Nanotechnology in analytical chemistry
The Czech Science Foundation supports project “Characterization of nanoparticles by capillary electrophoresis”
Three-year research project with Jan Petr from RCPTM as the P.I. is supported by the Czech Science Foundation. The main aim of the project starting in 2016 is advanced description of electrophoretic behavior of nanoparticles, characterization of their surface chemistry and their interactions with small as well as large (corona-forming) molecules.
L. Hárendarčíková, D. Baron, A. Šebestová, J. Rozsypal, J. Petr: True lab-in-a-syringe technology for bioassays. Talanta 174 (2017) 285-288. Link
Authors from the Department of Analytical Chemistry, RCPTM, presented in their new article in the Talanta journal a unique approach for low-cost analysis called the true lab-in-a-syringe assay. Authors describe here a concept where the conjugation and reaction parts of the test are directly inserted in a syringe barrel. Then the movement of the plunger is the force for very fast and accurate analysis. Authors proved the concept on the determination of Ni(II) ions.
A method of measuring rapid changes of low values of surface conductivity of dielectrics in the environment of electromagnetic interference of mains voltage and a device for performing this method of measuring
On May 24, 2017, The Industrial Property Office of the Czech Republic published in the IPO Bulletin granting of a patent “A method of measuring rapid changes of low values of surface conductivity of dielectrics in the environment of electromagnetic …
Liquid chromatography/high resolution tandem mass spectrometry – Tool for the study of polyphenol profile changes during micro-scale biogas digestion of grape marcs
Lukáš Kučera, Ondřej Kurka, Petr Barták, Petr Bednář Link
CHEMOSPHERE, Volume: 166 Pages: 463-472 Published: 2017
The article is dealing with anaerobic fermentation of wine waste an biogas production. Important part of this article is study of fate of polyphenols.
Daniel Riman, Konstantinos Spyrou, Alexandros E. Karantzalis, Jan Hrbac, Mamas I.
TALANTA, Volume: 165 Pages: 466-473 Published 2017
The article discusses the modification of screen-printed graphite electrodes with copper nickel alloy by spark discharge used as non-enzymatic glucose sensor.
Department of Analytical Chemistry, FS UP and Archaeological Centre in Olomouc signed a framework contract related to cooperation in the area of the study of archaeological findings. Department of Analytical Chemistry will deal with chemical analysis of those findings. The …
Czech Science Foundation project – New Approaches for Monitoring of Transport of Selected Xenobiotics across Biomimetic Membranes
GA ČR (17-05387S) Co-investigator: RNDr. Jana Skopalová, Ph.D. 2017-2019, 110 thousand EUR The project is aimed at development and application of new approaches for monitoring of transport of selected xenobiotics and other biologically important compounds (e.g., drugs, hazardous elements, their …
Czech Science Foundation project – Advanced chemical analysis of residues of organic materials in archaeological context
GAČR 17-17346S Investigator: Assoc. Prof. RNDr. Petr Bednář, Ph.D. 2017- 2019, 4,1 mil. CZK Project is focused on the development of procedures for systematic analysis of organic residues in archaeological findings using top technologies and interpretation of obtained data in …
By: Jakub Přichystal, Kevin A. Schug, Karel Lemr, Jiří Novák, Vladimír Havlíček Link
ANALYTICAL CHEMISTRY, Volume: 88 Issue: 21 Pages: 10338–10346 Published 2016
This invited Feature article in prestigious Analytical Chemistry reports on recent developments in structural analysis of natural products that represent important sources of new pharmaceuticals. The article is focused to three methods – mass spectrometry, nuclear magnetic resonance spectroscopy, and X-ray diffraction. American Chemical Society promoted the article graphics on journal cover page of November issue.
Partnership between RCPTM and Waters signed for next three years (2012-2015, 2015-2018).
Fast and affordable test to detect contamination of drinking water has been developed by chemists from the Department of Analytical Chemistry, Regional Centre of Advanced Technologies and Materials, Palacký University in Olomouc. The tester, a small card, allows determination of chemical as well as microbiological pollution. Its users will be protected from serious health problems caused by contaminated water.
FTV Prima – Main News: link
On 12.7.2017 the R-lab laboratory obtained “A GMP Certificate for A Manufacturer” issued by the State Institute for Drug Control (SÚKL). The laboratory located in the building of the Regional Centre of Advanced Technologies and Materials (RCPTM), has been authorized to perform functions of a control laboratory in the range of chemical/physical quality control tests for human medicines and investigational medicinal products for human use in the field of manufacturing operations and the import of medicinal products.
