10/29/2012
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Biologically-active complexes and molecular magnets
Another national patent granted
The members of RCPTM research division Biologically active complexes and molecular magnets Z. Trávníček, J. Vančo, I. Popa and T. Šilha are inventors of the national patent „Gold complexes with N6-benzyladenine and phosphane derivatives, method of their preparation and application of these complexes as drugs in anti-inflammatory treatment“ (CZ 303649; granted 18/12/2012). The subject matter of patent protection is the preparation and possible applicability of the gold(I) triphenylphosphino complexes with N6-benzyladenine derivatives as drugs for the treatment of inflammatory diseases.
The fifth national patent granted
The members of RCPTM research division Biologically active complexes and molecular magnets, led by prof. RNDr. Zdeněk Trávníček, Ph.D. participated, as inventors, in another national patent granted to Palacký University. “The use of Pt(II) dichlorido complexes of 7-azaindole derivatives in antitumour therapy” (CZ 303560 B6, inventors: Zdeněk Trávníček, Pavel Štarha, Zdeněk Dvořák; granted 24.10.2012).
Research iron complexes exhibiting spin crossover
Výsledky výzkumu komplexů železa vykazujících jev spinového křížení (angl. „spin crossover“) byly publikovány v časopise CrystEngComm (IF2011 = 3.84, Link). Publikace popisuje přípravu, strukturní a magnetickou charakterizaci izomorfní série látek, které se mezi sebou liší pouze halogenidovým aniontem. Touto studií byl prokázán vliv mezimolekulových interakcí (laděných záměnou aniontu) na magnetické vlastnosti látek při nízkých teplotách a také na jev spinového křížení, který byl pozorován nad pokojovou teplotou v tuhé fázi a při nízkých teplotách v roztoku.
Progress in the research of highly effective potential drugs with an anti-inflammatory effect
The scientists from the research division of RCPTM “Biologically active complexes and molecular magnets” lead by Prof. Trávníček have made significant progress in the research of novel highly effective potential drugs with an anti-inflammatory effect. The results of this research have been published in a prestigious journal of American Chemical Society Journal of Medicinal Chemistry (IF2010 = 5.207). http://pubs.acs.org/doi/abs/10.1021/jm201416p
Scientific News In Biologically-active Complexes and Molecular Magnets
Head of the Division: Prof. Zdeněk Trávníček, Ph.D.
Scientific focus of the division:
- Development of the new types of biologically active coordination compounds of the selected transition metals with high application potential in medicine and pharmacology (e.g. substances with antitumour, anti-inflammatory or antidiabetic activity).
- Preparation and study of molecular magnets and molecular switches based on the transition metal complexes applicable as sensors or high density memory or recording media, etc.
- Study of hybrid molecular-crystalline nanostructures with functionalized nanocrystalline iron oxide-based carriers with bound biologically active compound for the purpose of using these systems in targeted drug delivery or with magnetically interesting compound.
Results highlights – Patents:
Komplexy zlata s deriváty N6-benzyladeninu a deriváty fosfanu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protizánětlivé terapii (CZ 303649 B6; 12/2012). Majitel: Univerzita Palackého v Olomouci. Původce: Z. Trávníček, J. Vančo, I. Popa, T. Šilha.
The use of platinum dichlorido complexes involving halogeno derivatives of 7-azaindole for the preparation of drugs for the treatment of cancer (CZ 303560 B6, 10/2012). Applicant: Palacky University in Olomouc. Inventors: Z. Trávníček, P. Štarha, Z. Dvořák.
