Nanomaterials in biomedicine

Head of the Division:

RNDr. Václav Ranc, Ph.D.

Václav Ranc received his Ph.D. degree in analytical chemistry in 2009 from the Department of Analytical chemistry, Palacky University in Olomouc, Czech Republic under a supervision of Prof. Karel Lemr. He was then employed at the Department of Analytical chemistry, Palacky University, Olomouc as an assistant professor from 2008 to 2010. In 2011, he joined the team of prof. Rainer at the department of medicine at the University of Fribourg in Switzerland as a research scientist. He worked there from 2011-2012.

He has been employed at the Regional center of advanced technologies and materials since 2012. He has authored or co-authored 38 scientific publications; H index = 9. He is a co-author of 2 international patents. His research activities are directed towards development of nano-sensors based on the utilization of Surface enhanced Raman spectroscopy and electrochemistry, and synthesis of functionalized nanomaterials.

About us

The research of the group Bio-Med is aimed on two overlapping fields: synthesis of novel nanomaterials and their consecutive application in biological and medicinal branches. Synthetic part of the group has a long time history in a design and synthesis of nanomaterials based on metals (iron, silver, gold, platinum) or their respective oxides. The resulting form of nanomaterials includes nanocomposites, nanoalloys as well as core-shell structures. Our infrastructure allows a characterization of nanomaterials using microscopic techniques as well as a study of interactions of selected nanomaterials with living systems on cellular level and on animals. Application part of the group specializes in a development of diverse analytical procedures applicable in medicinal diagnostics, environmental chemistry or toxicology or design of novel contrast agents applicable in MRI.

Research Areas:

  • Synthesis and modifications of nanomaterials

  • Development of sensors based on Raman spectroscopy and electrochemistry

  • Results highlights – Publications:

