The research of the group Bio-Med is aimed on two overlapping fields: synthesis of novel nanomaterials and their consecutive application in biological and medicinal branches. Synthetic part of the group has a long time history in a design and synthesis of nanomaterials based on metals (iron, silver, gold, platinum) or their respective oxides. The resulting form of nanomaterials includes nanocomposites, nanoalloys as well as core-shell structures. Our infrastructure allows a characterization of nanomaterials using microscopic techniques as well as a study of interactions of selected nanomaterials with living systems on cellular level and on animals. Application part of the group specializes in a development of diverse analytical procedures applicable in medicinal diagnostics, environmental chemistry or toxicology or design of novel contrast agents applicable in MRI.
Synthesis and modifications of nanomaterials
The synthetic group sub-division is focused on a development of procedures applicable in a synthesis of various nanomaterials with interesting properties applicable in biological systems.
Fundamental research in the field of chemical synthesis can be divided into several classes:
- Metal nanoparticles
- Magnetic iron oxides
- Carbon – based nanomaterials
- Polymer-based micelles
The group possesses an infrastructure capable to perform targeted studies of the behavior of prepared nanomaterial in particular applications. Metal nanoparticles are further studied as potential nanocatalysts or antimicrobial agents. Magnetic iron oxides are studied as vesicles for a targeted drug delivery and contrast agents in MRI, nanocomposites are studied as substrates for Raman spectroscopy and electrochemical sensing. We understand that utilization of as-prepared nanomaterials in biological systems requires complex study of their respective toxicity. This important task is being performed by a particular group sub-division, where interactions of prepared nanomaterials with biological systems on a cellular and molecular levels are complexly studied. This includes MTT testing, analysis using Raman spectroscopy and atomic force microscopy, and analysis of ROS. Utilization of AFM and Raman spectroscopy is usually performed in liquid phase to model conditions closer to ones find in targeted biological systems.
Development of sensors based on Raman spectroscopy and electrochemistry
Analytical group sub-division is focused on a development of analytical platforms for analysis of numerous physiologically active compounds, where many of them can be potentially studied as biomarkers.
This includes for example dopamine, DNA, human IgG and others. The development of analytical procedures is being performed:
- Using electrochemistry, where magnetic iron oxides, nanocomposites or carbon-based nanomaterials are utilized as active substrates.
- Using surface enhanced Raman spectroscopy, where metal nanoparticles or noble metal containing magnetic nanocomposites are used.
The group also specializes on a complex functionalization of respective nanomaterials to enhance their analytical responses in particular applications. This includes anchoring of antibodies, selective enzymes, low-molecular selectors, nucleic acids or oligonucleotides.
Results highlights – Publications:
DOI: 10.1002/smll.201503467, IF = 8.368
DOI: 10.1039/c5ta08386a, IF = 7.443
DOI: 10.1039/c6nr00353b, IF = 7.394
DOI: 10.1016/j.carbon.2015.12.027, IF = 6.196
DOI: 10.1002/adma.201500094, IF = 15.409
DOI: 10.1002/adfm.201404372, IF = 10.4
DOI: 10.1016/j.nantod.2014.09.004, IF = 18.432
DOI: 10.1021/cm500364x, IF = 8.535
DOI: 10.1021/cm400635z, IF = 8.535
DOI: 10.1016/j.carbon.2014.01.008, IF = 6.160
DOI: 10.1021/ac500394g, IF = 5.825
Asst. Prof. Martin Pumera
- He received his PhD at Charles University, Czech Republic, in 2001.
- Currently works at Nanyang Assistant Professor at School of Physical and Mathematical Sciences, CBC, NTU.
- lab on chip devices
- nanomaterial-based electrochemical biosensors
Prof. Fabio Vianello
- He received his PhD at the University of Padova, in 1993
- Currently works as Associate Professor of biophysics and biochemistry at the Department of Comparative Biomedicine and Food Science
- purification and the characterization of kinases and amine oxidases and in the biotechnological application of purified enzymes in the development of amperometric and potentiometric biosensors.
- application of fluoride ion as nuclear probe in nuclear magnetic resonance in living systems and the generation and decay of free radicals both in vitro and in vivo.
- electron transfer phenomena of low molecular weight metal complexes in biological systems.
- application of nuclear magnetic spectroscopy to the evaluation of the viability of explanted organs and to the interaction between antioxidant molecules and free radicals in foods.
- nanobiotechnology research and in the development of nanobiosensors and in the application of magnetic nanoparticles.
Dr. Clemens Diwoky
- He received his PhD at the Graz University of Technology in 2014
- Currently works as staff Scientist at Institute of Molecular Biosciences, University of Graz
- Biomedical Engineering
- Signal Processing
- RF Engineering
- Electrical Engineering
Dr. Aristides Bakandritsos
- He received his PhD at the Chemistry Department of the National and Kapodistrian University of Athens in 2006
- Currently works at University of Patras, Rio, Greece
- Bottom up synthesis of hybrid (organic/inorganic) nanocolloids through self-assembly and "grafting-to" techniques.
- Physicochemical functionalization of their surface with small molecules, biopolymers and synthetic macromolecules of various architecture.
- Study of magnetic and colloidal properties and interactions with molecules of biological interestStudy of structure-property relationships and optimization towards their applications as therapeutic nanoplatforms
- Self-assembled swellable phyllomorphic materials and their composites with organic (porous carbons, carbon nanotubes) or inorganic materials (nanoparti-culate metals and metal oxides).
Dr. Stefan Vajda
- He received his PhD at Charles University Prague in 1990.
- Currently works at Argonne National Laboratory, Chemistry Division, Argonne, Illinois, USA
- Physical and chemical properties of supported size-selected metal clusters and cluster-based nanomaterials
- Synchrotron X-ray studies of the thermal stability and kinetics of nanoparticle growth
- Surface composition and morphology effects on nanoparticle properties
- Controlled assembly; Optical properties; Nanocatalysis.
Doc. RNDr. Libor Kvítek, PhD.
- Associate professor
- heterogeneous systems – surface energy and wettability of solid surfaces, viscosity and surface tension of liquids and solutions
- study of solutions of surface-active compounds and their micelles
- electrochemistry of homogenenous and heterogeneous systems;
- study of preparation, properties and application potential of nanoparticles of silver and other, especially noble metals.
CHEMISTRY OF MATERIALS (2014) 26, 3 1332-1339, MATERIALS CHEMISTRY AND PHYSICS (2013), 140, 2-3, JOURNAL OF PHYSICAL CHEMISTRY C (2008), 112, 15, 5825-5834.
Doc. RNDr. Aleš Panáček, Ph.D.
- Associate professor
- Colloid silver: preparation, modification, study of stability, biological activity, and electric and optical properties
- Transmission electron microscopy
CHEMISTRY OF MATERIALS (2014) 26, 3, 1332-1339, COLLOIDS AND SURFACES B-BIOINTERFACES (2013), 110, 191-198, BIOMATERIALS (2009), 30, 31, 6333-6340.
Ing. Veronika Urbanová, Ph.D.
- Professor assistant
- Development of electrochemical sensors
- Characterization of carbon nanomaterial using electrochemistry
ADV. MATER., (2015) 27, 14, 2305-2310, CHEM. MATER. (2014), 26, 23, 6653-6673, ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2013), 405, 11, 3899-3906.
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