Doc. RNDr. Jan Hošek, Ph.D.

Education and Qualification

2001 – 2006	Molecular biology and genetics, Phaculty of Science, Masaryk University Brno (Mgr.)
2008	Molecular biology and genetics, Phaculty of Science, Masaryk University Brno (RNDr.)
2006 – 2011	General and Molecular genetics, Phaculty of Science, Masaryk University Brno (Ph.D.)
2019	Proteomics and Genomics, Phaculty of Science, Masaryk University Brno (Assoc. Prof.)
2006-2011	Assistant, Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno
2011-2018	Research assistant, Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno
2011-2014	Junior Researcher, Regional Centre of Advanced Technologies and Materials, Olomouc
since 2019	Senior Researcher, Regional Centre of Advanced Technologies and Materials, Olomouc

Research activities

• Molecular pharmacology and pharmacognosy
• In vitro evaluation of biological activity (anti-inflammatory, cytostatic, cytotoxic) and mechanism of action of synthetic, natural, and semisynthetic compounds

 

Publication activity

• Number of publications (WoS): 61
• Number of citations (WoS): 804 (696 without self-citation)
• H-index: 16
• Book chapters: 2
  • Hošek J., Šmejkal K. Flavonoids as anti-inflammatory agents. In: Parnham M.J. (ed.) Compendium of Inflammatory Diseases. Birkhäuser Springer, Basel. ISBN: 978-3-7643-8530-9.
  • Šmejkal K., Neuwirth O., Treml J., Hošek J. 2016. Pro-oxidant Activity of Flavonoids and Their Possible Effects. In: Govil, J.N. and Pathak, M. (eds.) Recent Progress in Medicinal Plants Volume 40 – Flavonoids and Antioxidants. Studium Press LLC, USA. ISBN: 9781626990777
• Textbooks: 2
  • Bartoš M., Kolorz M., Hošek J., Bartošová L. Biotechnologie a farmakogenetika pro farmaceuty (Návody k praktickým cvičením). 2. vydání. Veterinární a farmaceutická univerzita Brno. 110 s. ISBN 978-80-7305-089-4.
  • Hošek J., Kolorz M., Lukáč K., Bartoš M. Biotechnology and pharmacogenetics for pharmacists (Manual for practical practices). 1. Vydání. Veterinární a farmaceutická univerzita Brno. 81 s. ISBN 978-80-7305-767-1.
• Patents:
  • 2 national patents (305624, 305585)
  • 3 national utility models (27030, 27032, 33273)

Internships

VII-IX 2007        Student internship in Protein Phosphorylation Unit at the University of Dundee, Scotland (3 months)

XI 2011             Research internship at the Department of Biology, American University of Beirut, Lebanon (1 month)

V-IX 2012          Research internship at the Department of Pharmaceutical and Pharmacologial Sciences, Università degli studi di Padova, Italy (4 months)

XI 2014             Visiting professor at the Pharmaceutical Faculty of the Kazakh National Medical ‎University (2 weeks)‎

 

Other activities

• Grants:
  • Ministry of Health of the Czech Republic (16-30571A; 16-27522A)
• Society Membership:
  • Czech-Slovak Biological Society

Selected publications

• Vančo J., Štarha P., Hošek J., Chalupová M., Suchý Jr. P., Trávníček Z.* Platinum(II)-oxalato complexes of seliciclib (CYC202) derivatives show different cellular effects and lesser adverse effects in mouse lymphoma model than cisplatin. J Biol Inorg Chem. 25: 67–73.
• Hošek J., Kos J., Strhárský T., Černá L., Štarha P., Vančo J., Trávníček Z., Devínsky F., Jampílek J. Investigation of Anti-Inflammatory Potential of N-Arylcinnamamide Derivatives. Molecules. 24: 4531.
• Massoud S.S., Louka F.R., Tusa A.F., Bordelon N.E., Fischer R.C., Mautner F.A., Vančo J., Hošek J., Dvořák Z., Trávníček Z.* Copper(II) complexes based on tripodal pyridyl amine derivatives as efficient anticancer agents. New J Chem. 43: 6186-6196.
• Massoud S. S., Ledet C. C., Junk T., Bosch S., Comba P., Herchel R., Hošek J., Trávníček Z., Fischer R. C., Mautner F. A. Dinuclear metal(ii)-acetato complexes based on bicompartmental 4-chlorophenolate: syntheses, structures, magnetic properties, DNA interactions and phosphodiester hydrolysis.Dalton Trans. 45: 12933-12950.
• Křikavová R., Hošek J., Suchý Jr P., Vančo J., Trávníček Z. Diverse in vitro and in vivo anti-inflammatory effects of trichlorido-gold (III) complexes with N6-benzyladenine derivatives. J. Inorg. Biochem. 134: 92-99.
• Hošek J., Vančo J., Štarha P., Paráková L., Trávníček Z. Effect of 2-Chloro-Substitution of Adenine Moiety in Mixed-Ligand Gold(I) Triphenylphosphine Complexes on Anti-Inflammatory Activity: The Discrepancy between the In Vivo and In Vitro Models. PLoS One. 8: e82441.
• Trávníček Z., Štarha P., Vančo J., Šilha T., Hošek J., Suchý Jr. P., Pražanová G. Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives. J. Med. Chem. 55: 4568-4579.