    A. Sitt, J. Soukupova, D. Miller, D. Verdi, R. Zboril, H. Hess, J. Lahann: Microscale Rockets and Picoliter Containers Engineered from Electrospun Polymeric Microtubes, SMALL, vol. 12, iss. 11, pp. 1432-1439, 2016.
    DOI: 10.1002/smll.201503467, IF = 8.368
    K. J. Datta, M. B. Gawande, K. K. R. Datta, V. Ranc, J. Pechousek, M. Krizek, J. Tucek, R. Kale, P. Pospisil, R. S. Varma, T. Asefa, G. Zoppellaro, R. Zboril: Micro–mesoporous iron oxides with record efficiency for the decomposition of hydrogen peroxide: morphology driven catalysis for the degradation of organic contaminants, J. MATER. CHEM. A vol. 4, iss. 2, pp. 596-604, 2016.
    DOI: 10.1039/c5ta08386a, IF = 7.443
    V. Urbanova, F. Karlicky, A. Matej, F. Sembera, Z. Janousek, J. A. Perman, V. Ranc, K. Cepe, J. Michl, M. Otyepka, R. Zboril: Fluorinated graphenes as advanced biosensors - Effect of fluorine coverage on electron transfer properties and adsorption of biomolecules, NANOSCALE, Advance Article, 2016.
    DOI: 10.1039/c6nr00353b, IF = 7.394
    M. Havrdova, K. Hola, J. Skopalik, K. Tomankova, M. Petr, K. Cepe, K. Polakova, J. Tucek, A. B. Bourlinos, R. Zboril: Toxicity of carbon dots – Effect of surface functionalization on the cell viability, reactive oxygen species generation and cell cycle, CARBON vol. 99, pp. 238-248, 2016.
    DOI: 10.1016/j.carbon.2015.12.027, IF = 6.196
    V. Urbanová, K. Holá, A. B. Bourlinos, K. Čépe, A. Ambrosi, A. H. Loo, M. Pumera, F. Karlický, M. Otyepka, R. Zbořil: Thiofluorographene-Hydrophilic Graphene Derivative with Semiconducting and Genosensing Properties, ADV. MATER., vol. 27, iss. 14, pp. 2305-2310, 2015.
    DOI: 10.1002/adma.201500094, IF = 15.409
    M. Magro, D. Baratella, P. Jakubec, G. Zoppellaro, J. Tucek, C. Aparicio, R. Venerando, G. Sartori, F. Francescato, F. Mion, N. Gabellini, R. Zboril, F. Vianello: Triggering Mechanism for DNA Electrical Conductivity: Reversible Electron Transfer between DNA and Iron Oxide Nanoparticles, ADVANCED FUNCTIONAL MATERIALS, vol. 25, iss. 12, pp. 1822-1831, 2015.
    DOI: 10.1002/adfm.201404372, IF = 10.4
    K. Hola, Y. Zhang, Y. Wang, E. P. Giannelis, R. Zboril and A. L. Rogach: "Carbon dots—Emerging light emitters for bioimaging, cancer therapy and optoelectronics", NANO TODAY, 2014.
    DOI: 10.1016/j.nantod.2014.09.004, IF = 18.432
    V. Urbanova, M. Magro, A. Gedanken, D. Baratella, F. Vianello and R. Zboril: "Nanocrystalline Iron Oxides, Composites, and Related Materials as a Platform for Electrochemical, Magnetic, and Chemical Biosensors", CHEM. MATER., vol. 26, iss. 23, pp. 6653-6673, 2014.
    DOI: 10.1021/cm500364x, IF = 8.535
    A. Panacek, R. Prucek, J. Hrbac, T. Nevecna, J. Steffkova, R. Zboril and L. Kvitek: "Polyacrylate-Assisted Size Control of Silver Nanoparticles and Their Catalytic Activity", CHEM. MATER., vol. 26, iss. 3, pp. 1332-1339, 2014.
    DOI: 10.1021/cm400635z, IF = 8.535
    K. Hola, A. Bourlinos, O. Kozak, K. Berka, K. Siskova, M. Havrdova, J. Tucek, K. Safarova, M. Otyepka, E. Giannelis and R. Zboril: "Photoluminescence effects of graphitic core size and surface functional groups in carbon dots: COO− induced red-shift emission", CARBON, vol. 70, pp. 279-286, 2014.
    DOI: 10.1016/j.carbon.2014.01.008, IF = 6.160
    V. Ranc, Z. Markova, M. Hajduch, R. Prucek, L. Kvitek, J. Kaslik, K. Safarova and R. Zboril: " Magnetically Assisted Surface-Enhanced Raman Scattering Selective Determination of Dopamine in an Artificial Cerebrospinal Fluid and a Mouse Striatum Using Fe 3 O 4 /Ag Nanocomposite ", ANAL. CHEM., vol. 86, iss. 6, pp. 2939-2946, 2014.
    DOI: 10.1021/ac500394g, IF = 5.825

    Key Collaborators

    Asst. Prof. Martin Pumera

    • He received his PhD at Charles University, Czech Republic, in 2001.
    • Currently works at Nanyang Assistant Professor at School of Physical and Mathematical Sciences, CBC, NTU.

    Research areas:

    • lab on chip devices
    • nanomaterial-based electrochemical biosensors

    Prof. Fabio Vianello

    • He received his PhD at the University of Padova, in 1993
    • Currently works as Associate Professor of biophysics and biochemistry at the Department of Comparative Biomedicine and Food Science

    Research interests:

    • purification and the characterization of kinases and amine oxidases and in the biotechnological application of purified enzymes in the development of amperometric and potentiometric biosensors.
    • application of fluoride ion as nuclear probe in nuclear magnetic resonance in living systems and the generation and decay of free radicals both in vitro and in vivo.
    • electron transfer phenomena of low molecular weight metal complexes in biological systems.
    • application of nuclear magnetic spectroscopy to the evaluation of the viability of explanted organs and to the interaction between antioxidant molecules and free radicals in foods.
    • nanobiotechnology research and in the development of nanobiosensors and in the application of magnetic nanoparticles.