Buchtík, R.; Dvořák, Z.; Trávníček, Z.; Vančo. J. Komplexy mědi s deriváty 2-fenyl-3-hydroxychinolin-4(1H)-onu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protinádorové terapii. (CZ 303009 B6, udělen 11.1.2012)
Štarha, P.; Trávníček, Z.; Popa, I. Oxalátokomplexy platiny s deriváty N6-benzyladeninu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protinádorové terapii (CZ 302623 B6, udělen 23.6.2011) Dvořák, L.; Trávníček, Z.; Popa, I. Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, způsob jejich přípravy a použití těchto komplexů jako léčiv v protinádorové terapii (CZ 302618 B6, udělen 23.6.2011)
Results highlights – Publications:
Trávníček, Z.; Zbořil R.; Matiková-Maľarová, M.; Drahoš, B.; Černák, J. Thermal decomposition of [Co(en)3][Fe(CN)6]∙2H2O: Topotactic dehydration process, valence and spin exchange mechanism elucidation, Chem. Centr. J. 2013, 7, 28. Link
Trávníček, Z.; Vančo, J.; Hošek, J.; Buchtík, R.; Dvořák, Z. Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells, Chem. Cent. J. 2012, 6, 160-171. Link
Nemec, I.; Machata, M.; Herchel, R.; Boča, R.; Trávníček, Z. A new family of Fe2Ln complexes built from mononuclear anionic Schiff base subunits, Dalton Trans. 2012, 41, 14603-14610.Link
Trávníček, Z.; Štarha, P.; Vančo, J.; Šilha, T.; Hošek, J.; Suchý Jr., P. and Pražanová, G. Anti-inflammatory active gold(I) complexes involving 6 substituted-purine derivatives, J. Med. Chem. 2012, 55, 4568–4579.Link
Nemec, I.; Herchel, R.; Salitros, I.; Travnicek, Z.; Moncol, J.; Fuess, H.; Ruben, M. and Linert, W. Anion driven modulation of magnetic intermolecular interactions and spin crossover properties in an isomorphous series of mononuclear iron(III) complexes with a hexadentate Schiff base ligand. CrystEngComm. 2012, 14, 7015–7024.Link
Liskova, B.; Zerzankova, L.; Novakova, O.; Kostrhunova, H.; Travnicek, Z. and Brabec, V. Cellular Response to Antitumorcis-Dichlorido Platinum(II) Complexes of CDK Inhibitor Bohemine and Its Analogues, Chem. Res. Toxicol., 2012, 25, 500–509.Link
Herchel, R.; Travnicek, Z. and Zboril, R. Tuning of the Critical Temperature in Iron(II) Spin-Crossover Materials Based on Bridging Polycyanidometallates: Pentacyanidonitrosylferrate(II) and Hexacyanidoplatinate(IV), < em>Inorg. Chem. 2011, 50, 12390–12392. Link
Nemec, I.; Herchel, R.; Boča, R.; Trávníček, Z.; Svoboda, I.; Fuess H. and Linert, W. Tuning of spin crossover behaviour in iron(III) complexes involving pentadentate Schiff bases and pseudohalides, Dalton Trans., 2011, 40, 10090–10099. Link 
Buchtik, R.; Travnicek, Z.; Vanco, J.; Herchel, R. and Dvorak, Z. Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone, Dalton Trans., 2011, 40, 9404–9412.Link 
Herchel, R.; Tucek, J.; Travnicek, Z.; Petridis, D. and Zboril, R. Crystal Water Molecules as Magnetic Tuners in Molecular Metamagnets Exhibiting Antiferro-Ferro-Paramagnetic Transitions, Inorg. Chem. 2011, 50, 9153–9163.Link 
Trávníček, Z.; Štarha, P.; Popa I.; Vrzal, R.; Dvořák, Z. Roscovitine-Based CDK Inhibitors Acting as N-Donor Ligands in the Platinum(II) Oxalato Complexes: Preparation, Characterization and In Vitro Cytotoxicity, Eur. J. Med. Chem., 2010, 45, 4609-4614.Link 
Herchel, R.; Šindelář, Z.; Trávníček, Z.; Zbořil, R.; Vančo, J. Novel 1D Chain Fe(III)-salen-like Complexes Involving Anionic Heterocyclic N-Donor Ligands. Synthesis, X-ray Structure, Magnetic, 57Fe Mössbauer, and Biological Activity Studies, Dalton Trans. 2009, 9870-9880. Link 
Štarha, P.; Trávníček, Z.; Popa I. Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity, J. Inorg. Biochem. 2010, 104, 639–647.Link 
Single-crystal X-ray diffractometer (Xcalibur2)
400 MHz NMR spectrometer
Molecular structure of the highly in vitro antitumour active platinum(II) complex and comparison of its activities with commercially used platinum-based anticancer drug cisplatin against seven human cancer cell lines
Members of the division:
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