TOP RCPTM publikace 2019

(registered by Web of Science, ordered by IF)

P.Štarha, J.Vančo, Z.Trávníček: Platinum iodido complexes: A comprehensive overview of anticancer activity and mechanisms of action, COORDINATION CHEMISTRY REVIEWS vol. 380, pp. 103-135, 2019.
DOI: 10.1016/j.ccr.2018.09.017, IF = 14.499

Abstract: Platinum iodido complexes have long been recognized as synthetic intermediates of various platinum complexes (e.g., chlorido or carboxylato), including the world-wide used platinum-based anticancer drugs cisplatin, carboplatin and oxaliplatin. At the same time, platinum iodido complexes have been overlooked by bioinorganic chemists, because several pioneer works deemed the iodido ligand as unsuitable for the development of novel platinum-based metallotherapeutics. This was because most of platinum iodido complexes were identified as biologically and pharmacologically non-prospective as compared with the chlorido analogues. More recently, several research teams have developed various types of platinum iodido complexes as substances possessing the combination of promising chemical, physical, and especially biological properties. In particular, a number of platinum iodido complexes showed higher activity than their chlorido analogues and they exceeded even the activity of the conventional platinum-based drugs. Additionally, a lot of results have implied that relevant differences exist in the mechanism of action between platinum iodido agents, and their chlorido analogues and clinically-used platinum complexes