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Scientific News In Nanotechnology in Analytical Chemistry
(Czech) Olomoučtí chemici pomáhají archeologům odhalit způsob života lidí v dávné historii >>
The Czech Science Foundation supports project “Characterization of nanoparticles by capillary electrophoresis” >>
Head of the Division:
About the group:
The group focuses on describing and modelling analytical processes during the transition to the nanoscale (the ionization of substances, nanoseparation beds, the influence of nanoparticles on the interaction of radiation and the analyte, electrochemical conversions) and characterizing nanomaterials using the methods of analytical chemistry (e.g. capillary electrophoresis). The group also works on the development of new analytical tools (ion sources, separation systems, sensitive detection systems) and advanced analytical methods (lower detection thresholds, accelerated analyses). Other favoured directions include the development of methods for observing the conversion of toxic and pharmacologically interesting substances, and the description of the interactions of these substances with living organisms. The group is also concerned with basic research on ionization and fragmentation in mass spectrometry, preconcentration, and chromatographic and electrophoretic separation. The knowledge obtained serves as a basis for e.g. analyzing foods or in forensic analysis.
V. Melenovsky, J. Petrak, T. Mracek, J. Benes, B.A. Borlaug, H. Nuskova, T. Pluhacek, J. Spatenka, J. Kovalcikova, Z. Drahota, J. Kautzner, J. Pirk, J. Houstek: Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. European Journal of Heart Failure, vol. 19, iss. 4, pp. 522-530, 2017.
T. Mašková, L. Hárendarčíková, J. Petr: Determination of Escherichia coli in urine using a low-cost foil-based microfluidic device. Talanta, vol. 170, pp. 36–40, 2017.
D. Baron, C. Cacho, J. Petr: Electrokinetic preconcentration of magnetite core – carboxylic shell nanoparticles by capillary electrophoresis. Journal of Chromatography A, vol. 1499, pp. 217–221, 2017.
L. Skultety, P. Frycak, Ch. Qiu, J. Smuts, L. Shear-Laude, K. Lemr, J.X. Mao, P. Kroll, K.A. Schug, A. Szewczak, C. Vaught, I. Lurie, V. Havlicek: Resolution of isomeric new designer stimulants using gas chromatography – Vacuum ultraviolet spectroscopy and theoretical Computations. Analytica Chimica Acta, vol. 971, pp. 55-67, 2017.
P. Janoš, J. Henych, J. Pfeifer, N. Zemanová, V. Pilařová, D. Milde, T. Opletal, J. Tolasz, M. Malýd, V. Štengl: Nanocrystalline cerium oxide prepared from a carbonate precursor and its ability to breakdown biologically relevant organophosphates. Environmental Science-Nano, vol. 4, iss. 6, pp. 1283–1293, 2017.
L. Borovcova, M. Hermanova, V. Pauk, M. Šimek, V. Havlíček, K. Lemr: Simple area determination of strongly overlapping ion mobility peaks. Analytica Chimica Acta, vol. 981, pp. 71-79, 2017.
V. Pauk, T. Pluháček, V. Havlíček, K.Lemr: Ultra-high performance supercritical fluid chromatography-mass spektrometry procedure for analysis of mono saccharides from plant gum binders. Analytica Chimica Acta, vol. 989, pp. 112-120, 2017.
L. Hárendarčíková, D. Baron, A. Šebestová, J. Rozsypal, J. Petr: True lab-in-a-syringe technology for bioassays. TALANTA, vol. 174, pp. 285-288, 2017.
L. Kučera, O. Kurka, P. Barták, P. Bednář: Liquid chromatography/high resolution tandem mass spectrometry – Tool for the study of polyphenol profile changes during micro-scale biogas digestion of grape marcs. CHEMOSPHERE, vol. 166, pp. 463-472, 2017.
D. Riman, K. Spyrou, A.E. Karantzalis, J. Hrbac, M.I. Prodromidis: Glucose sensing on graphite screen-printed electrode modified by sparking of copper nickel alloys. TALANTA, vol. 165, pp. 466-473, 2017.
J. Přichystal, K.A. Schug, K. Lemr, J. Novák, V. Havlíček: Structural Analysis of Natural Products. Anal. Chem., 88 (21), pp 10338–10346, 2016.
M. Švidrnoch, A. Přibylka, V. Bekárek, J. Ševčík, V. Smolka, V. Maier: Enantioseparation of d,l-2-hydroxyglutaric acid by capillaryelectrophoresis with tandem mass spektrometry-Fast and efficienttool for d- and l-2- hydroxyglutaracidurias diagnosis. Journal of Chromatography A, vol. 1467, pp. 383–390, 2016.