    Dr. Clemens Diwoky

    • He received his PhD at the Graz University of Technology in 2014
    • Currently works as staff Scientist at Institute of Molecular Biosciences, University of Graz

    Research interests:

    • Biomedical Engineering
    • Signal Processing
    • MRI
    • RF Engineering
    • Electrical Engineering

    Dr. Aristides Bakandritsos

    • He received his PhD at the Chemistry Department of the National and Kapodistrian University of Athens in 2006
    • Currently works at University of Patras, Rio, Greece

    Research interests

    • Bottom up synthesis of hybrid (organic/inorganic) nanocolloids through self-assembly and "grafting-to" techniques.
    • Physicochemical functionalization of their surface with small molecules, biopolymers and synthetic macromolecules of various architecture.
    • Study of magnetic and colloidal properties and interactions with molecules of biological interestStudy of structure-property relationships and optimization towards their applications as therapeutic nanoplatforms
    • Self-assembled swellable phyllomorphic materials and their composites with organic (porous carbons, carbon nanotubes) or inorganic materials (nanoparti-culate metals and metal oxides).

    Dr. Stefan Vajda

    • He received his PhD at Charles University Prague in 1990.
    • Currently works at Argonne National Laboratory, Chemistry Division, Argonne, Illinois, USA

    Research interests

    • Physical and chemical properties of supported size-selected metal clusters and cluster-based nanomaterials
    • Synchrotron X-ray studies of the thermal stability and kinetics of nanoparticle growth
    • Surface composition and morphology effects on nanoparticle properties
    • Controlled assembly; Optical properties; Nanocatalysis.

    Senior researchers

    Doc. RNDr. Libor Kvítek, PhD.

    • Associate professor

    Research interests

    • heterogeneous systems – surface energy and wettability of solid surfaces, viscosity and surface tension of liquids and solutions
    • study of solutions of surface-active compounds and their micelles
    • electrochemistry of homogenenous and heterogeneous systems;
    • study of preparation, properties and application potential of nanoparticles of silver and other, especially noble metals.

    Selected publications

    CHEMISTRY OF MATERIALS (2014) 26, 3 1332-1339, MATERIALS CHEMISTRY AND PHYSICS (2013), 140, 2-3, JOURNAL OF PHYSICAL CHEMISTRY C (2008), 112, 15, 5825-5834.

    Doc. RNDr. Aleš Panáček, Ph.D.

    • Associate professor

    Research interests

    • Colloid silver: preparation, modification, study of stability, biological activity, and electric and optical properties
    • Transmission electron microscopy

    Selected Publications

    CHEMISTRY OF MATERIALS (2014) 26, 3, 1332-1339, COLLOIDS AND SURFACES B-BIOINTERFACES (2013), 110, 191-198, BIOMATERIALS (2009), 30, 31, 6333-6340.

    Ing. Veronika Urbanová, Ph.D.

    • Professor assistant

    Research interests

    • Development of electrochemical sensors
    • Characterization of carbon nanomaterial using electrochemistry

    Selected publications

    ADV. MATER., (2015) 27, 14, 2305-2310, CHEM. MATER. (2014), 26, 23, 6653-6673, ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2013), 405, 11, 3899-3906.

    Junior researchers

    Mgr. Marková Zdenka

    Mgr. Jakubec Petr, Ph.D.

    Mgr. Havrdová Markéta

    Mgr. Holá Kateřina

    Mgr. Balzerová Anna

    Mgr. Chaloupková Zuzana

    Mgr. Fargašová Ariana

    Mgr. Hradilová Šárka, Ph.D.

    Mgr. Karlíková Martina

    RNDr. Soukupová Jana, Ph.D.

    Ing. Mgr. Vyhnálková Renáta, PhD.

    Mgr. Poláková Kateřina, Ph.D.

    Froning Jens Peter, MS.c.

    Mgr. Adámková Šárka