Publication in Inorganic Chemistry
The publication entitled “Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes” (authors: P. Štarha, A. Habtemariam, I. Romero-Canelón, G. J. Clarkson, P. J. Sadler) was reported, in cooperation with Prof. Sadler´s research group form University of Warwick (Coventry, U.K.), in Inorganic Chemistry journal. The publication reports preparation and characterization (including a single-crystal X-ray analysis) of novel half-sandwich hydrosulfido organo-iridium(III) complexes of a typical piano-stool geometry. In vitro cytotoxicity studies on the A2780 human ovarian cancer cells showed two representatives containing a Cpbiph cyclopentadienyl ligand as more potent than cisplatin. Mechanism of action of these Cpbiph complexes is most likely redox-linked, as proved by the oxidation of reduced glutathione (GSH) to glutathione disulfide (GSSG) in the presence of the studied Cpbiph complexes.