M. Jarošová, D. Walaszek, B. Wagner, D. Milde and E. Bulska: Influence of temperature on laser ablation fractionation during ICP-MS analysis for 213 nm and 266 nm laser wavelength micro-sampling. J. Anal. At. Spectrom., vol. 31, pp. 2089–2093, 2016.
P. Kučerová, J. Skopalová*, L. Kučera, J. Táborský, H. Švecová, K. Lemr, P. Cankař, P. Barták: Electrochemical oxidation of 5-hydroxymethyl tolterodine and identification of its oxidation products using liquid chromatography andmass spektrometry. Electrochimica Acta, vol. 215, pp. 617–625, 2016.
J. Znaleziona, D. Drahoňovský, B. Drahoš, J. Ševčík, V. Maier: Novel cationic coating agent for protein separation by capillary electrophoresis. J. Sep. Sci., vol. 39, iss. 12, pp. 2406–2412, 2016.
P. Ginterová, J. Znaleziona*, R. Knob, M. Douša, J. Petr, J. Ševčík: Enantiomeric purity control of R-cinacalcet in pharmaceutical product by capillary electrophoresis. Chemical Papers, vol. 70, iss. 8, pp. 1024–1030, 2016.
B. Papouskova, M. Bernard, J. Ottenschlager, J. Karban, P. Velisek, J. Hrbac, J. Sykora, J. Storch, J. Vacek: A comprehensive LC/MS analysis of novel cyclopentenedione library. Journal of Pharmaceutical and Biomedical Analysis, vol. 128, pp. 342–351, 2016.
O. Kurka, L. Kučera, P. Bednář: Analytical and semipreparative chiral separation of cis-itraconazole on cellulose stationary phases by high-performance liquid chromatography. J. Sep. Sci., vol. 39, iss. 14, pp. 2736–2745, 2016.
P. Fryčák*, L. Hartmanová, I. Lorencová, Karel Lemr: Screening of synthetic phosphodiesterase-5 inhibitors in herbal dietary supplements using transmission-mode desorption electrospray and high-resolution mass spektrometry. J. Mass Spectrom., vol. 51, iss. 5, pp. 358–362, 2016.
J. Znaleziona*, V. Maier: The use of PAMAM dendrimers as a dynamic coating for cyclodextrin mediated enantioseparation of selected basic drugs. Anal. Methods, vol. 8, iss.9, pp. 1968–1972, 2016.
L. Hartmanová, I. Lorencová, M. Volný, P. Fryčák, V. Havlíček, H. Chmelíčková, T. Ingr, K. Lemr: Lateral resolution of desorption nanoelectrospray: a nanospray tip without nebulizing gas as a source of primary charged droplets, Analyst vol. 141, Iss. 7, pp. 2150-2154, 2016.
T. Pluháček, K. Lemr, D. Ghosh, D. Milde, J. Novák, V. Havlíček: Characterization of microbial siderophores by mass spectrometry, MASS SPECTROMETRY REVIEWS vol. 35, Iss. 1, SI, pp. 35-47, 2016.
V. Pauk, V. Žihlová, L. Borovcová, V. Havlíček, K. Schug, K. Lemr: Fast separation of selected cathinones and phenylethylamines by supercritical ﬂuid chromatography, Journal of Chromatography A vol. 1423, pp. 169-176, 2015.
J. Znaleziona, P. Ginterova, J. Petr,P. Ondra, I. Valka, J. Sevcik, J. Chrastina, V. Maier: Determination and identification of synthetic cannabinoids and their metabolites in different matrices by modern analytical techniques, ANALYTICA CHIMICA ACTA vol. 874, pp. 11-25, 2015.
P. Kucerova, J. Skopalova, L. Kucera, J. Hrbac, K. Lemr: Electrochemical oxidation of fesoterodine and identification of its oxidation products using liquid chromatography and mass spektrometry, ELECTROCHIMICA ACTA vol. 159, pp. 131-139, 2015.
L. Veverková, Š. Hradilová, D. Milde, A. Panáček, J. Skopalová, L. Kvítek, K. Petrželová, R. Zbořil: Accurate determination of silver nanoparticles in animal tissues by inductively coupled plasma mass spectrometry, SPECTROCHIMICA ACTA PART B: ATOMIC SPECTROSCOPY vol. 102, pp. 7-11, 2014.
C. Cacho, Z. Markova, J. Sevcik, R. Zboril, J. Petr: Study of behavior of carboxylic magnetite core shell nanoparticles on a pH boundary. Journal of Chromatography A vol. 1364, pp. 59-63, 2014.
