC_012
Herchel, R.; Nemec, I.; Machata, M.; Trávníček, Z. Experimental and Theoretical Investigations of Magnetic Exchange Pathways in Structurally Diverse Iron(III) Schiff-Base Complexes. Inorganic Chemistry 54 (2015) 8625-8638. Link



Nemec, I.; Herchel, R.; Trávníček, Z. Suppressing of slow magnetic relaxation in tetracoordinate Co(II) field-induced single-molecule magnet in hybrid material with ferromagnetic barium ferrite. Scientific Reports 5 (2015) 10761. Link



Nemec, I.; Herchel, R.; Svoboda, I.; Boča, R.; Trávníček, Z. Large and negative magnetic anisotropy in pentacoordinate mononuclear Ni(II) Schiff base complexes. Dalton Transactions 44 (2015) 9551-9560. Link


SC_000
Štarha, P.; Trávníček, Z.; Dvořák, Z.; Radošová-Muchová, T.; Prachařová, J.; Vančo, J.; Kašpárková, J. Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles. PLoS ONE 10 (2015) e0123595. Link


SC_000
Drahoš, B.; Herchel, R.; Trávníček, Z. Structural, Magnetic, and Redox Diversity of First-Row Transition Metal Complexes of a Pyridine-Based Macrocycle: Well-Marked Trends Supported by Theoretical DFT Calculations. Inorganic Chemistry 54 (2015) 3352-3369. Link



Nemec, I.; Herchel, R.; Trávníček, Z. The relationship between the strength of hydrogen bonding and spin crossover behaviour in a series of iron(III) Schiff base complexes. Dalton Transactions 44 (2015) 4474-4484. Link



Vančo, J.; Gáliková, J.; Hošek, J.; Dvořák, Z.; Paráková, L.; Trávníček, Z. Gold(I) Complexes of 9-Deazahypoxanthine as Selective Antitumor and Anti-Inflammatory Agents. PLoS ONE 9 (2014) e109901. Link



Nemec, I.; Herchel, R.; Šilha, T.; Trávníček, Z. Towards a better understanding of magnetic exchange mediated by hydrogen bonds in Mn(III)/Fe(III) salen-type supramolecular dimers. Dalton Transactions 43 (2014) 15602-15616. Link



Křikavová, R.; Hošek, J.; Vančo, J.; Hutyra, J.; Dvořák, Z.; Trávníček, Z. Gold(I)-Triphenylphosphine Complexes with Hypoxanthine-Derived Ligands: In Vitro Evaluations of Anticancer and Anti-Inflammatory Activities. PLoS ONE 9 (2014) e107373. Link


SC_008
Herchel, R.; Váhovská, L.; Potočňák, I.; Trávníček, Z. Slow Magnetic Relaxation in Octahedral Cobalt(II) Field-Induced Single-Ion Magnet with Positive Axial and Large Rhombic Anisotropy. Inorganic Chemistry 53 (2014) 5896-5898. Link



Štarha, P.; Hošek, J.; Vančo, J.; Dvořák, Z.; Suchý Jr., P.; Popa, I.; Pražanová, G.; Trávníček, Z. Pharmacological and Molecular Effects of Platinum(II) Complexes Involving 7-Azaindole Derivatives. PLoS ONE 9 (2014) e90341. Link



Herchel, R.; Trávníček, Z. 5-Aminotetrazole induces spin crossover in iron(III) pentadentate Schiff base complexes: experimental and theoretical investigations. Dalton Transactions 42 (2013) 16233–16438. Link


SC_009
Šilha T.; Nemec I.; Herchel R.; Trávníček Z. Structural and magnetic characterizations of the first manganese(III) Schiff base complexes involving hexathiocyanidoplatinate(IV) bridges. CrystEngComm 15 (2013) 5351-5358. Link



Trávníček, Z.; Štarha, P.;Vančo, J.; Šilha, T.; Hošek, J.; Suchý, P.; Pražanová, G. Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives. Journal of Medicinal Chemistry 55 (2012) 4568-4579. Link



Nemec, I.; Herchel, R.; Šalitroš, I.; Trávníček, Z.; Moncoľ, J.; Fuess, H.; Ruben, M.; Linert, W. Anion driven modulation of magnetic intermolecular interactions and spin crossover properties in an isomorphous series of mononuclear iron(iii) complexes with a hexadentate Schiff base ligand. CrystEngComm 14 (2012) 7015-7024. Link

Magneto-structural correlation describing the relationship between trigonality of coordination polyhedron and axial magnetic anisotropy parameter in pentacoordinated Ni(II) compounds

Highly anticancer active cis-diiodidoplatinum(II) complex with 4-brom-7-azaindole and its in vitro cytotoxicity against human cancer cell lines of breast carcinoma (MCF7), osteosarcoma (HOS), cervix carcinoma (HeLa), cisplatin sensitive (A2780) and resistant (A2780R) ovarian carcinomu and prostate carcinoma (22Rv1) as compared with clinically used platinum-based chemotherapeutic cisplatin.