B. Papouskova, H. Fan, K. Lemr, K. A. Schug: Aspects of trapping efficiency and matrix effects in the development of a restricted-access-media-based trap-and-elute liquid chromatography with mass spectrometry method, JOURNAL OF SEPARATION SCIENCE vol. 37, iss. 16, pp. 2192-2199, 2014.
P. Ginterová, B. Sokolová, P. Ondra, J. Znaleziona, J. Petr, J. Ševčík, V. Maier: Determination of mushroom toxins ibotenic acid, muscimol and muscarine by capillary electrophoresis coupled with electrospray tandem mass spectrometry, TALANTA vol. 125, pp. 242-247, 2014.
M. Volny, J. Rolfs, B. Hakimi, P. Frycak, T. Schneider, D. Liu, G. Yen, D.T. Chiu, F. Turecek: Nanoliter Segmented-Flow Sampling Mass Spectrometry with Online Compartmentalization, Anal. Chem. vol. 86 (7), pp. 3647–3652, 2014.
R. Knob, J. Petr, J. Ševčík, V. Maier: Enantioseparation of tartaric acid by ligand-exchange capillary electrophoresis using contactless conductivity detection, JOURNAL OF SEPARATION SCIENCE, 2013.
V. Pauk, V. Havlíček, B. Papoušková, P. Sulovský, K. Lemr: Simultaneous identification of historical pigments Prussian blue and indigo in paintings by electrospray mass spectrometry, J. MASS SPECTROM. vol. 48, iss. 8, pp. 927-930, 2013.
L. Li, S. H. Yang, K. Lemr, V. Havlicek, K. A. Schug: Continuous flow-extractive desorption electrospray ionization: Analysis from “non-electrospray ionization-friendly” solvents and related mechanism, ANALYTICA CHIMICA ACTA vol. 769, pp. 84-90, 2013.
A. Pribylka, A.V. Almeida, M.O. Altmeyer, J. Petr, J. Sevcik, A. Manza, P. Neuzil: Fast spore breaking by superheating, Lab Chip vol. 13, pp. 1695-1698, 2013.
J. Součková, J. Skopalová, H. Švecová, P. Barták: Fused-Silica Capillary Dropping Mercury Electrode for Electrocapillary Measurements, ELECTROANALYSIS vol. 25, iss. 1, pp. 174-178, 2013.
V. Havlicek, K. Lemr, K. A. Schug: Current Trends in Microbial Diagnostics Based on Mass Spectrometry, ANAL. CHEM. vol. 85, iss. 2, pp. 790-797, 2013.
R. Knob, V. Maier, J. Petr, V. Ranc, J. Ševčík: On-line preconcentration of perfluorooctanoic acid and perfluorooctanesulfonic acid by nonaqueous capillary electrophoresis, ELECTROPHORESIS vol. 33, iss. 14, pp. 2159-2166, 2012.
P. Fryčák, J. Jirkovský, V. Ranc, P. Bednář, V. Havlíček, K. Lemr: Secondary processes in atmospheric pressure chemical ionization-ion trap mass spectrometry: a case study of orotic acid, J. MASS. SPECTROM. vol. 47, iss. 6, pp. 720-726, 2012.
V. Maier, V. Ranc, M. Švidrnoch, J. Petr, J. Ševčík, E. Tesařová, D. W. Armstrong: Study on the use of boromycin as a chiral selector in capillary electrophoresis, JOURNAL OF CHROMATOGRAPHY A vol. 1237, pp. 128-132, 2012.
K. Hron, M. Jelínková, P. Filzmoser, R. Kreuziger, P. Bednář, P. Barták: Statistical analysis of wines using a robust compositional biplot, TALANTA vol. 90, pp. 46-50, 2012.
J. Petr, V. Maier: Analysis of microorganisms by capillary electrophoresis, TRAC TRENDS IN ANALYTICAL CHEMISTRY vol. 31, pp. 9-22, 2012.
K. A. Schug, C. Serrano, P. Fryčák: Controlled band dispersion for quantitative binding determination and analysis with electrospray ionization-mass spectrometry, MASS SPECTROM. REV. vol. 29, iss. 5, pp. 806-829, 2010.
L. Hartmanova, V. Ranc, B. Papouskova, P. Bednar, V. Havlicek, K. Lemr: Fast profiling of anthocyanins in wine by desorption nano-electrospray ionization mass spectrometry, JOURNAL OF CHROMATOGRAPHY A vol. 1217, iss. 25, pp. 4223-4228, 2010.